GGT6 - gamma-glutamyltransferase 6 Gene

Homo sapiens

Gene ID: 124975 | Gene type: protein coding

About GGT6

Cytogenetic location: 17p13.2 Genomic coordinates (GRCh38): 17:4,556,140-4,560,577 (from NCBI)

This gene has 6 transcripts (splice variants), 122 orthologues and 6 paralogues. Biased expression in colon (RPKM 26.8), kidney (RPKM 22.6) and 12 other tissues.

Summary

GGT6 belongs to the gamma-glutamyltransferase (GGT; EC 2.3.2.2) gene family. GGT is a membrane-bound extracellular Enzyme that cleaves gamma-glutamyl peptide bonds in glutathione and other Peptides and transfers the gamma-glutamyl moiety to acceptors. GGT is also key to glutathione homeostasis because it provides substrates for glutathione synthesis (Heisterkamp et al., 2008 [PubMed 18357469]).[supplied by OMIM, Oct 2008]

GGT6 Products(5)

mRNA	Protein	Name
NM_001122890.3	NP_001116362.1	glutathione hydrolase 6 isoform a
NM_001288702.2	NP_001275631.1	glutathione hydrolase 6 isoform c
NM_001288703.2	NP_001275632.1	glutathione hydrolase 6 isoform d
NM_001288704.2	NP_001275633.1	glutathione hydrolase 6 isoform e
NM_153338.4	NP_699169.2	glutathione hydrolase 6 isoform b

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GGT6 Protein Structure

G_glu_transpept

0
100
200
300
400
493 a.a.

Protein Preferred Names

Protein Names

glutathione hydrolase 6

gamma-glutamyltransferase 6 homolog

GGT6 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	GGT6	Q6P531	TNMD	Homo sapiens	Q9H2S6-2	Validated Y2H	32296183
Intra	GGT6	Q6P531	TMBIM1	Homo sapiens	Q969X1	Validated Y2H	32296183
Intra	GGT6	Q6P531	GRINA	Homo sapiens	Q7Z429	Validated Y2H	32296183
Intra	GGT6	Q6P531	FAM3C	Homo sapiens	Q92520	Validated Y2H	32296183
Intra	GGT6	Q6P531	SEC22A	Homo sapiens	Q96IW7	Validated Y2H	32296183
Intra	GGT6	Q6P531	FAIM2	Homo sapiens	Q9BWQ8	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Glutathionuria

Gamma-Glutamyltransferase Deficiency	Ggt Deficiency
Gtg Deficiency	Gamma-Glutamyltranspeptidase Deficiency
Glutathioninuria	Gamma-Glutamyl Transpeptidase Deficiency
Gamma-Glutamyl Transferase Deficiency	Ggt1 Deficiency
GLUTH

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05405	GGT6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	GGT6	VGNC	VGNC:29345
Felis catus	GGT6	VGNC	VGNC:99063
Macaca mulatta	GGT6	VGNC	VGNC:104603
Mus musculus	GGT6	MGD	MGI:1918772
Rattus norvegicus	GGT6	RGD	RGD:1303335
Canis familiaris	GGT6	VGNC	VGNC:41202

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