Grin2a - glutamate receptor, ionotropic, NMDA2A (epsilon 1) Gene

Mus musculus

Also known as NR2A; GluN2A; NMDAR2A; GluRepsilon1

Gene ID: 14811 | Gene type: protein coding

About Grin2a

Summary

Enables NMDA glutamate receptor activity and Calcium Channel activity. Involved in regulation of synaptic plasticity. Acts upstream of or within several processes, including excitatory postsynaptic potential; learning or memory; and long-term synaptic potentiation. Located in several cellular components, including glutamatergic synapse; synaptic membrane; and synaptic vesicle. Is integral component of postsynaptic density membrane. Part of NMDA selective glutamate receptor complex. Is expressed in several structures, including central nervous system; eye; hindlimb phalanx; intestine; and limb mesenchyme. Human ortholog(s) of this gene implicated in Huntington's disease; bipolar disorder; and schizophrenia. Orthologous to human GRIN2A (glutamate ionotropic receptor NMDA type subunit 2A). [provided by Alliance of Genome Resources, Apr 2022]

Grin2a Products(1)

mRNA	Protein	Name
NM_008170.4	NP_032196.2	glutamate receptor ionotropic, NMDA 2A precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
contributes to NMDA glutamate receptor activity	IGI IGI: Inferred from genetic interaction	1374164	MGI
enables NMDA glutamate receptor activity	IGI IGI: Inferred from genetic interaction	1377365	MGI
enables NMDA glutamate receptor activity	IMP IMP: Inferred from mutant phenotype	7816096	MGI
contributes to calcium channel activity	IGI IGI: Inferred from genetic interaction	1374164	MGI
enables calcium channel activity	IMP IMP: Inferred from mutant phenotype	11160454	MGI
enables monoatomic cation channel activity	IMP IMP: Inferred from mutant phenotype	8699248	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9003035	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within calcium ion transport	IGI IGI: Inferred from genetic interaction	1374164	MGI
acts upstream of or within calcium ion transport	IMP IMP: Inferred from mutant phenotype	11160454	MGI
acts upstream of or within chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	9147327	MGI
NOT acts upstream of or within detection of mechanical stimulus involved in sensory perception of pain	IMP IMP: Inferred from mutant phenotype	16190898	MGI
acts upstream of or within directional locomotion	IGI IGI: Inferred from genetic interaction	8987814	MGI
acts upstream of or within dopamine metabolic process	IMP IMP: Inferred from mutant phenotype	11160454	MGI
acts upstream of or within excitatory postsynaptic potential	IGI IGI: Inferred from genetic interaction	8987814	MGI
acts upstream of or within excitatory postsynaptic potential	IMP IMP: Inferred from mutant phenotype	8699248	MGI
involved in glutamate receptor signaling pathway	IDA IDA: Inferred from direct assay	25645137	MGI
acts upstream of or within learning	IMP IMP: Inferred from mutant phenotype	9427357	MGI
acts upstream of or within learning or memory	IMP IMP: Inferred from mutant phenotype	9712642	MGI
acts upstream of or within locomotion	IMP IMP: Inferred from mutant phenotype	11160454	MGI
acts upstream of or within long-term synaptic potentiation	IGI IGI: Inferred from genetic interaction	20661302	MGI
acts upstream of or within long-term synaptic potentiation	IMP IMP: Inferred from mutant phenotype	16901514	MGI
acts upstream of or within memory	IMP IMP: Inferred from mutant phenotype	9458051	MGI
involved in modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	12427824	MGI
acts upstream of or within negative regulation of protein catabolic process	IGI IGI: Inferred from genetic interaction	15317856	MGI
acts upstream of or within neurogenesis	IMP IMP: Inferred from mutant phenotype	12941447	MGI
acts upstream of or within positive regulation of apoptotic process	IGI IGI: Inferred from genetic interaction	17803966	MGI
acts upstream of protein catabolic process	IGI IGI: Inferred from genetic interaction	15317856	MGI
acts upstream of or within protein localization to postsynaptic membrane	IGI IGI: Inferred from genetic interaction	15317856	MGI
