Patj - PATJ, crumbs cell polarity complex component Gene

Mus musculus

Also known as Cipp; Inadl

Gene ID: 12695 | Gene type: protein coding

About Patj

Summary

This gene encodes a multivalent PDZ domain protein, which is expressed exclusively in brain and kidney. This protein selectively interacts with inward rectifier K+ (Kir) family members, N-methyl-D-aspartate receptor subunits, neurexins and neuroligins, as well as cell surface molecules enriched in synaptic membranes. Thus, this protein may serve as a scaffold that brings structurally diverse but functionally connected proteins into close proximity at the synapse. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Patj Products(5)

mRNA	Protein	Name
NM_001005784.1	NP_001005784.1	inaD-like protein isoform 2
NM_001005787.1	NP_001005787.1	inaD-like protein isoform 4
NM_001355177.1	NP_001342106.1	inaD-like protein isoform 5
NM_007704.2	NP_031730.1	inaD-like protein isoform 3
NM_172696.2	NP_766284.2	inaD-like protein isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	9647694	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in apical part of cell	IDA IDA: Inferred from direct assay	25636444	MGI
located in apical part of cell	IDA IDA: Inferred from direct assay	14758363	MGI
part of subapical complex	IDA IDA: Inferred from direct assay	16885194	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

inaD-like protein

PALS1-associated tight junction protein	channel-interacting PDZ domain protein
channel-interacting PDZ domain-containing protein	inactivation no after-potential D-like protein
novel ankyrin-repeat protein	protein associated to tight junctions

Patj Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Patj	Q63ZW7	Grin2a	Mus musculus	P35436	Pull Down	9647694
Cross	Patj	Q63ZW7	KCNJ15	Homo sapiens	Q99712	Pull Down	9647694
Cross	Patj	Q63ZW7	KCNJ15	Homo sapiens	Q99712	Y2H	9647694
Cross	Patj	Q63ZW7	Grin2b	Rattus norvegicus	Q00960	Pull Down	9647694
Cross	Patj	Q63ZW7	Grin2b	Rattus norvegicus	Q00960	Y2H	9647694
Cross	Patj	Q63ZW7	Grin2c	Rattus norvegicus	Q00961	Y2H	9647694
Cross	Patj	Q63ZW7	Grin2c	Rattus norvegicus	Q00961	Pull Down	9647694
Cross	Patj	Q63ZW7	Grin2d	Rattus norvegicus	Q62645	Pull Down	9647694
Cross	Patj	Q63ZW7	Grin2d	Rattus norvegicus	Q62645	Y2H	9647694

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10083	PATJ Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Patj	NCBI	NCBI:10207

Name
Email *

	Sorry, but the email address you supplied was invalid.