1. Gene
  2. PACRG - parkin coregulated Gene

PACRG - parkin coregulated Gene

Homo sapiens

Also known as GLUP; PACRG2.1; PARK2CRG; HAK005771

Gene ID: 135138 | Gene type: protein coding

About PACRG

Cytogenetic location: 6q26 Genomic coordinates (GRCh38): 6:162,727,132-163,315,500 (from NCBI)

This gene has 10 transcripts (splice variants), 207 orthologues and 1 paralogue. Low expression observed in reference dataset.

Summary

This gene encodes a protein that is conserved across metazoans. In vertebrates, this gene is linked in a head-to-head arrangement with the adjacent parkin gene, which is associated with autosomal recessive juvenile Parkinson's disease. These genes are co-regulated in various tissues and they share a bi-directional promoter. Both genes are associated with susceptibility to leprosy. The parkin co-regulated gene protein forms a large molecular complex with chaperones, including heat shock proteins 70 and 90, and chaperonin components. This protein is also a component of Lewy bodies in Parkinson's disease patients, and it suppresses unfolded Pael receptor-induced neuronal cell death. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

PACRG Products(3)

mRNA Protein Name
NM_001080378.2 NP_001073847.1 parkin coregulated gene protein isoform 2
NM_001080379.2 NP_001073848.1 parkin coregulated gene protein isoform 2
NM_152410.3 NP_689623.2 parkin coregulated gene protein isoform 1
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables G protein-coupled receptor binding IPI
IPI: Inferred from physical interaction
14532270 GOA
enables Hsp70 protein binding IDA
IDA: Inferred from direct assay
14532270 GOA
enables Hsp90 protein binding IDA
IDA: Inferred from direct assay
14532270 GOA
enables actin binding IDA
IDA: Inferred from direct assay
14532270 GOA
enables alpha-tubulin binding IDA
IDA: Inferred from direct assay
14532270 GOA
enables beta-tubulin binding IDA
IDA: Inferred from direct assay
14532270 GOA
enables heat shock protein binding IPI
IPI: Inferred from physical interaction
14532270 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables protein-folding chaperone binding IPI
IPI: Inferred from physical interaction
14532270 GOA
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
14532270 GOA
Cellular Component GO Annotation Evidence Reference Source
located in axonemal microtubule IDA
IDA: Inferred from direct assay
36191189 GOA
located in cytosol IDA
IDA: Inferred from direct assay
14532270 GOA
located in neuron projection IDA
IDA: Inferred from direct assay
14532270 GOA
located in vesicle IDA
IDA: Inferred from direct assay
14532270 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PACRG Protein Structure

ParcG

ParcG: Parkin co-regulated protein (70 - 205)

ParcG

ParcG: Parkin co-regulated protein (240 - 292)

  • 0
  • 100
  • 200
  • 296 a.a.
Protein Preferred Names Protein Names

parkin coregulated gene protein

PARK2 co-regulated

PACRG Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
PACRG Q96M98 KLHL36 Homo sapiens Q8N4N3
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Parkinson Disease 2, Autosomal Recessive Juvenile

