MPLKIP - M-phase specific PLK1 interacting protein Gene

Homo sapiens

Also known as ABHS; TTD4; ORF20; C7orf11

Gene ID: 136647 | Gene type: protein coding

About MPLKIP

Cytogenetic location: 7p14.1 Genomic coordinates (GRCh38): 7:40,126,027-40,134,622 (from NCBI)

This gene has 1 transcript (splice variant), 149 orthologues and is associated with 4 phenotypes. Ubiquitous expression in liver (RPKM 18.5), kidney (RPKM 17.4) and 25 other tissues.

Summary

The protein encoded by this gene localizes to the centrosome during mitosis and to the midbody during cytokinesis. The protein is phosphorylated by cyclin-dependent kinase 1 during mitosis and subsequently interacts with polo-like kinase 1. The protein is thought to function in regulating mitosis and cytokinesis. Mutations in this gene result in nonphotosensitive trichothiodystrophy. [provided by RefSeq, Nov 2009]

MPLKIP Products(1)

mRNA	Protein	Name
NM_138701.4	NP_619646.1	M-phase-specific PLK1-interacting protein

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17310276	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in centrosome	IDA IDA: Inferred from direct assay	17310276	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	17310276	GOA
located in midbody	IDA IDA: Inferred from direct assay	17310276	GOA
located in nucleus	IDA IDA: Inferred from direct assay	17310276	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MPLKIP Protein Structure

MPLKIP

0
100
179 a.a.

Protein Preferred Names

Protein Names

M-phase-specific PLK1-interacting protein

Russell-Silver syndrome region

Related Diseases

Diseases

Alias

Trichothiodystrophy 4, Nonphotosensitive

Amish Brittle Hair Brain Syndrome	TTD4
Trichothiodystrophy, Nonphotosensitive 1	Hair-Brain Syndrome
Bids Syndrome	Ttdn1
Abhs	Pollitt Syndrome
Trichothiodystrophy-Neurocutaneous Syndrome	Nonphotosensitive Trichothiodystrophy 4
Trichorrhexis Nodosa Syndrome	Trichothiodystrophy 4, Non-Photosensitive
Trichothiodystrophy Non-Photosensitive 1

Nonphotosensitive Trichothiodystrophy

Trichothiodystrophy Nonphotosensitive

Amish Brittle Hair Brain Syndrome

Trichothiodystrophy 1, Photosensitive

TTD1	Tay Syndrome
Trichothiodystrophy With Congenital Ichthyosis	Photosensitive Trichothiodystrophy
Ibids Syndrome	Ttdp
Ichthyosiform Erythroderma With Hair Abnormality And Mental And Growth Retardation	Ichthyosis, Congenital, With Trichothiodystrophy
Pibids Syndrome	Photosensitive Trichothiodystrophy 1
Trichothiodystrophy, Photosensitive	Sulfur-Deficient Brittle Hair Syndrome
Ttd-P	Ichthyosis With Brittle Hair, Intellectual Impairment, Decreased Fertility And Short Stature
Trichothiodystrophy Photosensitive	Trichothiodystrophy, Type 1
Tricho-Thiodystrophy Disorder	Trichothiodystrophy Syndromes
Amish Brittle Hair Brain Syndrome

Trichothiodystrophy 3, Photosensitive

TTD3	Trichothiodystrophy, Complementation Group A
Ttda	Photosensitive Trichothiodystrophy 3
Trichothiodystrophy Complementation Group A

Trichothiodystrophy

Ttd	Amish Brittle Hair Syndrome
Bids Syndrome	Brittle Hair-Intellectual Impairment-Decreased Fertility-Short Stature Syndrome
Ibids	Pibids
Trichothiodystrophy Syndromes

Glutaric Aciduria Iii

Glutaryl-Coa Oxidase Deficiency	Ga Iii
Glutaric Acidemia Type 3	GA3
Glutaric Aciduria Type 3	Glutaric Aciduria 3
Glutaric Acidemia Type Iii	Glutaric Aciduria Type Iii

Ciliary Dyskinesia, Primary, 6

Primary Ciliary Dyskinesia 6	CILD6
Ics6	Immotile Cilia Syndrome 6
Dyskinesia, Ciliary, Primary, 6

Robinow Syndrome, Autosomal Dominant 3

Autosomal Dominant Robinow Syndrome 3	DRS3
Robinow, Autosomal Dominant Syndrome, Type 3

Ichthyosis

Ichthyoses	Non-Syndromic Ichthyosis
Congenital Ichthyosis

Cerebrooculofacioskeletal Syndrome

Cerebro-Oculo-Facio-Skeletal Syndrome	Cofs Syndrome
Pena-Shokeir Syndrome Type 2	Pena Shokeir Syndrome Type 2

Uv-Sensitive Syndrome

Uvss	Uv Sensitive Syndrome
Ultraviolet Sensitive Syndrome

Xeroderma Pigmentosum, Variant Type

Xeroderma Pigmentosum	XPV
Xeroderma Pigmentosum Variant Type	Xeroderma Pigmentosum With Normal Dna Repair Rates
Photosensitivity With Defective Dna Synthesis	Xp
De Sanctis-Cacchione Syndrome	Desanctis-Cacchione Syndrome
Xeroderma Pigmentosa	Xerodermic Idiocy
Xeroderma Pigmentosum Variant	Xp - [Xeroderma Pigmentosum]
Atrophoderma Pigmentosum

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08619	MPLKIP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	MPLKIP	VGNC	VGNC:31579
Rattus norvegicus	MPLKIP	RGD	RGD:1584365
Mus musculus	MPLKIP	MGD	MGI:1913558
Felis catus	MPLKIP	VGNC	VGNC:80626
Macaca mulatta	MPLKIP	VGNC	VGNC:74773
Canis familiaris	MPLKIP	VGNC	VGNC:43339

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