Cd24a - CD24a antigen Gene

Mus musculus

Also known as HSA; Cd24; Ly-52; nectadrin

Gene ID: 12484 | Gene type: protein coding

About Cd24a

Summary

Enables HSP70 protein binding activity; HSP90 protein binding activity; and carbohydrate binding activity. Involved in several processes, including Chemokine Receptor transport out of membrane raft; negative regulation of cytokine production; and regulation of inflammatory response to wounding. Acts upstream of or within several processes, including positive regulation of immune response; regulation of cell-cell adhesion; and regulation of lymphocyte activation. Located in cell projection membrane; external side of plasma membrane; and membrane raft. Is anchored component of external side of plasma membrane. Is expressed in several structures, including extraembryonic component; genitourinary system; hemolymphoid system; hindlimb; and retina. Human ortholog(s) of this gene implicated in multiple sclerosis. Orthologous to human CD24 (CD24 molecule). [provided by Alliance of Genome Resources, Apr 2022]

Cd24a Products(1)

mRNA	Protein	Name
NM_009846.2	NP_033976.1	signal transducer CD24 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables Hsp70 protein binding	IDA IDA: Inferred from direct assay	19264983	MGI
enables Hsp90 protein binding	IDA IDA: Inferred from direct assay	19264983	MGI
enables carbohydrate binding	IDA IDA: Inferred from direct assay	15633604	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	7524641	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of B cell apoptotic process	IDA IDA: Inferred from direct assay	8920854	MGI
acts upstream of B cell proliferation	IDA IDA: Inferred from direct assay	8920854	MGI
acts upstream of CD4-positive, alpha-beta T cell proliferation	IDA IDA: Inferred from direct assay	8125140	MGI
acts upstream of CD4-positive, alpha-beta T cell proliferation	IMP IMP: Inferred from mutant phenotype	15314074	MGI
acts upstream of T cell homeostatic proliferation	IMP IMP: Inferred from mutant phenotype	15477346	MGI
acts upstream of or within apoptotic mitochondrial changes	IDA IDA: Inferred from direct assay	14707049	MGI
acts upstream of or within apoptotic nuclear changes	IDA IDA: Inferred from direct assay	14707049	MGI
acts upstream of or within apoptotic signaling pathway	IDA IDA: Inferred from direct assay	8920854	MGI
acts upstream of calcium-mediated signaling	IDA IDA: Inferred from direct assay	7613634	MGI
involved in cell migration	IMP IMP: Inferred from mutant phenotype	16390867	MGI
acts upstream of or within cell surface receptor signaling pathway	IDA IDA: Inferred from direct assay	7613634	MGI
involved in chemokine receptor transport out of membrane raft	IMP IMP: Inferred from mutant phenotype	16390867	MGI
involved in cholesterol homeostasis	IMP IMP: Inferred from mutant phenotype	16390867	MGI
acts upstream of or within heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IDA IDA: Inferred from direct assay	8145052	MGI
acts upstream of or within homotypic cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	7613634	MGI
acts upstream of integrin activation	IDA IDA: Inferred from direct assay	10601245	MGI
acts upstream of integrin activation	IMP IMP: Inferred from mutant phenotype	10601245	MGI
acts upstream of or within leukocyte cell-cell adhesion	IDA IDA: Inferred from direct assay	7534304	MGI
acts upstream of or within leukocyte migration involved in inflammatory response	IMP IMP: Inferred from mutant phenotype	15314074	MGI
acts upstream of or within negative regulation of B cell proliferation	IDA IDA: Inferred from direct assay	8920854	MGI
acts upstream of or within negative regulation of T cell homeostatic proliferation	IMP IMP: Inferred from mutant phenotype	16769998	MGI
acts upstream of or within negative regulation of erythrocyte aggregation	IMP IMP: Inferred from mutant phenotype	9028339	MGI
acts upstream of or within negative regulation of erythrocyte clearance	IMP IMP: Inferred from mutant phenotype	9028339	MGI
involved in negative regulation of inflammatory response to wounding	IPI IPI: Inferred from physical interaction	19264983	MGI
involved in negative regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	19264983	MGI
involved in negative regulation of monocyte chemotactic protein-1 production	IMP IMP: Inferred from mutant phenotype	19264983	MGI
acts upstream of or within negative regulation of neuroblast proliferation	IMP IMP: Inferred from mutant phenotype	11978835	MGI
acts upstream of or within negative regulation of neurogenesis	IMP IMP: Inferred from mutant phenotype	15737737	MGI
acts upstream of or within negative regulation of neuron differentiation	IMP IMP: Inferred from mutant phenotype	15737737	MGI
involved in negative regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	19264983	MGI
acts upstream of neuroblast proliferation	IMP IMP: Inferred from mutant phenotype	11978835	MGI
acts upstream of or within neuromuscular synaptic transmission	IGI IGI: Inferred from genetic interaction	16606832	MGI
