AKAP8L - A-kinase anchoring protein 8 like Gene

Homo sapiens

Also known as HA95; HAP95; NAKAP; NAKAP95

Gene ID: 26993 | Gene type: protein coding

About AKAP8L

Cytogenetic location: 19p13.12 Genomic coordinates (GRCh38): 19:15,380,050-15,418,988 (from NCBI)

This gene has 39 transcripts (splice variants), 198 orthologues and 2 paralogues. Ubiquitous expression in bone marrow (RPKM 21.2), testis (RPKM 18.0) and 25 other tissues.

Summary

Enables histone deacetylase binding activity and lamin binding activity. Involved in several processes, including mitotic chromosome condensation; regulation of histone modification; and regulation of mRNA export from nucleus. Located in chromatin; cytoplasm; and nuclear lumen. Part of ribonucleoprotein complex. [provided by Alliance of Genome Resources, Apr 2022]

AKAP8L Products(2)

mRNA	Protein	Name
NM_001291478.2	NP_001278407.1	A-kinase anchor protein 8-like isoform 2
NM_014371.4	NP_055186.3	A-kinase anchor protein 8-like isoform 1

AKAP8L Protein Structure

AKAP95

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646 a.a.

Protein Preferred Names

Protein Names

A-kinase anchor protein 8-like

A kinase (PRKA) anchor protein 8-like

Related Diseases

Diseases

Alias

Pelger-Huet Anomaly

PHA	Pelger-Huët Anomaly
Ovoid Neutrophil Nuclei, Developmental Delay, Epilepsy And Skeletal Abnormalities	Pelger Huet Anomaly
Pelger-Huet Nuclear Anomaly

Greenberg Dysplasia

Hem Dysplasia	Greenberg Skeletal Dysplasia
Hem Skeletal Dysplasia	GRBGD
Hydrops-Ectopic Calcification-Moth-Eaten Skeletal Dysplasia	Moth-Eaten Skeletal Dysplasia
Chondrodystrophy, Hydropic And Prenatally Lethal Type	Hydrops-Ectopic Calcification-Motheaten Syndrome
Skeletal Dysplasia, Greenberg Type	Autosomal Recessive Lethal Chondrodystrophy With Congenital Hydrops
Hydrops, Ectopic Calcification, Moth-Eaten Skeletal Dysplasia	Hem
Hem/Greenberg Dysplasia	Hydrops - Ectopic Calcification - Moth-Eaten Skeletal Dysplasia

Cardiomyopathy, Dilated, 1a

Dilated Cardiomyopathy 1a	Cdcd1
CMD1A	Cardiomyopathy, Familial Idiopathic
Familial Dilated Cardiomyopathy With Conduction Defect Due To Lmna Mutation	Cardiomyopathy, Dilated, With Conduction Defect 1
Cardiomyopathy, Idiopathic Dilated	Cardiomyopathy, Congestive
Dilated Cardiomyopathy With Conduction Defect 1	Cardiomyopathy Dilated With Conduction Defect Type 1
Cardiomyopathy, Dilated 1a	Cardiomyopathy Dilated With Conduction Defect 1
Cardiomyopathy, Dilated, Type 1a

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00524	AKAP8L Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	AKAP8L	MGD	MGI:1860606
Macaca mulatta	AKAP8L	VGNC	VGNC:108460
Bos taurus	AKAP8L	VGNC	VGNC:25790
Rattus norvegicus	AKAP8L	RGD	RGD:1359200
Felis catus	AKAP8L	VGNC	VGNC:69344
Canis familiaris	AKAP8L	VGNC	VGNC:37762

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