Ctsb - cathepsin B Gene

Mus musculus

Also known as CB

Gene ID: 13030 | Gene type: protein coding

About Ctsb

Chromosome 14: 63,359,911-63,383,372 forward strand.GRCm39:CM001007.3

This gene has 3 transcripts (splice variants), 223 orthologues, 24 paralogues and is associated with 9 phenotypes. Ubiquitous expression in adrenal adult (RPKM 374.9), subcutaneous fat pad adult (RPKM 322.2) and 26 other tissues.

Summary

This gene encodes a member of the peptidase C1 family and preproprotein that is proteolytically processed to generate multiple protein products. These products include the Cathepsin B light and heavy chains, which can dimerize to generate the double chain form of the Enzyme. This Enzyme is a lysosomal cysteine protease with both endopeptidase and exopeptidase activity that may play a role in protein turnover. Homozygous knockout mice for this gene exhibit reduced pancreatic damage following induced pancreatitis and reduced hepatocyte Apoptosis in a model of liver injury. Pseudogenes of this gene have been identified in the genome. [provided by RefSeq, Aug 2015]

Ctsb Products(1)

mRNA	Protein	Name
NM_007798.3	NP_031824.1	cathepsin B preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cysteine-type endopeptidase activity	IDA IDA: Inferred from direct assay	30487519	MGI
enables cysteine-type peptidase activity	IDA IDA: Inferred from direct assay	28728022	MGI
enables endopeptidase activity	IMP IMP: Inferred from mutant phenotype	28835281	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within decidualization	IGI IGI: Inferred from genetic interaction	9310336	MGI
involved in proteolysis involved in protein catabolic process	IMP IMP: Inferred from mutant phenotype	12782676	MGI
involved in symbiont entry into host cell	IMP IMP: Inferred from mutant phenotype	15831716	MGI
involved in thyroid hormone generation	IMP IMP: Inferred from mutant phenotype	12782676	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	12782676	MGI
located in extracellular space	IDA IDA: Inferred from direct assay	12782676	MGI
located in lysosome	IDA IDA: Inferred from direct assay	9034150	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ctsb Protein Structure

Propeptide_C1

Peptidase_C1A_CathepsinB

0
100
200
300
339 a.a.

Protein Preferred Names

Protein Names

cathepsin B

cathepsin B1

Recombinant Ctsb Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7747	Cathepsin B Protein, Mouse (HEK293, His)	P10605 (H18-F339)	≥95%

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-137978A	Ezurpimtrostat hydrochloride	Inhibitor	99.29%	Phase 2
HY-137978	Ezurpimtrostat	Inhibitor	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-119293	K777		99.77%	Unkown
HY-W074890	Palmitoylglycine	Modulator	99.74%	Unkown
HY-P2780A	Cathepsin B, Human Liver		/	Unkown
HY-119293A	K777 tosylate		/	Unkown
HY-159172	HDAC3-IN-4	Inhibitor	/	Unkown
HY-RS03322	CTSB Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS03323	Ctsb Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS03324	Ctsb Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-163029	CTSL/B-IN-1	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ctsb	NCBI	NCBI:1508
Rattus norvegicus	Ctsb	NCBI	NCBI:64529

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