2. Gene
  3. SHE - Src homology 2 domain containing E Gene

SHE - Src homology 2 domain containing E Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 126669 | Gene type: protein coding

About SHE

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:154,469,637-154,502,412 (from NCBI)

This gene has 3 transcripts (splice variants), 252 orthologues and 3 paralogues. Broad expression in testis (RPKM 8.7), lung (RPKM 6.4) and 22 other tissues.

Summary

Predicted to enable phosphotyrosine residue binding activity. [provided by Alliance of Genome Resources, Apr 2022]

SHE Products(1)

mRNA Protein Name
NM_001010846.3 NP_001010846.1 SH2 domain-containing adapter protein E
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
24728074 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SHE Protein Structure

SH2

SH2: SH2 domain (395 - 471)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 495 a.a.
Protein Preferred Names Protein Names

SH2 domain-containing adapter protein E

SHE Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
SHE Q5VZ18 AR Homo sapiens P10275
FPS
24728074
Intra
SHE Q5VZ18 FHL3 Homo sapiens Q13643
Y2H Array
32296183
Intra
SHE Q5VZ18 FHL3 Homo sapiens Q13643
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Blepharoconjunctivitis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-161910 SH-E4A-66 Inhibitor / Unkown
HY-P5925 Ssm spooky toxin Inhibitor / Unkown
HY-RS12862 SHE Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta SHE VGNC VGNC:77317
Mus musculus SHE MGD MGI:1099462
Rattus norvegicus SHE RGD RGD:1583215
Canis familiaris SHE VGNC VGNC:46146
Bos taurus SHE VGNC VGNC:34595
Felis catus SHE VGNC VGNC:65122
Others SHE NCBI