TMBIM1 - transmembrane BAX inhibitor motif containing 1 Gene

Homo sapiens

Also known as LFG3; RECS1; MST100; PP1201; MSTP100

Gene ID: 64114 | Gene type: protein coding

About TMBIM1

Cytogenetic location: 2q35 Genomic coordinates (GRCh38): 2:218,274,197-218,292,503 (from NCBI)

This gene has 23 transcripts (splice variants), 254 orthologues and 5 paralogues. Ubiquitous expression in esophagus (RPKM 69.4), fat (RPKM 68.5) and 25 other tissues.

Summary

Enables death receptor binding activity. Involved in negative regulation of Fas signaling pathway; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; and negative regulation of protein localization to plasma membrane. Located in Golgi apparatus; endosome membrane; and lysosomal membrane. [provided by Alliance of Genome Resources, Apr 2022]

TMBIM1 Products(10)

mRNA	Protein	Name
NM_001321427.2	NP_001308356.1	protein lifeguard 3 isoform 1
NM_001321428.2	NP_001308357.1	protein lifeguard 3 isoform 1
NM_001321429.2	NP_001308358.1	protein lifeguard 3 isoform 1
NM_001321430.2	NP_001308359.1	protein lifeguard 3 isoform 1
NM_001321432.2	NP_001308361.1	protein lifeguard 3 isoform 1
NM_001321433.2	NP_001308362.1	protein lifeguard 3 isoform 1
NM_001321435.2	NP_001308364.1	protein lifeguard 3 isoform 1
NM_001321436.2	NP_001308365.1	protein lifeguard 3 isoform 1
NM_001321438.2	NP_001308367.1	protein lifeguard 3 isoform 2
NM_022152.6	NP_071435.2	protein lifeguard 3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables death receptor binding	IDA IDA: Inferred from direct assay	21107705	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of Fas signaling pathway	IMP IMP: Inferred from mutant phenotype	21107705	GOA
involved in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	IMP IMP: Inferred from mutant phenotype	21107705	GOA
involved in negative regulation of protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	21107705	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	21107705	GOA
located in endosome membrane	IDA IDA: Inferred from direct assay	16607040	GOA
located in lysosomal membrane	IDA IDA: Inferred from direct assay	16607040	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMBIM1 Protein Structure

Bax1-I

0
100
200
311 a.a.

Protein Preferred Names

Protein Names

protein lifeguard 3

transmembrane BAX inhibitor motif-containing protein 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14618	TMBIM1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TMBIM1	VGNC	VGNC:66232
Rattus norvegicus	TMBIM1	RGD	RGD:1359409
Canis familiaris	TMBIM1	VGNC	VGNC:49789
Macaca mulatta	TMBIM1	VGNC	VGNC:79392
Mus musculus	TMBIM1	MGD	MGI:1916910
Bos taurus	TMBIM1	VGNC	VGNC:35915

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