NUP35 - nucleoporin 35 Gene

Homo sapiens

Also known as MP44; NP44; MP-44; NUP53

Gene ID: 129401 | Gene type: protein coding

About NUP35

Cytogenetic location: 2q32.1 Genomic coordinates (GRCh38): 2:183,117,514-183,161,680 (from NCBI)

This gene has 10 transcripts (splice variants) and 215 orthologues. Ubiquitous expression in testis (RPKM 6.9), adrenal (RPKM 3.5) and 25 other tissues.

Summary

This gene encodes a member of the nucleoporin family. The encoded protein contains two membrane binding regions, is localized to the nuclear rim, and is part of the nuclear pore complex. All molecules entering or leaving the nucleus either diffuse through or are actively transported by the nuclear pore complex. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 7 and 10. [provided by RefSeq, Dec 2013]

NUP35 Products(3)

mRNA	Protein	Name
NM_001287584.2	NP_001274513.1	nucleoporin NUP35 isoform b
NM_001287585.2	NP_001274514.1	nucleoporin NUP35 isoform c
NM_138285.5	NP_612142.2	nucleoporin NUP35 isoform a

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nuclear envelope	IDA IDA: Inferred from direct assay	24315095	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NUP35 Protein Structure

Nup35_RRM

0
100
200
300
326 a.a.

Protein Preferred Names

Protein Names

nucleoporin NUP35

mitotic phosphoprotein 44

NUP35 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NUP35	Q8NFH5	KCTD9	Homo sapiens	Q7L273	Validated Y2H	25416956
Intra	NUP35	Q8NFH5	KCTD9	Homo sapiens	Q7L273	Anti Tag CoIP	28514442
Intra	NUP35	Q8NFH5	KCTD9	Homo sapiens	Q7L273	Y2H Array	25416956
Intra	NUP35	Q8NFH5	KCTD9	Homo sapiens	Q7L273	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Seminal Vesicle Tumor

Tumor Of Seminal Vesicle	Seminal Vesicle Neoplasm
Seminal Vesicle Tumour	Tumour Of Seminal Vesicle

Achalasia-Addisonianism-Alacrima Syndrome

Allgrove Syndrome	Triple-A Syndrome
Achalasia-Addisonianism-Alacrimia Syndrome	Alacrima-Achalasia-Adrenal Insufficiency Neurologic Disorder
Triple A Syndrome	Aaa Syndrome
AAAS	Glucocorticoid Deficiency With Achalasia
Glucocorticoid Deficiency And Achalasia	Addisonian-Achalasia Syndrome
Hypoadrenalism With Achalasia	Alacrima-Achalasia-Addisonianism
Aaa	Acth-Resistant Adrenal Insufficiency, Achalasia And Alacrima
Achalasia Addisonianism Alacrimia Syndrome	Achalasia Alacrima Syndrome
Addisonian Achalasia Syndrome	Achalasia-Addisonian Syndrome
Achalasia-Alacrima Syndrome	2a Syndrome
3a Syndrome	4a Syndrome
Adrenal Insufficiency-Achalasia-Alacrima Syndrome	Double A Syndrome
Quaternary A Syndrome	Acth-Resistant Adrenal Insufficiency With Achalasia And Alacrima
Allgrove'S Syndrome	Adrenal Gland Hypofunction
Adrenal Cortical Hypofunction

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09693	NUP35 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	NUP35	MGD	MGI:1916732
Bos taurus	NUP35	VGNC	VGNC:32359
Macaca mulatta	NUP35	VGNC	VGNC:75486
Canis familiaris	NUP35	VGNC	VGNC:44053
Felis catus	NUP35	VGNC	VGNC:63924
Rattus norvegicus	NUP35	RGD	RGD:1303069

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