2. Gene
  3. NUDT16 - nudix hydrolase 16 Gene

NUDT16 - nudix hydrolase 16 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 131870 | Gene type: protein coding

About NUDT16

Cytogenetic location: 3q22.1 Genomic coordinates (GRCh38): 3:131,381,671-131,388,830 (from NCBI)

This gene has 3 transcripts (splice variants), 183 orthologues and 1 paralogue. Ubiquitous expression in fat (RPKM 14.5), kidney (RPKM 13.4) and 25 other tissues.

Summary

Enables several functions, including RNA binding activity; metal ion binding activity; and purine ribonucleoside triphosphate binding activity. Involved in IDP catabolic process; RNA metabolic process; and positive regulation of cell cycle process. Located in cytoplasm; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

NUDT16 Products(3)

mRNA Protein Name
NM_001171905.2 NP_001165376.1 U8 snoRNA-decapping enzyme isoform 3
NM_001171906.2 NP_001165377.1 U8 snoRNA-decapping enzyme isoform 1
NM_152395.3 NP_689608.2 U8 snoRNA-decapping enzyme isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity IDA
IDA: Inferred from direct assay
15053875 GOA
enables IDP phosphatase activity IDA
IDA: Inferred from direct assay
20385596 GOA
enables chloride ion binding IDA
IDA: Inferred from direct assay
29483298 GOA
enables cobalt ion binding IDA
IDA: Inferred from direct assay
17567574 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
26121039 GOA
enables mRNA binding IDA
IDA: Inferred from direct assay
21337011 GOA
enables magnesium ion binding IDA
IDA: Inferred from direct assay
17567574 GOA
enables manganese ion binding IDA
IDA: Inferred from direct assay
17567574 GOA
enables metalloexopeptidase activity IDA
IDA: Inferred from direct assay
21337011 GOA
enables phosphodiesterase decapping endonuclease activity IDA
IDA: Inferred from direct assay
29483298 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
17567574 GOA
enables snoRNA binding IDA
IDA: Inferred from direct assay
18820299 GOA
Biological Process GO Annotation Evidence Reference Source
involved in NAD-cap decapping IDA
IDA: Inferred from direct assay
32432673 GOA
involved in mRNA catabolic process IDA
IDA: Inferred from direct assay
21070968 GOA
involved in positive regulation of cell cycle process IMP
IMP: Inferred from mutant phenotype
20385596 GOA
involved in sno(s)RNA catabolic process IDA
IDA: Inferred from direct assay
15053875 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
20385596 GOA
located in nucleolus IDA
IDA: Inferred from direct assay
20385596 GOA
located in nucleus IDA
IDA: Inferred from direct assay
20385596 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NUDT16 Protein Structure

NUDIX

NUDIX: NUDIX domain (45 - 119)

  • 0
  • 100
  • 195 a.a.
Protein Preferred Names Protein Names

U8 snoRNA-decapping enzyme

IDP phosphatase

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-16965 TH287 Inhibitor 98.29% Unkown
HY-RS09666 NUDT16 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS09667 NUDT16L1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-16965A TH287 hydrochloride Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus NUDT16 RGD RGD:1311387
Canis familiaris NUDT16 VGNC VGNC:44028
Mus musculus NUDT16 MGD MGI:1922936
Bos taurus NUDT16 VGNC VGNC:32330
Felis catus NUDT16 VGNC VGNC:102790