Young-Onset Parkinson Disease

PARK2

Pdj

Autosomal Recessive Juvenile Parkinson Disease 2

Epdf

Parkinson Disease, Juvenile, Type 2

Parkinson'S Disease 2

Autosomal Recessive Juvenile Parkinson Disease

Early-Onset Parkinson Disease

Parkinson Disease 2

Parkinson Disease, Juvenile, Autosomal Recessive

Parkinsonism, Early-Onset, With Diurnal Fluctuation

Autosomal Recessive Juvenile Parkinson'S Disease 2

Jp

Juvenile Parkinsonism

Parkinson Disease Autosomal Recessive, Early Onset

Parkinsonism, Early Onset, With Diurnal Fluctuation

Yopd

Autosomal Recessive Early-Onset Parkinson Disease Type 2

Chromosome 6-Linked Autosomal Recessive Parkinsonism

Early-Onset Parkinsonism With Diurnal Fluctuation

Parkinsonism Young Adult Onset

Parkinson Disease, Type 2

Parkinsonism, Juvenile

Parkin Type Of Early-Onset Parkinson Disease

Park-Parkin

Prkn Parkinson Disease

Parkinsonism

Parkinsonism-Plus

Idiopathic Parkinsonism

Primary Parkinsonism

Paralysis Agitans Syndrome

Parkinsonian Syndrome

Trembling Paralysis

Paralysis Agitans

Shaking Palsy

Shaking Paralysis

Leprosy 3

Leprosy

Leprosy, Susceptibility To, 3

Hansen'S Disease

Leprosy, Susceptibility To

Hansen Disease

Infection Due To Mycobacterium Leprae

LPRS3

Leprosy, Type 3

Anaesthesia Leprosy

Anaesthetic Leprosy

Maculoanaesthetic Leprosy

Macular Leprosy

Leprosy Unspecified

Dermatitis, Atopic, 3

ATOD3

Dermatitis, Atopic, Susceptibility To, 3

Atopic Dermatitis 3

Dermatitis, Atopic, With Asthma

Dermatitis, Atopic 3

Atopic Dermatitis With Asthma

Indeterminate Leprosy

Uncharacteristic Leprosy

Tuberculoid Leprosy

Smooth Leprosy

Type T Leprosy

Leprosy Tuberculoid

Leprosy, Tuberculoid

Hydrocephalus

Hydrocephalus, Nonsyndromic, Autosomal Recessive

Hydrocephalus, X-Linked

Hydrocephalus Adverse Event

Hydrocephaly Nos

Paratyphoid Fever

Paratyphoid B Fever

Paratyphoid C Fever

Paratyphoid Fever A

Paratyphoid Fever B

Paratyphoid Fever C

Paratyphoid

Paratyphoid A

Paratyphoid A Fever

Paratyphoid B

Paratyphoid C

Infection Due To Salmonella Paratyphi

Lepromatous Leprosy

Leprosy, Lepromatous

Type L Leprosy

Leprosy Lepromatous

Parkinson Disease, Late-Onset

Parkinson Disease

Parkinson'S Disease

PD

PARK

Parkinson Disease, Susceptibility To

Late Onset Parkinson'S Disease

Late Onset Parkinson Disease

Paralysis Agitans

Primary Parkinsonism

Idiopathic Parkinson Disease

Parkinson'S

Parkinson Disease, Late-Onset, Susceptibility To

Parkinson Disease, Age Of Onset, Modifier

Lewy Body Parkinson Disease

Idiopathic Parkinson'S Disease

Pd - [Parkinson Disease]

Parkinson Disease Nos

Parkinson, Nos

Primary Parkinson Disease

Epilepsy, Myoclonic Juvenile

Juvenile Myoclonic Epilepsy

Janz Syndrome

Jme

Myoclonic Epilepsy, Juvenile, Susceptibility To, 1

EJM

Myoclonic Epilepsy, Juvenile

Petit Mal, Impulsive

Myoclonic Epilepsy, Juvenile 1

Myoclonic Epilepsy, Juvenile, 1

Adolescent Myoclonic Epilepsy

Juvenile Myoclonus Epilepsy

Juvenile Myoclonic Epilepsy 1

EJM1

Petit Mal Impulsive

Susceptibility To Juvenile Myoclonic Epilepsy 1

Myoclonic Epilepsy Juvenile

Epilepsy, Myoclonic, Juvenile

Myoclonic Epilepsy Of Janz

Jme - [Juvenile Myoclonic Epilepsy]

Primary Ciliary Dyskinesia

Immotile Cilia Syndrome

Kartagener Syndrome

Dextrocardia Bronchiectasis And Sinusitis

Pcd

Ciliary Motility Disorders

Ciliary Motility Disorder

Immotile Ciliary Syndrome

Ciliary Dyskinesia Primary

Ics

Polynesian Bronchiectasis

Dextrocardia-Bronchiectasis-Sinusitis Syndrome

Immotile Cilia Syndrome, Kartagener Type

Primary Ciliary Dyskinesia And Situs Inversus

Primary Ciliary Dyskinesia, Kartagener Type

Siewert Syndrome

Dyskinesia, Ciliary, Primary

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Macaca mulatta PACRG VGNC VGNC:75646
Bos taurus PACRG VGNC VGNC:55070
Mus musculus PACRG MGD MGI:1916560
Felis catus PACRG VGNC VGNC:102479
Rattus norvegicus PACRG RGD RGD:1561027