2. Gene
  3. TANGO2 - transport and golgi organization 2 homolog Gene

TANGO2 - transport and golgi organization 2 homolog Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as MECRCN; C22orf25

Gene ID: 128989 | Gene type: protein coding

About TANGO2

Cytogenetic location: 22q11.21 Genomic coordinates (GRCh38): 22:20,017,023-20,067,164 (from NCBI)

This gene has 26 transcripts (splice variants), 211 orthologues and is associated with 3 phenotypes. Ubiquitous expression in heart (RPKM 11.7), bone marrow (RPKM 9.2) and 25 other tissues.

Summary

This gene belongs to the transport and Golgi organization family, whose members are predicted to play roles in secretory protein loading in the endoplasmic reticulum. Depletion of this gene in Drosophila S2 cells causes fusion of the Golgi with the ER. In mouse tissue culture cells, this protein co-localizes with a mitochondrially targeted mCherry protein and displays very low levels of co-localization with Golgi and peroxisomes. Allelic variants of this gene are associated with rhabdomyolysis, metabolic crises with encephalopathy, and cardiac arrhythmia. [provided by RefSeq, Apr 2016]

TANGO2 Products(34)

mRNA Protein Name
NM_001283106.3 NP_001270035.1 transport and Golgi organization protein 2 homolog isoform a
NM_001283116.3 NP_001270045.1 transport and Golgi organization protein 2 homolog isoform a
NM_001283129.3 NP_001270058.1 transport and Golgi organization protein 2 homolog isoform b
NM_001283148.3 NP_001270077.1 transport and Golgi organization protein 2 homolog isoform c
NM_001283154.3 NP_001270083.1 transport and Golgi organization protein 2 homolog isoform c
NM_001283179.3 NP_001270108.1 transport and Golgi organization protein 2 homolog isoform d
NM_001283186.3 NP_001270115.1 transport and Golgi organization protein 2 homolog isoform d
NM_001283199.3 NP_001270128.1 transport and Golgi organization protein 2 homolog isoform e
NM_001283215.3 NP_001270144.1 transport and Golgi organization protein 2 homolog isoform f
NM_001283235.3 NP_001270164.1 transport and Golgi organization protein 2 homolog isoform g
NM_001283248.3 NP_001270177.1 transport and Golgi organization protein 2 homolog isoform h
NM_001322141.2 NP_001309070.1 transport and Golgi organization protein 2 homolog isoform i
NM_001322142.2 NP_001309071.1 transport and Golgi organization protein 2 homolog isoform j
NM_001322143.2 NP_001309072.1 transport and Golgi organization protein 2 homolog isoform b
NM_001322144.2 NP_001309073.1 transport and Golgi organization protein 2 homolog isoform l
NM_001322145.2 NP_001309074.1 transport and Golgi organization protein 2 homolog isoform m
NM_001322146.2 NP_001309075.1 transport and Golgi organization protein 2 homolog isoform k
NM_001322147.2 NP_001309076.1 transport and Golgi organization protein 2 homolog isoform m
NM_001322148.2 NP_001309077.1 transport and Golgi organization protein 2 homolog isoform n
NM_001322149.2 NP_001309078.1 transport and Golgi organization protein 2 homolog isoform r
NM_001322150.2 NP_001309079.1 transport and Golgi organization protein 2 homolog isoform o
NM_001322153.2 NP_001309082.1 transport and Golgi organization protein 2 homolog isoform o
NM_001322155.2 NP_001309084.1 transport and Golgi organization protein 2 homolog isoform o
NM_001322160.2 NP_001309089.1 transport and Golgi organization protein 2 homolog isoform p
NM_001322163.2 NP_001309092.1 transport and Golgi organization protein 2 homolog isoform d
NM_001322166.2 NP_001309095.1 transport and Golgi organization protein 2 homolog isoform d
NM_001322167.2 NP_001309096.1 transport and Golgi organization protein 2 homolog isoform d
NM_001322169.2 NP_001309098.1 transport and Golgi organization protein 2 homolog isoform q
NM_001322171.2 NP_001309100.1 transport and Golgi organization protein 2 homolog isoform g
NM_001322172.2 NP_001309101.1 transport and Golgi organization protein 2 homolog isoform g
NM_001322173.2 NP_001309102.1 transport and Golgi organization protein 2 homolog isoform g
NM_001322174.2 NP_001309103.1 transport and Golgi organization protein 2 homolog isoform g
NM_001322175.2 NP_001309104.1 transport and Golgi organization protein 2 homolog isoform g
NM_152906.7 NP_690870.3 transport and Golgi organization protein 2 homolog isoform a
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
Cellular Component GO Annotation Evidence Reference Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
26805781 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
31276219 GOA
located in cytosol IDA
IDA: Inferred from direct assay
32909282 GOA
located in mitochondrion IDA
IDA: Inferred from direct assay
32909282 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transport and Golgi organization protein 2 homolog

