2. Gene
  3. Cdh1 - cadherin 1 Gene

Cdh1 - cadherin 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 83502 | Gene type: protein coding

About Cdh1

Summary

Predicted to enable several functions, including GTPase activating protein binding activity; alpha-catenin binding activity; and ankyrin binding activity. Involved in several processes, including nervous system development; regulation of protein catabolic process at postsynapse, modulating synaptic transmission; and response to toxic substance. Located in cytoplasm and plasma membrane. Is active in glutamatergic synapse and postsynapse. Used to study hepatocellular carcinoma and lung adenocarcinoma. Biomarker of pulmonary fibrosis and urinary bladder Cancer. Human ortholog(s) of this gene implicated in several diseases, including blepharocheilodontic syndrome 1; breast Cancer (multiple); cervix uteri carcinoma in situ; gastrointestinal system Cancer (multiple); and reproductive organ Cancer (multiple). Orthologous to human CDH1 (cadherin 1). [provided by Alliance of Genome Resources, Apr 2022]

Cdh1 Products(1)

mRNA Protein Name
NM_031334.1 NP_112624.1 cadherin-1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables beta-catenin binding IPI
IPI: Inferred from physical interaction
12960056 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
12639940 RGD
enables protein tyrosine kinase binding IPI
IPI: Inferred from physical interaction
12700184 RGD
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of axon extension IMP
IMP: Inferred from mutant phenotype
23226367 RGD
involved in neuron projection development IEP
IEP: Inferred from expression pattern
12387456 RGD
involved in pituitary gland development IEP
IEP: Inferred from expression pattern
17373711 RGD
involved in regulation of protein catabolic process at postsynapse, modulating synaptic transmission IDA
IDA: Inferred from direct assay
21186356 RGD
involved in regulation of protein catabolic process at postsynapse, modulating synaptic transmission IEP
IEP: Inferred from expression pattern
21186356 RGD
involved in regulation of protein catabolic process at postsynapse, modulating synaptic transmission IMP
IMP: Inferred from mutant phenotype
21186356 RGD
involved in response to Gram-positive bacterium IEP
IEP: Inferred from expression pattern
20501441 RGD
involved in response to heparin IEP
IEP: Inferred from expression pattern
16997938 RGD
involved in response to toxic substance IEP
IEP: Inferred from expression pattern
17120308 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
16671876 RGD
involved in synapse assembly IMP
IMP: Inferred from mutant phenotype
12123610 RGD
Cellular Component GO Annotation Evidence Reference Source
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
21186356 RGD
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
21186356 RGD
is active in postsynapse IDA
IDA: Inferred from direct assay
21186356 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cadherin-1

E-cadherin

epithelial cadherin

uvomorulin

Recombinant Cdh1 Proteins

Cat. No. Product Name Accession Purity
HY-P74367 Cadherin-1/CD324 Protein, Rat (HEK293, His) Q9R0T4 (Q24-A713) ≥95%
HY-P74368 Cadherin-1/CD324 Protein, Rat (HEK293, Fc) Q9R0T4 (Q24-A713) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13067 Celastrol 99.90% Unkown
HY-13255 TAME Inhibitor 99.51% Unkown
HY-13255A TAME hydrochloride Inhibitor 98.31% Unkown
HY-RS02320 CDH1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-145268 SLEC-11 Inhibitor / Unkown
HY-145269 AL-GDa62 Inhibitor / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P990362 Anti-CDH1/E-cadherin/CD324 Antibody / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cdh1 NCBI NCBI:999
Macaca fascicularis Cdh1 NCBI NCBI:102143513
Mus musculus Cdh1 NCBI NCBI:12550
Macaca mulatta Cdh1 NCBI NCBI:704387