Cdh1 - cadherin 1 Gene

Mus musculus

Also known as Um; UVO; Ecad; ARC-1; E-cad; L-CAM

Gene ID: 12550 | Gene type: protein coding

About Cdh1

Summary

This gene encodes E-cadherin, a calcium-dependent cell adhesion molecule that functions in the establishment and maintenance of epithelial cell morphology during embryongenesis and adulthood. The encoded preproprotein undergoes proteolytic processing to generate a mature protein. Targeted mutations disrupting binding of calcium to the encoded protein in mice cause death in utero due to failed blastocyst and trophectoderm formation. This gene is located adjacent to a related cadherin gene on chromosome 8. [provided by RefSeq, Oct 2015]

Cdh1 Products(1)

mRNA	Protein	Name
NM_009864.3	NP_033994.1	cadherin-1 preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables alpha-catenin binding	IPI IPI: Inferred from physical interaction	8853988	MGI
enables beta-catenin binding	IDA IDA: Inferred from direct assay	7806582	MGI
enables beta-catenin binding	IPI IPI: Inferred from physical interaction	8853988	MGI
enables calcium ion binding	IDA IDA: Inferred from direct assay	12460580	MGI
enables cytoskeletal protein binding	IMP IMP: Inferred from mutant phenotype	2519616	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	12460580	MGI
enables molecular adaptor activity	EXP EXP: Inferred from Experiment	11121423	MGI
enables molecular adaptor activity	IDA IDA: Inferred from direct assay	11121423	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9531566	MGI
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	18794329	MGI
enables protein phosphatase binding	IPI IPI: Inferred from physical interaction	16973135	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	17507657	MGI
acts upstream of or within bicellular tight junction assembly	IMP IMP: Inferred from mutant phenotype	15775979	MGI
acts upstream of or within calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	IDA IDA: Inferred from direct assay	15023525	MGI
acts upstream of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	22766025	MGI
acts upstream of or within cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	15148305	MGI
acts upstream of or within cell-cell adhesion mediated by cadherin	IMP IMP: Inferred from mutant phenotype	17507657	MGI
acts upstream of or within cellular response to amino acid stimulus	IDA IDA: Inferred from direct assay	20548288	MGI
involved in cochlea development	IDA IDA: Inferred from direct assay	30639848	MGI
acts upstream of or within cochlea development	IMP IMP: Inferred from mutant phenotype	21925491	MGI
involved in decidualization	IMP IMP: Inferred from mutant phenotype	22378759	MGI
involved in embryo implantation	IMP IMP: Inferred from mutant phenotype	22378759	MGI
acts upstream of or within epithelial cell morphogenesis	IMP IMP: Inferred from mutant phenotype	22766025	MGI
acts upstream of or within establishment of skin barrier	IMP IMP: Inferred from mutant phenotype	15775979	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	15775979	MGI
acts upstream of or within intestinal epithelial cell development	IMP IMP: Inferred from mutant phenotype	22766025	MGI
acts upstream of or within negative regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	22766025	MGI
acts upstream of or within negative regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	22766025	MGI
acts upstream of or within negative regulation of protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	17507657	MGI
acts upstream of or within negative regulation of protein processing	IMP IMP: Inferred from mutant phenotype	17344476	MGI
acts upstream of or within positive regulation of cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	2519616	MGI
involved in protein localization to plasma membrane	IDA IDA: Inferred from direct assay	7806582	MGI
acts upstream of or within regulation of branching involved in salivary gland morphogenesis	IMP IMP: Inferred from mutant phenotype	18816447	MGI
acts upstream of or within regulation of cysteine-type endopeptidase activity involved in apoptotic process	IDA IDA: Inferred from direct assay	15192701	MGI
acts upstream of or within regulation of neuron migration	IDA IDA: Inferred from direct assay	23434913	MGI
acts upstream of or within regulation of protein localization	IMP IMP: Inferred from mutant phenotype	15775979	MGI
acts upstream of or within regulation of protein localization to cell surface	IMP IMP: Inferred from mutant phenotype	15775979	MGI
acts upstream of or within salivary gland cavitation	IMP IMP: Inferred from mutant phenotype	18816447	MGI
acts upstream of or within sensory perception of sound	IMP IMP: Inferred from mutant phenotype	21925491	MGI
acts upstream of or within trophectodermal cell differentiation	IMP IMP: Inferred from mutant phenotype	17138661	MGI
involved in uterine epithelium development	IMP IMP: Inferred from mutant phenotype	22378759	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in Schmidt-Lanterman incisure	IDA IDA: Inferred from direct assay	20237282	MGI
located in adherens junction	IDA IDA: Inferred from direct assay	8582267	MGI
located in apical junction complex	IDA IDA: Inferred from direct assay	17130295	MGI
located in apical part of cell	IDA IDA: Inferred from direct assay	14758363	MGI
located in axon	IDA IDA: Inferred from direct assay	17392463	MGI
located in axon terminus	IDA IDA: Inferred from direct assay	17392463	MGI
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	15788452	MGI
part of catenin complex	IDA IDA: Inferred from direct assay	8853988	MGI
part of catenin complex	IMP IMP: Inferred from mutant phenotype	11121423	MGI
located in cell periphery	IDA IDA: Inferred from direct assay	19289495	MGI
located in cell surface	IDA IDA: Inferred from direct assay	11511678	MGI
located in cell-cell junction	IDA IDA: Inferred from direct assay	9864371	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	23637336	MGI
part of flotillin complex	IDA IDA: Inferred from direct assay	24046456	MGI
located in lateral loop	IDA IDA: Inferred from direct assay	20237282	MGI
located in microvillus	IDA IDA: Inferred from direct assay	33129760	MGI
located in node of Ranvier	IDA IDA: Inferred from direct assay	20237282	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	8853988	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

cadherin-1

E-cadherin	epithelial cadherin
uvomorulin

Recombinant Cdh1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P700008	Cadherin-1/CD324 Protein, Mouse (HEK293, C-His)	P09803 (D157-V709)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13067	Celastrol		99.90%	Unkown
HY-13255	TAME	Inhibitor	99.51%	Unkown
HY-13255A	TAME hydrochloride	Inhibitor	98.31%	Unkown
HY-145268	SLEC-11		/	Unkown
HY-145269	AL-GDa62		/	Unkown
HY-RS02320	CDH1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cdh1	NCBI	NCBI:999
Macaca fascicularis	Cdh1	NCBI	NCBI:102143513
Rattus norvegicus	Cdh1	NCBI	NCBI:83502
Macaca mulatta	Cdh1	NCBI	NCBI:704387

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