TANGO2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
TANGO2 Q6ICL3 SH3GL2 Homo sapiens Q99962
Anti Tag CoIP
33961781
Intra
TANGO2 Q6ICL3 SH3GL2 Homo sapiens Q99962
Anti Tag CoIP
28514442
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Metabolic Crises, Recurrent, With Rhabdomyolysis, Cardiac Arrhythmias, And Neurodegeneration

Metabolic Encephalomyopathic Crises, Recurrent, With Rhabdomyolysis, Cardiac Arrhythmias, And Neurodegeneration

MECRCN

Rhabdomyolysis
Tango2-Related Metabolic Encephalopathy And Arrhythmias

Recurrent Metabolic Encephalomyopathic Crises-Rhabdomyolysis-Cardiac Arrhythmia-Intellectual Disability Syndrome

Tango2

Metabolic Encephalomyopathic Crises, Recurrent, With Rhabdomyolysis, Cardiac Arrhythmias, And Neurodegeneration

Tango2 Related Disease

Tango2-Related Metabolic Encephalopathy-Arrhythmia Syndrome

Tango2-Related Disorder
Episodic Ataxia

Isaacs Syndrome

Neuromyotonia

Isaacs' Syndrome

Acquired Neuromyotonia

Continuous Muscle Fiber Activity Syndrome

Quantal Squander Syndrome

Isaacs-Mertens Syndrome

Ea Syndrome

Episodic Ataxia Syndrome

Isaac Syndrome

Isaac'S-Merten'S Syndrome

Isaac-Mertens Syndrome

Peripheral Nerve Hyperexcitability

Ea

Peripheral Nerve Hyperexcitability Syndrome

Ataxia, Episodic

Isaacs Neuromyotonia

Continuous Muscle Fibre Activity
Hereditary Episodic Ataxia
Pitt-Hopkins-Like Syndrome 2

PTHSL2

Mesh

D006985

Mesh

D008607
Treacher Collins Syndrome 3

TCS3

Mandibulofacial Dysostosis, Treacher Collins Type, Autosomal Recessive

Mandibulofacial Dysostosis Treacher Collins Type Autosomal Recessive
Lissencephaly 6

Lis6
Ectodermal Dysplasia 14, Hair/Tooth Type With Or Without Hypohidrosis

ECTD14

Ectodermal Dysplasia 14

Ectn14
Leukodystrophy, Hypomyelinating, 11

Hypomyelinating Leukodystrophy 11

HLD11

4h Leukodystrophy 3

Leukodystrophy, Hypomyelinating, Type 11
Chromosome 6q24-Q25 Deletion Syndrome

Chromosome 6q25-Q25 Deletion Syndrome

6q25 Microdeletion Syndrome

Monosomy 6q25

Del(6)(Q25)
Alternating Hemiplegia Of Childhood

Alternating Hemiplegia

Ahc

Alternating Hemiplegia Syndrome

Hemiplegia, Alternating, Of Childhood

Hemiplegia, Crossed
Velocardiofacial Syndrome

Shprintzen Syndrome

VCFS

Chromosome 22q11.2 Deletion Syndrome

Vcf Syndrome

Shprintzen Vcf Syndrome

Vcf-Velocardiofacial Syndrome

Velo-Cardio-Facial Syndrome

Digeorge Syndrome

22q11 Deletion Syndrome

Conotruncal Anomaly Face Syndrome
Chromosome 22q11.2 Deletion Syndrome, Distal

22q11.2 Deletion Syndrome

Autosomal Dominant Opitz G/Bbb Syndrome

Catch22

Cayler Cardiofacial Syndrome

Conotruncal Anomaly Face Syndrome

Digeorge Syndrome

Sedlackova Syndrome

Shprintzen Syndrome

Velocardiofacial Syndrome

22q11.2 Distal Deletion Syndrome

Distal 22q11.2 Microdeletion Syndrome

22q11.2ds

Vcfs

Velo-Cardio-Facial Syndrome

Distal Chromosome 22q11.2 Deletion Syndrome

Chromosome 22q11.2 Deletion Syndrome Distal

Chromosome 22q11.2 Deletion Syndrome

Deletion 22q11.2 Syndrome

22q11ds

Catch 22

Digeorge Sequence

Microdeletion 22q11.2

Monosomy 22q11

Takao Syndrome

Distal Del(22)(Q11.2)

Distal Monosomy 22q11.2

Catch 22 Syndrome

Chromosome Deletion Syndrome 22q11.2, Distal
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14196 TANGO2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus TANGO2 RGD RGD:1310348
Canis familiaris TANGO2 VGNC VGNC:52971
Felis catus TANGO2 VGNC VGNC:65950
Mus musculus TANGO2 MGD MGI:101825
Bos taurus TANGO2 VGNC VGNC:106964
Macaca mulatta TANGO2 VGNC VGNC:78209