1. Gene
  2. PSMD2 - proteasome 26S subunit ubiquitin receptor, non-ATPase 2 Gene

PSMD2 - proteasome 26S subunit ubiquitin receptor, non-ATPase 2 Gene

Homo sapiens

Also known as S2; P97; RPN1; TRAP2

Gene ID: 5708 | Gene type: protein coding

About PSMD2

Cytogenetic location: 3q27.1 Genomic coordinates (GRCh38): 3:184,299,241-184,309,050 (from NCBI)

This gene has 20 transcripts (splice variants), 217 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 64.5), brain (RPKM 40.8) and 25 other tissues.

Summary

The 26S Proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave Peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified Proteasome, the immunoproteasome, is the processing of class I MHC Peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. In addition to participation in Proteasome function, this subunit may also participate in the TNF signalling pathway since it interacts with the tumor necrosis factor type 1 receptor. A pseudogene has been identified on chromosome 1. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

PSMD2 Products(3)

mRNA Protein Name
NM_001278708.2 NP_001265637.1 26S proteasome non-ATPase regulatory subunit 2 isoform 2
NM_001278709.2 NP_001265638.1 26S proteasome non-ATPase regulatory subunit 2 isoform 3
NM_002808.5 NP_002799.3 26S proteasome non-ATPase regulatory subunit 2 isoform 1
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
11278995 GOA
Cellular Component GO Annotation Evidence Reference Source
part of proteasome complex IDA
IDA: Inferred from direct assay
17323924 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PSMD2 Protein Structure

PC_rep

PC_rep: Proteasome/cyclosome repeat (443 - 478)

PC_rep

PC_rep: Proteasome/cyclosome repeat (480 - 512)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 908 a.a.
Protein Preferred Names Protein Names

26S proteasome non-ATPase regulatory subunit 2

55.11 protein

PSMD2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra PSMD2 Q13200 PSMC1 Homo sapiens Q53XL8
Y2H Prey Pooling
25416956
Intra PSMD2 Q13200 PSMC1 Homo sapiens Q53XL8
Validated Y2H
25416956
Intra PSMD2 Q13200 BAG1 Homo sapiens Q99933
Validated Y2H
32296183
Intra PSMD2 Q13200 BAG1 Homo sapiens Q99933
Lumier
25036637
Intra PSMD2 Q13200 BAG1 Homo sapiens Q99933
Validated Y2H
25416956
Intra PSMD2 Q13200 BAG1 Homo sapiens Q99933
Y2H Prey Pooling
32296183
Intra PSMD2 Q13200 UCHL5 Homo sapiens Q9Y5K5
Anti Tag CoIP
35271311
Intra PSMD2 Q13200 NEK7 Homo sapiens Q8TDX7
Validated Y2H
32814053
Intra PSMD2 Q13200 NEK7 Homo sapiens Q8TDX7
Y2H Pooling
32814053
Intra PSMD2 Q13200 NEK7 Homo sapiens Q8TDX7
Y2H Array
32814053
Intra PSMD2 Q13200 TBC1D3G Homo sapiens Q6DHY5
Y2H Prey Pooling
32296183
Intra PSMD2 Q13200 TBC1D3G Homo sapiens Q6DHY5
Validated Y2H
32296183
Intra PSMD2 Q13200 TBC1D3G Homo sapiens Q6DHY5
Y2H Array
32296183
Intra PSMD2 Q13200 TGFBR2 Homo sapiens P37173
Y2H Pooling
32814053
Intra PSMD2 Q13200 TGFBR2 Homo sapiens P37173
Validated Y2H
32814053
Intra PSMD2 Q13200 TGFBR2 Homo sapiens P37173
Y2H Array
32814053
Intra PSMD2 Q13200 SERPINH1 Homo sapiens P50454
Validated Y2H
32814053
Intra PSMD2 Q13200 SERPINH1 Homo sapiens P50454
Y2H Array
32814053
Intra PSMD2 Q13200 SERPINH1 Homo sapiens P50454
Y2H Pooling
32814053
Intra PSMD2 Q13200 PSMC1 Homo sapiens P62191
Y2H Pooling
19060904
Intra PSMD2 Q13200 PSMC1 Homo sapiens P62191
Y2H Prey Pooling
25416956
Intra PSMD2 Q13200 PSMC1 Homo sapiens P62191
Anti Tag CoIP
19490896
Intra PSMD2 Q13200 PSMC1 Homo sapiens P62191
Y2H Array
19060904
Intra PSMD2 Q13200 PSMC1 Homo sapiens P62191
Anti Tag CoIP
35271311
Intra PSMD2 Q13200 PSMC1 Homo sapiens P62191
Y2H Array
25416956
Intra PSMD2 Q13200 PSMD3 Homo sapiens O43242
Lumier
25036637
Intra PSMD2 Q13200 PSMD3 Homo sapiens O43242
Anti Tag CoIP
33961781
Intra PSMD2 Q13200 PSMD3 Homo sapiens O43242
Anti Tag CoIP
35271311
Intra PSMD2 Q13200 PSMC5 Homo sapiens P62195
Anti Tag CoIP
35271311
Intra PSMD2 Q13200 PSMD4 Homo sapiens P55036
Lumier
25036637
Intra PSMD2 Q13200 PSMD4 Homo sapiens P55036
Anti Tag CoIP
35271311
Intra PSMD2 Q13200 PSMC2 Homo sapiens P35998
Y2H Array
32296183
Intra PSMD2 Q13200 PSMC2 Homo sapiens P35998
Anti Tag CoIP
35271311
Intra PSMD2 Q13200 PSMC2 Homo sapiens P35998
Y2H Prey Pooling
32296183
Intra PSMD2 Q13200 PRKACA Homo sapiens P17612
Y2H Array
32814053
Intra PSMD2 Q13200 PRKACA Homo sapiens P17612
Validated Y2H
32814053
Intra PSMD2 Q13200 PRKACA Homo sapiens P17612
Y2H Pooling
32814053
Intra PSMD2 Q13200 MLF1 Homo sapiens P58340
Lumier
25036637
Intra PSMD2 Q13200 RAD23A Homo sapiens P54725
Validated Y2H
32814053
Intra PSMD2 Q13200 RAD23A Homo sapiens P54725
Y2H Pooling
32814053
Intra PSMD2 Q13200 RAD23A Homo sapiens P54725
Y2H Array
32814053
Intra PSMD2 Q13200 UBLCP1 Homo sapiens Q8WVY7
Y2H Prey Pooling
25416956
Intra PSMD2 Q13200 UBLCP1 Homo sapiens Q8WVY7
Validated Y2H
32296183
Intra PSMD2 Q13200 UBLCP1 Homo sapiens Q8WVY7
Validated Y2H
25416956
Intra PSMD2 Q13200 UBLCP1 Homo sapiens Q8WVY7
Y2H Prey Pooling
32296183
Intra PSMD2 Q13200 UBLCP1 Homo sapiens Q8WVY7
Y2H Array
25416956
Intra PSMD2 Q13200 UBLCP1 Homo sapiens Q8WVY7
Y2H Pooling
16189514
Intra PSMD2 Q13200 UBLCP1 Homo sapiens Q8WVY7
Y2H Array
32296183
Intra PSMD2 Q13200 UBLCP1 Homo sapiens Q8WVY7
Anti Tag CoIP
33961781
Cross PSMD2 Q13200 Hacd3 Mus musculus Q8K2C9
Lumier
25036637
Intra PSMD2 Q13200 VPS9D1 Homo sapiens Q9Y2B5
Validated Y2H
32296183
Intra PSMD2 Q13200 VPS9D1 Homo sapiens Q9Y2B5
Y2H Prey Pooling
32296183
Intra PSMD2 Q13200 VPS9D1 Homo sapiens Q9Y2B5
Y2H Array
32296183
Intra PSMD2 Q13200 q53hb3_human Homo sapiens Q53HB3
Lumier
25036637
Intra PSMD2 Q13200 UBQLN2 Homo sapiens Q9UHD9
Validated Y2H
32296183
Intra PSMD2 Q13200 ADRM1 Homo sapiens Q16186
Imaging
16990800
Intra PSMD2 Q13200 ZBTB39 Homo sapiens O15060
Y2H Prey Pooling
32296183
Intra PSMD2 Q13200 ZBTB39 Homo sapiens O15060
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Joubert Syndrome 7

