S1pr1 - sphingosine-1-phosphate receptor 1 Gene

Mus musculus

Also known as S1p; Edg1; Lpb1; S1p1

Gene ID: 13609 | Gene type: protein coding

About S1pr1

Chromosome 3: 115,504,082-115,508,721 reverse strand.GRCm39:CM000996.3

This gene has 1 transcript (splice variant), 199 orthologues, 18 paralogues and is associated with 34 phenotypes. Broad expression in lung adult (RPKM 117.9), spleen adult (RPKM 77.3) and 21 other tissues.

Summary

This gene encodes a G-protein-coupled receptor bound by the lysophospholipid, sphingosine 1-phosphate. The gene product functions in endothelial cells and is involved in vascular and heart development. This receptor is highly expressed in T and B lymphocytes, and it plays a role in T cell and B cell export from peripheral lymphoid organs. This protein is bound and downregulated by FTY720, an exogenous immunosuppressant drug studied in mouse disease models for multiple sclerosis in humans. [provided by RefSeq, Jan 2010]

S1pr1 Products(1)

mRNA	Protein	Name
NM_007901.5	NP_031927.2	sphingosine 1-phosphate receptor 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables sphingosine-1-phosphate receptor activity	IMP IMP: Inferred from mutant phenotype	11032855	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in T cell migration	IMP IMP: Inferred from mutant phenotype	14732704	MGI
involved in actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	11726541	MGI
acts upstream of or within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	11443127	MGI
acts upstream of or within angiogenesis	IDA IDA: Inferred from direct assay	15371328	MGI
involved in blood vessel maturation	IMP IMP: Inferred from mutant phenotype	11032855	MGI
acts upstream of or within brain development	IMP IMP: Inferred from mutant phenotype	16314531	MGI
involved in cardiac muscle tissue growth involved in heart morphogenesis	IMP IMP: Inferred from mutant phenotype	21668976	MGI
involved in cell migration	IMP IMP: Inferred from mutant phenotype	19204730	MGI
acts upstream of cell population proliferation	IMP IMP: Inferred from mutant phenotype	16314531	MGI
involved in chemotaxis	IMP IMP: Inferred from mutant phenotype	11032855	MGI
involved in heart trabecula morphogenesis	IMP IMP: Inferred from mutant phenotype	21668976	MGI
involved in lamellipodium assembly	IMP IMP: Inferred from mutant phenotype	11726541	MGI
acts upstream of or within leukocyte chemotaxis	IDA IDA: Inferred from direct assay	25348153	MGI
acts upstream of or within positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	16314531	MGI
involved in regulation of bone mineralization	IMP IMP: Inferred from mutant phenotype	19204730	MGI
involved in regulation of bone resorption	IMP IMP: Inferred from mutant phenotype	19204730	MGI
acts upstream of or within regulation of cell adhesion	IDA IDA: Inferred from direct assay	15371328	MGI
involved in sphingosine-1-phosphate receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	11032855	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in external side of plasma membrane	IMP IMP: Inferred from mutant phenotype	18836449	MGI
is active in presynapse	IDA IDA: Inferred from direct assay	35781853	MGI
is active in presynapse	IEP IEP: Inferred from expression pattern	35781853	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

S1pr1 Protein Structure

7tmA_S1PR1_Edg1

0
100
200
300
382 a.a.

Protein Preferred Names

Protein Names

sphingosine 1-phosphate receptor 1

S1P receptor 1	S1P receptor Edg-1
endothelial differentiation G-protein coupled receptor 1	endothelial differentiation sphingolipid G-protein-coupled receptor 1
lysophospholipid receptor B1	sphingosine 1-phosphate receptor Edg-1

Related Agents

Approval

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12355	Siponimod	Agonist	99.95%	Yes
HY-12288	Ozanimod	Agonist	99.88%	Yes
HY-10569	Ponesimod	Agonist	99.81%	Yes
HY-12288A	Ozanimod hydrochloride	Modulator	99.19%	Yes
HY-12355A	Siponimod hemifumarate	Agonist	/	Unkown

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-17606	Cenerimod	Agonist	99.43%	Phase 3
HY-115831	SAR247799	Agonist	97.21%	Phase 1

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W008947	SEW2871	Agonist	99.77%	Unkown
HY-136578	RP101988	Agonist	98.80%	Unkown
HY-111253	CYM-5478	Agonist	99.90%	Unkown
HY-147660	IMMH001	Agonist	98.10%	Unkown
HY-113934	L-threo Lysosphingomyelin (d18:1)	Agonist	≥98.0%	Unkown
HY-136576	RP101075	Agonist	/	Unkown
HY-158417	KSI-6666	Antagonist	/	Unkown
HY-119245	Udifitimod	Modulator	/	Unkown
HY-136577	RP101442	Agonist	/	Unkown
HY-108492	TC-SP 14	Agonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	S1pr1	NCBI	NCBI:1901

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