Crebbp - CREB binding protein Gene

Mus musculus

Also known as CBP; KAT3A; CBP/p300; p300/CBP

Gene ID: 12914 | Gene type: protein coding

About Crebbp

Chromosome 16: 3,899,192-4,031,861 reverse strand.GRCm39:CM001009.3

This gene has 8 transcripts (splice variants), 277 orthologues, 1 paralogue and is associated with 132 phenotypes. Ubiquitous expression in thymus adult (RPKM 18.7), spleen adult (RPKM 14.3) and 28 other tissues.

Summary

Enables several functions, including DNA-binding transcription factor binding activity; TFIIB-class transcription factor binding activity; and disordered domain specific binding activity. Involved in several processes, including cellular response to virus; face morphogenesis; and negative regulation of interferon-beta production. Acts upstream of or within cellular response to hepatocyte growth factor stimulus; germ-line stem cell population maintenance; and regulation of gene expression. Located in chromatin and nucleus. Part of RNA polymerase II transcription regulator complex; Histone Acetyltransferase complex; and outer kinetochore. Is expressed in several structures, including alimentary system; embryo ectoderm; genitourinary system; heart; and skin. Used to study Rubinstein-Taybi syndrome; acute myeloid leukemia; autism spectrum disorder; and myelodysplastic syndrome. Human ortholog(s) of this gene implicated in Rubinstein-Taybi syndrome; acute lymphoblastic leukemia; and acute myeloid leukemia. Orthologous to human CREBBP (CREB binding protein). [provided by Alliance of Genome Resources, Apr 2022]

Crebbp Products(1)

mRNA	Protein	Name
NM_001025432.1	NP_001020603.1	histone lysine acetyltransferase CREBBP

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	15681609	MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	21402781	MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	7913207	MGI
enables TFIIB-class transcription factor binding	IPI IPI: Inferred from physical interaction	7913207	MGI
enables cAMP response element binding protein binding	IPI IPI: Inferred from physical interaction	9413984	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	15832170	MGI
enables disordered domain specific binding	IPI IPI: Inferred from physical interaction	11823864	MGI
enables histone acetyltransferase activity	IDA IDA: Inferred from direct assay	11115394	MGI
enables molecular adaptor activity	EXP EXP: Inferred from Experiment	11823864	MGI
contributes to protein binding	IPI IPI: Inferred from physical interaction	10215616	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9556555	MGI
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	11583620	MGI
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	7913207	MGI
enables zinc ion binding	IMP IMP: Inferred from mutant phenotype	14594809	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cellular response to hepatocyte growth factor stimulus	IDA IDA: Inferred from direct assay	21072211	MGI
involved in cellular response to virus	IMP IMP: Inferred from mutant phenotype	11583620	MGI
involved in face morphogenesis	IMP IMP: Inferred from mutant phenotype	19822209	MGI
acts upstream of or within germ-line stem cell population maintenance	IMP IMP: Inferred from mutant phenotype	17936260	MGI
involved in negative regulation of interferon-beta production	IMP IMP: Inferred from mutant phenotype	11583620	MGI
involved in negative regulation of viral process	IMP IMP: Inferred from mutant phenotype	11583620	MGI
acts upstream of or within positive regulation of CREB transcription factor activity	IDA IDA: Inferred from direct assay	7913207	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15464984	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	10733899	MGI
acts upstream of or within positive regulation of gene expression	IGI IGI: Inferred from genetic interaction	22523253	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	16012757	MGI
acts upstream of or within regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12464179	MGI
involved in regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	11583620	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of RNA polymerase II transcription regulator complex	IDA IDA: Inferred from direct assay	7913207	MGI
located in chromatin	IDA IDA: Inferred from direct assay	15187136	MGI
part of histone acetyltransferase complex	IDA IDA: Inferred from direct assay	9742083	MGI
located in nucleus	IDA IDA: Inferred from direct assay	11963968	MGI
part of outer kinetochore	IDA IDA: Inferred from direct assay	14519686	MGI
part of protein-containing complex	IMP IMP: Inferred from mutant phenotype	11823864	MGI
part of transcription regulator complex	IDA IDA: Inferred from direct assay	12464179	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Crebbp Protein Structure

zf-TAZ

KIX

PHA03247

COG5076

Bromo_cbp_like

RING_CBP-p300

PHD_CBP_p300

HAT_KAT11

ZZ_CBP

zf-TAZ

Med15

Creb_binding

0
400
800
1200
1600
2000
2441 a.a.

Protein Preferred Names

Protein Names

histone lysine acetyltransferase CREBBP

protein-lysine acetyltransferase CREBBP

Related Agents

Pre-clinical Phase

Bioactive Molecules (12)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-19999A	PF-CBP1 hydrochloride	Inhibitor	99.99%	Unkown
HY-128875	CBP/p300-IN-10	Inhibitor	98.69%	Unkown
HY-RS03156	Crebbp Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-135236	OXFBD04	Inhibitor	98.99%	Unkown
HY-114971	CREBBP-IN-1		/	Unkown
HY-116237	CREBBP-IN-9	Inhibitor	/	Unkown
HY-128362	Ep300/CREBBP-IN-8	Inhibitor	/	Unkown
HY-128363	Ep300/CREBBP-IN-2	Inhibitor	/	Unkown
HY-128364	Ep300/CREBBP-IN-3	Inhibitor	/	Unkown
HY-128367	Ep300/CREBBP-IN-4	Inhibitor	/	Unkown
HY-RS03155	CREBBP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS03157	Crebbp Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Crebbp	NCBI	NCBI:1387

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