UBLCP1 - ubiquitin like domain containing CTD phosphatase 1 Gene

Homo sapiens

Also known as CPUB1

Gene ID: 134510 | Gene type: protein coding

About UBLCP1

Cytogenetic location: 5q33.3 Genomic coordinates (GRCh38): 5:159,263,290-159,286,036 (from NCBI)

This gene has 3 transcripts (splice variants) and 212 orthologues. Ubiquitous expression in testis (RPKM 19.2), brain (RPKM 17.4) and 25 other tissues.

Summary

Enables protein serine/threonine Phosphatase activity. Involved in protein dephosphorylation. Located in nucleolus and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

UBLCP1 Products(1)

mRNA	Protein	Name
NM_145049.5	NP_659486.2	ubiquitin-like domain-containing CTD phosphatase 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables proteasome regulatory particle binding	IPI IPI: Inferred from physical interaction	28539385	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables protein serine/threonine phosphatase activity	IDA IDA: Inferred from direct assay	21949367	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of ATP-dependent activity	IDA IDA: Inferred from direct assay	28539385	GOA
involved in regulation of proteasome assembly	IMP IMP: Inferred from mutant phenotype	28539385	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	21949367	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UBLCP1 Protein Structure

ubiquitin

NIF

0
100
200
300
318 a.a.

Protein Preferred Names

Protein Names

ubiquitin-like domain-containing CTD phosphatase 1

CTD phosphatase-like with ubiquitin domain 1

UBLCP1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	UBLCP1	Q8WVY7	PSMD2	Homo sapiens	Q13200	Anti Tag CoIP	27880917
Intra	UBLCP1	Q8WVY7	PSMD2	Homo sapiens	Q13200	Y2H Prey Pooling	25416956
Intra	UBLCP1	Q8WVY7	PSMD2	Homo sapiens	Q13200	Y2H Prey Pooling	32296183
Intra	UBLCP1	Q8WVY7	PSMD2	Homo sapiens	Q13200	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15378	UBLCP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	UBLCP1	VGNC	VGNC:36609
Mus musculus	UBLCP1	MGD	MGI:1933105
Rattus norvegicus	UBLCP1	RGD	RGD:1310386
Macaca mulatta	UBLCP1	VGNC	VGNC:79684
Canis familiaris	UBLCP1	VGNC	VGNC:48080
Felis catus	UBLCP1	VGNC	VGNC:66777

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