SEPTIN12 - septin 12 Gene

Homo sapiens (human)

Also known as SEPT12; SPGF10

Gene ID: 124404 | Gene type: protein coding

About SEPTIN12

Summary

This gene encodes a guanine-nucleotide binding protein and member of the septin family of cytoskeletal GTPases. Septins play important roles in cytokinesis, exocytosis, embryonic development, and membrane dynamics. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

SEPTIN12 Products(1)

mRNA	Protein	Name
XM_054379608.1	XP_054235583.1	septin-12 isoform X3

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GTP binding	IDA IDA: Inferred from direct assay	18443421	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	25588830	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18047794	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	18443421	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in midbody	IDA IDA: Inferred from direct assay	18047794	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	18047794	GOA
part of septin complex	IDA IDA: Inferred from direct assay	25588830	GOA
located in sperm annulus	IDA IDA: Inferred from direct assay	22275165	GOA
located in spindle	IDA IDA: Inferred from direct assay	18047794	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

septin-12

testicular tissue protein Li 168

SEPTIN12 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SEPTIN12	Q8IYM1	SEPTIN4	Homo sapiens	O43236	Anti Tag CoIP	33961781
Intra	SEPTIN12	Q8IYM1	SEPTIN4	Homo sapiens	O43236	Y2H	25775403
Intra	SEPTIN12	Q8IYM1	SEPTIN4	Homo sapiens	O43236	IF	25588830
Intra	SEPTIN12	Q8IYM1	SEPTIN4	Homo sapiens	O43236	Anti Tag CoIP	25588830
Intra	SEPTIN12	Q8IYM1	SPAG4	Homo sapiens	Q9NPE6	Imaging	25775403
Intra	SEPTIN12	Q8IYM1	SPAG4	Homo sapiens	Q9NPE6	Anti Tag CoIP	25775403
Intra	SEPTIN12	Q8IYM1	SPAG4	Homo sapiens	Q9NPE6	IF	25775403
Intra	SEPTIN12	Q8IYM1	SPAG4	Homo sapiens	Q9NPE6	Y2H	25775403
Intra	SEPTIN12	Q8IYM1	SEPTIN7	Homo sapiens	Q16181	Anti Tag CoIP	25588830
Intra	SEPTIN12	Q8IYM1	SEPTIN7	Homo sapiens	Q16181	IF	25588830
Intra	SEPTIN12	Q8IYM1	SEPTIN7	Homo sapiens	Q16181	Anti Tag CoIP	33961781
Intra	SEPTIN12	Q8IYM1	SEPTIN6	Homo sapiens	Q14141	Anti Tag CoIP	33961781
Intra	SEPTIN12	Q8IYM1	SEPTIN6	Homo sapiens	Q14141	Anti Tag CoIP	25588830
Intra	SEPTIN12	Q8IYM1	SEPTIN6	Homo sapiens	Q14141	Y2H	25775403
Intra	SEPTIN12	Q8IYM1	SEPTIN6	Homo sapiens	Q14141	IF	25588830
Intra	SEPTIN12	Q8IYM1	SEPTIN5	Homo sapiens	Q99719	Anti Tag CoIP	33961781
Intra	SEPTIN12	Q8IYM1	SEPTIN5	Homo sapiens	Q99719	Validated Y2H	32296183
Intra	SEPTIN12	Q8IYM1	SEPTIN1	Homo sapiens	Q8WYJ6	Validated Y2H	25416956
Intra	SEPTIN12	Q8IYM1	SEPTIN1	Homo sapiens	Q8WYJ6	Y2H Prey Pooling	25416956
Intra	SEPTIN12	Q8IYM1	SEPTIN1	Homo sapiens	Q8WYJ6	Validated Y2H	32296183
Intra	SEPTIN12	Q8IYM1	SEPTIN1	Homo sapiens	Q8WYJ6	Anti Tag CoIP	31515488
Intra	SEPTIN12	Q8IYM1	SEPTIN2	Homo sapiens	Q15019	Anti Tag CoIP	25588830
Intra	SEPTIN12	Q8IYM1	SEPTIN2	Homo sapiens	Q15019	IF	25588830
Intra	SEPTIN12	Q8IYM1	SEPTIN2	Homo sapiens	Q15019	Anti Tag CoIP	33961781
Intra	SEPTIN12	Q8IYM1	RSPH14	Homo sapiens	Q9UHP6	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12681	SEPTIN1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS12682	SEPTIN2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

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