JBTS7

Cerebello-Oculo-Renal Syndrome 3

Cors3

Joubert Syndrome, Type 7

Cystic Fibrosis

Mucoviscidosis

CF

Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

Cystic Fibrosis Lung Disease, Modifier Of

Cystic Fibrosis Of Pancreas

Fibrocystic Disease Of Pancreas

Cf - [Cystic Fibrosis]

Cystic Fibrosis Nos

Fibrocystic Disease

Fibrocystic Disease Of The Pancreas

Mucoviscidosis Of Pancreas

Nonproliferative Fibrocystic Disease

Pancreatic Cystic Fibrosis

Invasive Bladder Transitional Cell Carcinoma

Invasive Bladder Urothelial Carcinoma

Infiltrating Bladder Urothelial Carcinoma

Joubert Syndrome 1

Joubert Syndrome

Jbts

Cerebellooculorenal Syndrome 1

JBTS1

Joubert-Boltshauser Syndrome

Cerebelloparenchymal Disorder Iv

Cpd4

Cors1

Joubert Syndrome And Related Disorders

Jsrd

Familial Aplasia Of The Vermis

Joubert Syndrome Related Disorders

Js

Cerebellar Vermis Agenesis

Cerebelloparenchymal Disorder 4

Agenesis Of Cerebellar Vermis

Cerebello-Oculo-Renal Syndrome

Cors

Joubert-Bolthauser Syndrome

Cpd Iv

Classic Joubert Syndrome

Joubert Syndrome Type A

Pure Joubert Syndrome

Cerebello-Oculo-Renal Syndrome 1

Joubert Syndrome-1

Joubert Syndrome, Type 1

Joubert'S Syndrome

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Felis catus PSMD2 VGNC VGNC:69122
Mus musculus PSMD2 MGD MGI:1096584
Macaca mulatta PSMD2 VGNC VGNC:84144
Bos taurus PSMD2 VGNC VGNC:33466
Rattus norvegicus PSMD2 RGD RGD:1305752
Canis familiaris PSMD2 VGNC VGNC:45111