TYW5 - tRNA-yW synthesizing protein 5 Gene

Homo sapiens

Also known as hTYW5; C2orf60

Gene ID: 129450 | Gene type: protein coding

About TYW5

Cytogenetic location: 2q33.1 Genomic coordinates (GRCh38): 2:199,928,913-199,955,491 (from NCBI)

This gene has 5 transcripts (splice variants), 198 orthologues and 4 paralogues. Ubiquitous expression in bone marrow (RPKM 2.6), thyroid (RPKM 2.0) and 25 other tissues.

Summary

Enables several functions, including iron ion binding activity; protein homodimerization activity; and tRNAPhe (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase activity. Involved in wybutosine biosynthetic process. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

TYW5 Products(1)

mRNA	Protein	Name
NM_001039693.3	NP_001034782.1	tRNA wybutosine-synthesizing protein 5

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables iron ion binding	IDA IDA: Inferred from direct assay	20972222	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	20972222	GOA
enables tRNA binding	IDA IDA: Inferred from direct assay	20972222	GOA
enables tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase activity	IDA IDA: Inferred from direct assay	20739293	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in wybutosine biosynthetic process	IDA IDA: Inferred from direct assay	20739293	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TYW5 Protein Structure

Cupin_8

0
100
200
315 a.a.

Protein Preferred Names

Protein Names

tRNA wybutosine-synthesizing protein 5

jmjC domain-containing protein C2orf60

Related Diseases

Diseases

Alias

Cerebrooculofacioskeletal Syndrome 4

COFS4	Cerebro-Oculo-Facio-Skeletal Syndrome 4
Cofs Syndrome	Cerebrooculofacioskeletal Syndrome, Type 4

Mixed Sleep Apnea

Complex Sleep Apnea

Sleep Apnea, Mixed Central And Obstructive

Amyotrophic Lateral Sclerosis 7

ALS7	Amyotrophic Lateral Sclerosis Type 7

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15312	TYW5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TYW5	VGNC	VGNC:36555
Mus musculus	TYW5	MGD	MGI:1915986
Macaca mulatta	TYW5	VGNC	VGNC:99417
Canis familiaris	TYW5	VGNC	VGNC:48031
Rattus norvegicus	TYW5	RGD	RGD:1311269

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