acts upstream of or within protein localization to postsynaptic membrane	IMP IMP: Inferred from mutant phenotype	15317856	MGI
acts upstream of or within regulation of membrane potential	IMP IMP: Inferred from mutant phenotype	7816096	MGI
acts upstream of or within regulation of postsynaptic membrane potential	IMP IMP: Inferred from mutant phenotype	16157280	MGI
involved in regulation of synaptic plasticity	IDA IDA: Inferred from direct assay	25645137	MGI
involved in regulation of synaptic plasticity	IMP IMP: Inferred from mutant phenotype	12427824	MGI
acts upstream of or within response to amphetamine	IMP IMP: Inferred from mutant phenotype	15731593	MGI
acts upstream of or within response to ethanol	IMP IMP: Inferred from mutant phenotype	11530236	MGI
acts upstream of or within response to wounding	IGI IGI: Inferred from genetic interaction	9512392	MGI
acts upstream of or within response to wounding	IMP IMP: Inferred from mutant phenotype	9822733	MGI
acts upstream of or within response to xenobiotic stimulus	IMP IMP: Inferred from mutant phenotype	14750973	MGI
acts upstream of or within sensory perception of pain	IMP IMP: Inferred from mutant phenotype	10694228	MGI
acts upstream of or within serotonin metabolic process	IMP IMP: Inferred from mutant phenotype	11160454	MGI
acts upstream of or within sleep	IMP IMP: Inferred from mutant phenotype	12754515	MGI
acts upstream of or within startle response	IGI IGI: Inferred from genetic interaction	14985927	MGI
NOT acts upstream of or within startle response	IMP IMP: Inferred from mutant phenotype	9718984	MGI
acts upstream of or within startle response	IMP IMP: Inferred from mutant phenotype	11488959	MGI
acts upstream of or within visual learning	IMP IMP: Inferred from mutant phenotype	7816096	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of NMDA selective glutamate receptor complex	IPI IPI: Inferred from physical interaction	7929101	MGI
located in cell surface	IDA IDA: Inferred from direct assay	17229826	MGI
located in cell surface	IMP IMP: Inferred from mutant phenotype	17229826	MGI
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	16814779	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	19726645	MGI
located in membrane	IDA IDA: Inferred from direct assay	8840015	MGI
located in neuron projection	IDA IDA: Inferred from direct assay	21558424	MGI
located in neuron projection	IMP IMP: Inferred from mutant phenotype	21558424	MGI
located in postsynapse	IDA IDA: Inferred from direct assay	33158444	MGI
is active in postsynaptic density	IDA IDA: Inferred from direct assay	21664258	MGI
located in postsynaptic density	IDA IDA: Inferred from direct assay	17114649	MGI
is active in postsynaptic density membrane	IDA IDA: Inferred from direct assay	19726645	MGI
located in postsynaptic membrane	IDA IDA: Inferred from direct assay	12103442	MGI
located in presynaptic membrane	IDA IDA: Inferred from direct assay	16157280	MGI
located in synapse	IDA IDA: Inferred from direct assay	14622577	MGI
located in synaptic membrane	IDA IDA: Inferred from direct assay	26609151	MGI
located in synaptic vesicle	IDA IDA: Inferred from direct assay	20418887	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

glutamate receptor ionotropic, NMDA 2A

N-methyl D-aspartate receptor subtype 2A

glutamate [NMDA] receptor subunit epsilon-1

Grin2a Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Grin2a	P35436	Dlg4	Mus musculus	Q62108	Anti Tag CoIP	16332682
Intra	Grin2a	P35436	Dlg4	Mus musculus	Q62108	Anti Bait CoIP	31746486
Intra	Grin2a	P35436	Dlg4	Mus musculus	Q62108	Y2H	9647694
Intra	Grin2a	P35436	Dlg4	Mus musculus	Q62108	Crosslink	28713243
Intra	Grin2a	P35436	Dlg4	Mus musculus	Q62108	Anti Bait CoIP	19240213
Intra	Grin2a	P35436	Dlg4	Mus musculus	Q62108	Anti Bait CoIP	19243221
Intra	Grin2a	P35436	Patj	Mus musculus	Q63ZW7	Y2H	9647694

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05804	GRIN2A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Grin2a	NCBI	NCBI:2903

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