Ccr4 - chemokine (C-C motif) receptor 4 Gene

Mus musculus

Also known as LESTR; Sdf1r; CHEMR1; Cmkbr4; C-C CKR-4

Gene ID: 12773 | Gene type: protein coding

About Ccr4

Chromosome 9: 114,319,384-114,333,984 reverse strand.GRCm39:CM001002.3

This gene has 3 transcripts (splice variants), 114 orthologues, 25 paralogues and is associated with 29 phenotypes. Biased expression in thymus adult (RPKM 1.4), testis adult (RPKM 1.5) and 2 other tissues.

Summary

Enables C-C Chemokine Receptor activity. Acts upstream of or within several processes, including homeostasis of number of cells; neuron migration; and tolerance induction. Located in external side of plasma membrane. Is expressed in several structures, including central nervous system; intestine; pyloric antrum; reproductive system; and thymus. Orthologous to human CCR4 (C-C motif Chemokine Receptor 4). [provided by Alliance of Genome Resources, Apr 2022]

Ccr4 Products(2)

mRNA	Protein	Name
NM_009916.2	NP_034046.2	C-C chemokine receptor type 4
NM_009916.2	NP_034046.2	C-C chemokine receptor type 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables C-C chemokine receptor activity	IMP IMP: Inferred from mutant phenotype	10811868	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within chemotaxis	IMP IMP: Inferred from mutant phenotype	10811868	MGI
acts upstream of or within homeostasis of number of cells	IMP IMP: Inferred from mutant phenotype	24069263	MGI
acts upstream of or within inflammatory response	IMP IMP: Inferred from mutant phenotype	10811868	MGI
acts upstream of or within interneuron migration	IMP IMP: Inferred from mutant phenotype	16262623	MGI
acts upstream of or within neuron migration	IMP IMP: Inferred from mutant phenotype	16262623	MGI
acts upstream of or within tolerance induction	IMP IMP: Inferred from mutant phenotype	15809349	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	19008373	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ccr4 Protein Structure

7tmA_Chemokine_R

0
100
200
300
360 a.a.

Protein Preferred Names

Protein Names

C-C chemokine receptor type 4

chemokine (C-C) receptor 4	fusin
leukocyte-expressed seven-transmembrane-domain receptor

Related Agents

Approval

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99253	Mogamulizumab	Inhibitor	95.00%	Unkown

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-148074	Zelnecirnon	Inhibitor	99.84%	Phase 2
HY-148494	Tivumecirnon	Antagonist	99.85%	Phase 2
HY-100183	GSK2239633A	Antagonist	99.81%	Phase 1

Pre-clinical Phase

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-119293	K777	Antagonist	99.77%	Unkown
HY-U00064	AZD2098	Inhibitor	99.84%	Unkown
HY-103364	C-021	Inhibitor	99.95%	Unkown
HY-103364A	C-021 dihydrochloride	Antagonist	99.92%	Unkown
HY-P3982	CKLF1-C19	Chemical	99.76%	Unkown
HY-P3418	CKLF1-C27	Inhibitor	98.46%	Unkown
HY-157453	CCR4 antagonist 4	Antagonist	99.72%	Unkown
HY-131349	CCR4-351	Antagonist	98.95%	Unkown
HY-147385	CCR4 antagonist 3	Antagonist	99.94%	Unkown
HY-131349A	CCR4-351 hydrochloride	Antagonist	98.37%	Unkown
HY-P3418A	CKLF1-C27 TFA	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ccr4	NCBI	NCBI:1233

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