SPAG4 - sperm associated antigen 4 Gene

Homo sapiens

Also known as SUN4; CT127

Gene ID: 6676 | Gene type: protein coding

About SPAG4

Cytogenetic location: 20q11.22 Genomic coordinates (GRCh38): 20:35,615,829-35,621,094 (from NCBI)

This gene has 8 transcripts (splice variants), 107 orthologues and 4 paralogues. Broad expression in testis (RPKM 8.6), pancreas (RPKM 6.3) and 20 other tissues.

Summary

The mammalian sperm flagellum contains two cytoskeletal structures associated with the axoneme: the outer dense fibers surrounding the axoneme in the midpiece and principal piece and the fibrous sheath surrounding the outer dense fibers in the principal piece of the tail. Defects in these structures are associated with abnormal tail morphology, reduced sperm motility, and infertility. In the rat, the protein encoded by this gene associates with an outer dense fiber protein via a leucine zipper motif and localizes to the microtubules of the manchette and axoneme during sperm tail development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

SPAG4 Products(2)

mRNA	Protein	Name
NM_001317931.1	NP_001304860.1	sperm-associated antigen 4 protein isoform 2
NM_003116.3	NP_003107.1	sperm-associated antigen 4 protein isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25775403	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SPAG4 Protein Structure

Sad1_UNC

0
100
200
300
400
437 a.a.

Protein Preferred Names

Protein Names

sperm-associated antigen 4 protein

SUN domain-containing protein 4

Related Diseases

Diseases

Alias

Spermatogenic Failure 9

Male Infertility Due To Globozoospermia	SPGF9
Male Infertility Due To Round-Headed Spermatozoa	Globozoospermia, Complete
Globozoospermia, Total	Globozoospermia
Globozoospermia Syndrome	Round-Headed Sperm Syndrome
Globozoospermia Complete	Globozoospermia Total

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13623	SPAG4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SPAG4	VGNC	VGNC:77850
Rattus norvegicus	SPAG4	RGD	RGD:620151
Felis catus	SPAG4	VGNC	VGNC:65596
Mus musculus	SPAG4	MGD	MGI:2444120
Canis familiaris	SPAG4	VGNC	VGNC:54733
Bos taurus	SPAG4	VGNC	VGNC:35166

Name
Email *

	Sorry, but the email address you supplied was invalid.