TMBIM1 - transmembrane BAX inhibitor motif containing 1 Gene

Homo sapiens

Also known as LFG3; RECS1; MST100; PP1201; MSTP100

Gene ID: 64114 | Gene type: protein coding

About TMBIM1

Cytogenetic location: 2q35 Genomic coordinates (GRCh38): 2:218,274,197-218,292,503 (from NCBI)

This gene has 23 transcripts (splice variants), 254 orthologues and 5 paralogues. Ubiquitous expression in esophagus (RPKM 69.4), fat (RPKM 68.5) and 25 other tissues.

Summary

Enables death receptor binding activity. Involved in negative regulation of Fas signaling pathway; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; and negative regulation of protein localization to plasma membrane. Located in Golgi apparatus; endosome membrane; and lysosomal membrane. [provided by Alliance of Genome Resources, Apr 2022]

TMBIM1 Products(10)

mRNA	Protein	Name
NM_001321427.2	NP_001308356.1	protein lifeguard 3 isoform 1
NM_001321428.2	NP_001308357.1	protein lifeguard 3 isoform 1
NM_001321429.2	NP_001308358.1	protein lifeguard 3 isoform 1
NM_001321430.2	NP_001308359.1	protein lifeguard 3 isoform 1
NM_001321432.2	NP_001308361.1	protein lifeguard 3 isoform 1
NM_001321433.2	NP_001308362.1	protein lifeguard 3 isoform 1
NM_001321435.2	NP_001308364.1	protein lifeguard 3 isoform 1
NM_001321436.2	NP_001308365.1	protein lifeguard 3 isoform 1
NM_001321438.2	NP_001308367.1	protein lifeguard 3 isoform 2
NM_022152.6	NP_071435.2	protein lifeguard 3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables death receptor binding	IDA IDA: Inferred from direct assay	21107705	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of Fas signaling pathway	IMP IMP: Inferred from mutant phenotype	21107705	GOA
involved in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	IMP IMP: Inferred from mutant phenotype	21107705	GOA
involved in negative regulation of protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	21107705	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	21107705	GOA
located in endosome membrane	IDA IDA: Inferred from direct assay	16607040	GOA
located in lysosomal membrane	IDA IDA: Inferred from direct assay	16607040	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMBIM1 Protein Structure

Bax1-I

0
100
200
311 a.a.

Protein Preferred Names

Protein Names

protein lifeguard 3

transmembrane BAX inhibitor motif-containing protein 1

TMBIM1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TMBIM1	Q969X1	TMEM242	Homo sapiens	Q9NWH2	Validated Y2H	32296183
Intra	TMBIM1	Q969X1	TMEM242	Homo sapiens	Q9NWH2	Y2H Array	32296183
Intra	TMBIM1	Q969X1	TMEM242	Homo sapiens	Q9NWH2	Y2H Prey Pooling	32296183
Intra	TMBIM1	Q969X1	RIC3	Homo sapiens	Q7Z5B4-5	Y2H Prey Pooling	32296183
Intra	TMBIM1	Q969X1	RIC3	Homo sapiens	Q7Z5B4-5	Y2H Array	32296183
Intra	TMBIM1	Q969X1	B3GALNT2	Homo sapiens	Q8NCR0	Y2H Prey Pooling	32296183
Intra	TMBIM1	Q969X1	PROK2	Homo sapiens	Q9HC23	Y2H Prey Pooling	32296183
Intra	TMBIM1	Q969X1	PROK2	Homo sapiens	Q9HC23	Validated Y2H	32296183
Intra	TMBIM1	Q969X1	PROK2	Homo sapiens	Q9HC23	Y2H Array	32296183
Intra	TMBIM1	Q969X1	GGT6	Homo sapiens	Q6P531	Y2H Prey Pooling	32296183
Intra	TMBIM1	Q969X1	GGT6	Homo sapiens	Q6P531	Y2H Array	32296183
Intra	TMBIM1	Q969X1	CD33	Homo sapiens	P20138	Y2H Prey Pooling	32296183
Intra	TMBIM1	Q969X1	CD33	Homo sapiens	P20138	Y2H Array	32296183
Intra	TMBIM1	Q969X1	SLC10A1	Homo sapiens	Q14973	Y2H Array	32296183
Intra	TMBIM1	Q969X1	SLC10A1	Homo sapiens	Q14973	Y2H Prey Pooling	32296183
Intra	TMBIM1	Q969X1	BIK	Homo sapiens	Q13323	Y2H Array	32296183
Intra	TMBIM1	Q969X1	BIK	Homo sapiens	Q13323	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14618	TMBIM1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TMBIM1	VGNC	VGNC:66232
Rattus norvegicus	TMBIM1	RGD	RGD:1359409
Canis familiaris	TMBIM1	VGNC	VGNC:49789
Macaca mulatta	TMBIM1	VGNC	VGNC:79392
Mus musculus	TMBIM1	MGD	MGI:1916910
Bos taurus	TMBIM1	VGNC	VGNC:35915

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