2. Gene
  3. GRINA - glutamate ionotropic receptor NMDA type subunit associated protein 1 Gene

GRINA - glutamate ionotropic receptor NMDA type subunit associated protein 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as LFG1; HNRGW; TMBIM3; NMDARA1

Gene ID: 2907 | Gene type: protein coding

About GRINA

Cytogenetic location: 8q24.3 Genomic coordinates (GRCh38): 8:143,990,056-143,993,415 (from NCBI)

This gene has 10 transcripts (splice variants), 192 orthologues and 5 paralogues. Ubiquitous expression in fat (RPKM 80.7), brain (RPKM 68.3) and 25 other tissues.

Summary

Predicted to enable transmembrane transporter binding activity. Predicted to act upstream of or within endoplasmic reticulum calcium ion homeostasis and negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway. Predicted to be located in Golgi apparatus and endoplasmic reticulum. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

GRINA Products(2)

mRNA Protein Name
NM_000837.2 NP_000828.1 protein lifeguard 1
NM_001009184.2 NP_001009184.1 protein lifeguard 1
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GRINA Protein Structure

Bax1-I

Bax1-I: Inhibitor of apoptosis-promoting Bax1 (159 - 365)

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  • 100
  • 200
  • 300
  • 371 a.a.
Protein Preferred Names Protein Names

protein lifeguard 1

NMDA receptor glutamate-binding subunit

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05808 GRINA Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus GRINA VGNC VGNC:67474
Bos taurus GRINA VGNC VGNC:29651
Rattus norvegicus GRINA RGD RGD:628873
Canis familiaris GRINA VGNC VGNC:41497
Mus musculus GRINA MGD MGI:1913418