COX7C - cytochrome c oxidase subunit 7C Gene

Homo sapiens

Gene ID: 1350 | Gene type: protein coding

About COX7C

Cytogenetic location: 5q14.3 Genomic coordinates (GRCh38): 5:86,617,941-86,620,962 (from NCBI)

This gene has 7 transcripts (splice variants) and 306 orthologues. Ubiquitous expression in kidney (RPKM 507.5), heart (RPKM 430.4) and 25 other tissues.

Summary

Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes subunit VIIc, which shares 87% and 85% amino acid sequence identity with mouse and bovine COX VIIc, respectively, and is found in all tissues. A pseudogene COX7CP1 has been found on chromosome 13. [provided by RefSeq, Jul 2008]

COX7C Products(1)

mRNA	Protein	Name
NM_001867.3	NP_001858.1	cytochrome c oxidase subunit 7C, mitochondrial precursor

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	31536960	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrial membrane	IDA IDA: Inferred from direct assay	30030519	GOA
part of respiratory chain complex IV	IDA IDA: Inferred from direct assay	31536960	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

COX7C Protein Structure

COX7C

0
63 a.a.

Protein Preferred Names

Protein Names

cytochrome c oxidase subunit 7C, mitochondrial

cytochrome c oxidase polypeptide VIIc

COX7C Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	COX7C	P15954	MAGEA2	Homo sapiens	P43356	Y2H Prey Pooling	32296183
Intra	COX7C	P15954	MAGEA2	Homo sapiens	P43356	Validated Y2H	32296183
Intra	COX7C	P15954	MAGEA2	Homo sapiens	P43356	Y2H Array	32296183
Intra	COX7C	P15954	CIDEB	Homo sapiens	Q9UHD4	Y2H Prey Pooling	32296183
Intra	COX7C	P15954	CIDEB	Homo sapiens	Q9UHD4	Y2H Array	32296183
Intra	COX7C	P15954	CIDEB	Homo sapiens	Q9UHD4	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Mitochondrial Complex Iv Deficiency, Nuclear Type 1

Cytochrome C Oxidase Deficiency	Mitochondrial Complex Iv Deficiency
Cox Deficiency	Cytochrome-C Oxidase Deficiency Disease
MC1DN4	Cytochrome-C Oxidase Deficiency
MC4DN1	Mitochondrial Complex I Deficiency, Nuclear Type 4
Complex 4 Mitochondrial Respiratory Chain Deficiency	Complex Iv Deficiency
Mitochondrial Complex 1 Deficiency, Nuclear Type 4	Nuclear Type Mitochondrial Complex I Deficiency 4
Deficiency Of Mitochondrial Respiratory Chain Complex4	MT-C4D
Complex Iv Mitochondrial Respiratory Chain Deficiency	Lethal Neonatal Cardiomyopathy Hypertrophic Due To Cytochrome C Oxidase Deficiency
Mitochondrial Complex Iv Deficiency, Nuclear, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03077	COX7C Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	COX7C	RGD	RGD:2300145
Mus musculus	COX7C	MGD	MGI:103226
Macaca mulatta	COX7C	VGNC	VGNC:110473

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