Dnm1 - dynamin 1 Gene

Mus musculus

Also known as Dnm; Ftfl; mKIAA4093

Gene ID: 13429 | Gene type: protein coding

About Dnm1

Summary

This gene encodes a member of the Dynamin subfamily of GTP-binding proteins. The encoded protein is a GTPase which is required for membrane recycling, including vesicle endocytosis in neurons. It may also be involved in cellular fission via association with microtubules and actin filaments. Mutations in this gene have been shown to cause seizures. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]

Dnm1 Products(3)

mRNA	Protein	Name
NM_001301737.1	NP_001288666.1	dynamin-1 isoform 2
NM_001368679.1	NP_001355608.1	dynamin-1 isoform 3
NM_010065.3	NP_034195.2	dynamin-1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GDP binding	IDA IDA: Inferred from direct assay	20428113	MGI
enables GTPase activity	IDA IDA: Inferred from direct assay	19781630	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	20700442	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11956154	MGI
enables protein kinase binding	IPI IPI: Inferred from physical interaction	21307259	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in clathrin coat assembly involved in endocytosis	IMP IMP: Inferred from mutant phenotype	35220002	MGI
involved in modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	24643165	MGI
involved in modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	24643165	MGI
involved in regulation of vesicle size	IMP IMP: Inferred from mutant phenotype	35220002	MGI
involved in synaptic vesicle endocytosis	IDA IDA: Inferred from direct assay	17463283	MGI
involved in synaptic vesicle endocytosis	IMP IMP: Inferred from mutant phenotype	17463283	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	24643165	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	24643165	MGI
part of membrane coat	IDA IDA: Inferred from direct assay	11879655	MGI
located in photoreceptor inner segment	IDA IDA: Inferred from direct assay	23746204	MGI
is active in photoreceptor ribbon synapse	IDA IDA: Inferred from direct assay	23785143	MGI
is active in presynaptic endocytic zone membrane	IDA IDA: Inferred from direct assay	23785143	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

dynamin-1

Dnm1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Dnm1	P39053	LRRK2	Homo sapiens	Q5S007	Anti Tag CoIP	24282027
Intra	Dnm1	P39053	Amph	Mus musculus	Q7TQF7	Confocal	23640057
Intra	Dnm1	P39053	Amph	Mus musculus	Q7TQF7	Anti Bait CoIP	23640057

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03903	DNM1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS03904	DNM1L Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dnm1	NCBI	NCBI:1759

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