NUDT16 - nudix hydrolase 16 Gene

Homo sapiens

Gene ID: 131870 | Gene type: protein coding

About NUDT16

Cytogenetic location: 3q22.1 Genomic coordinates (GRCh38): 3:131,381,671-131,388,830 (from NCBI)

This gene has 3 transcripts (splice variants), 183 orthologues and 1 paralogue. Ubiquitous expression in fat (RPKM 14.5), kidney (RPKM 13.4) and 25 other tissues.

Summary

Enables several functions, including RNA binding activity; metal ion binding activity; and purine ribonucleoside triphosphate binding activity. Involved in IDP catabolic process; RNA metabolic process; and positive regulation of cell cycle process. Located in cytoplasm; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

NUDT16 Products(3)

mRNA	Protein	Name
NM_001171905.2	NP_001165376.1	U8 snoRNA-decapping enzyme isoform 3
NM_001171906.2	NP_001165377.1	U8 snoRNA-decapping enzyme isoform 1
NM_152395.3	NP_689608.2	U8 snoRNA-decapping enzyme isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity	IDA IDA: Inferred from direct assay	15053875	GOA
enables IDP phosphatase activity	IDA IDA: Inferred from direct assay	20385596	GOA
enables chloride ion binding	IDA IDA: Inferred from direct assay	29483298	GOA
enables cobalt ion binding	IDA IDA: Inferred from direct assay	17567574	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	26121039	GOA
enables mRNA binding	IDA IDA: Inferred from direct assay	21337011	GOA
enables magnesium ion binding	IDA IDA: Inferred from direct assay	17567574	GOA
enables manganese ion binding	IDA IDA: Inferred from direct assay	17567574	GOA
enables metalloexopeptidase activity	IDA IDA: Inferred from direct assay	21337011	GOA
enables phosphodiesterase decapping endonuclease activity	IDA IDA: Inferred from direct assay	29483298	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	17567574	GOA
enables snoRNA binding	IDA IDA: Inferred from direct assay	18820299	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in NAD-cap decapping	IDA IDA: Inferred from direct assay	32432673	GOA
involved in mRNA catabolic process	IDA IDA: Inferred from direct assay	21070968	GOA
involved in positive regulation of cell cycle process	IMP IMP: Inferred from mutant phenotype	20385596	GOA
involved in sno(s)RNA catabolic process	IDA IDA: Inferred from direct assay	15053875	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	20385596	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	20385596	GOA
located in nucleus	IDA IDA: Inferred from direct assay	20385596	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NUDT16 Protein Structure

NUDIX

0
100
195 a.a.

Protein Preferred Names

Protein Names

U8 snoRNA-decapping enzyme

IDP phosphatase

NUDT16 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NUDT16	Q96DE0	MTIF2	Homo sapiens	P46199	Anti Tag CoIP	33961781
Intra	NUDT16	Q96DE0	NUDT16	Homo sapiens	Q96DE0	X-Ray Diffraction	26121039
Intra	NUDT16	Q96DE0	ACSF2	Homo sapiens	Q96CM8	Anti Tag CoIP	33961781
Intra	NUDT16	Q96DE0	D2HGDH	Homo sapiens	Q8N465	Anti Tag CoIP	33961781
Intra	NUDT16	Q96DE0	NUDT16	Homo sapiens	Q96DE0	GMS	26121039
Intra	NUDT16	Q96DE0	ATP12A	Homo sapiens	P54707	Anti Tag CoIP	33961781
Intra	NUDT16	Q96DE0	COL20A1	Homo sapiens	Q9P218	Anti Tag CoIP	33961781
Intra	NUDT16	Q96DE0	UBR2	Homo sapiens	Q8IWV8	Anti Tag CoIP	33961781
Intra	NUDT16	Q96DE0	BCKDK	Homo sapiens	O14874	Anti Tag CoIP	33961781
Intra	NUDT16	Q96DE0	CRAT	Homo sapiens	P43155	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-16965	TH287	Inhibitor	98.29%	Unkown
HY-RS09666	NUDT16 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09667	NUDT16L1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-16965A	TH287 hydrochloride	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	NUDT16	RGD	RGD:1311387
Canis familiaris	NUDT16	VGNC	VGNC:44028
Mus musculus	NUDT16	MGD	MGI:1922936
Bos taurus	NUDT16	VGNC	VGNC:32330
Felis catus	NUDT16	VGNC	VGNC:102790

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