acts upstream of or within neuromuscular synaptic transmission	IMP IMP: Inferred from mutant phenotype	16606832	MGI
acts upstream of neuron projection development	IDA IDA: Inferred from direct assay	19458237	MGI
acts upstream of or within neuron projection development	IDA IDA: Inferred from direct assay	11283023	MGI
acts upstream of neuron projection development	IGI IGI: Inferred from genetic interaction	19458237	MGI
acts upstream of or within neuron projection development	IMP IMP: Inferred from mutant phenotype	11283023	MGI
acts upstream of peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	9177270	MGI
acts upstream of or within positive regulation of B cell apoptotic process	IDA IDA: Inferred from direct assay	8920854	MGI
acts upstream of or within positive regulation of CD4-positive, alpha-beta T cell proliferation	IDA IDA: Inferred from direct assay	8125140	MGI
acts upstream of or within positive regulation of CD4-positive, alpha-beta T cell proliferation	IMP IMP: Inferred from mutant phenotype	15314074	MGI
acts upstream of or within positive regulation of T cell homeostatic proliferation	IMP IMP: Inferred from mutant phenotype	15477346	MGI
acts upstream of or within positive regulation of T cell mediated immune response to tumor cell	IDA IDA: Inferred from direct assay	7774619	MGI
acts upstream of or within positive regulation of alpha-beta T cell proliferation	IDA IDA: Inferred from direct assay	1346270	MGI
acts upstream of or within positive regulation of alpha-beta T cell proliferation	IMP IMP: Inferred from mutant phenotype	1385153	MGI
acts upstream of or within positive regulation of calcium-mediated signaling	IDA IDA: Inferred from direct assay	7613634	MGI
acts upstream of or within positive regulation of cell adhesion mediated by integrin	IDA IDA: Inferred from direct assay	10601245	MGI
acts upstream of or within positive regulation of cell adhesion mediated by integrin	IMP IMP: Inferred from mutant phenotype	10601245	MGI
acts upstream of or within positive regulation of cell-cell adhesion	IDA IDA: Inferred from direct assay	7669058	MGI
acts upstream of or within positive regulation of cell-cell adhesion mediated by integrin	IDA IDA: Inferred from direct assay	7534304	MGI
acts upstream of or within positive regulation of inflammatory response to antigenic stimulus	IMP IMP: Inferred from mutant phenotype	10791997	MGI
involved in positive regulation of inflammatory response to wounding	IMP IMP: Inferred from mutant phenotype	19264983	MGI
acts upstream of or within positive regulation of integrin activation	IDA IDA: Inferred from direct assay	7534304	MGI
acts upstream of or within positive regulation of integrin activation	IMP IMP: Inferred from mutant phenotype	10601245	MGI
acts upstream of or within positive regulation of neuron projection development	IDA IDA: Inferred from direct assay	19458237	MGI
acts upstream of or within positive regulation of neuron projection development	IGI IGI: Inferred from genetic interaction	19458237	MGI
acts upstream of or within positive regulation of peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	9177270	MGI
acts upstream of or within pre-B cell differentiation	IMP IMP: Inferred from mutant phenotype	7795661	MGI
acts upstream of or within regulation of B cell differentiation	IMP IMP: Inferred from mutant phenotype	7795661	MGI
acts upstream of or within regulation of cell-cell adhesion	IDA IDA: Inferred from direct assay	8117278	MGI
acts upstream of or within regulation of cell-cell adhesion mediated by integrin	IDA IDA: Inferred from direct assay	8145052	MGI
involved in regulation of cytokine-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	16390867	MGI
involved in response to molecule of bacterial origin	IDA IDA: Inferred from direct assay	15493995	MGI
acts upstream of or within synaptic vesicle endocytosis	IMP IMP: Inferred from mutant phenotype	16606832	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	9324354	MGI
located in ciliary membrane	IDA IDA: Inferred from direct assay	11978835	MGI
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	1346270	MGI
located in membrane	IDA IDA: Inferred from direct assay	11283023	MGI
located in membrane raft	IDA IDA: Inferred from direct assay	15493995	MGI
located in microvillus membrane	IDA IDA: Inferred from direct assay	11978835	MGI
located in motile cilium	IDA IDA: Inferred from direct assay	35087169	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	11978835	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

signal transducer CD24

M1/69-J11D heat stable antigen	R13-Ag
X62 heat stable antigen	cluster of differentiation 24
heat stable antigen	lymphocyte antigen 52

Recombinant Cd24a Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72747	CD24 Protein, Mouse (HEK293, hFc)	P24807 (N27-G53)	≥95%
HY-P78255	CD24 Protein, Mouse (27a.a, HEK293, mFc)	P24807 (N27-G53)	≥95%

Orthologs Information

Species	Symbol	Source	ID
Macaca fascicularis	Cd24a	NCBI
Rattus norvegicus	Cd24a	NCBI

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