2. Gene
  3. AKAP8L - A-kinase anchoring protein 8 like Gene

AKAP8L - A-kinase anchoring protein 8 like Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as HA95; HAP95; NAKAP; NAKAP95

Gene ID: 26993 | Gene type: protein coding

About AKAP8L

Cytogenetic location: 19p13.12 Genomic coordinates (GRCh38): 19:15,380,050-15,418,988 (from NCBI)

This gene has 39 transcripts (splice variants), 198 orthologues and 2 paralogues. Ubiquitous expression in bone marrow (RPKM 21.2), testis (RPKM 18.0) and 25 other tissues.

Summary

Enables histone deacetylase binding activity and lamin binding activity. Involved in several processes, including mitotic chromosome condensation; regulation of histone modification; and regulation of mRNA export from nucleus. Located in chromatin; cytoplasm; and nuclear lumen. Part of ribonucleoprotein complex. [provided by Alliance of Genome Resources, Apr 2022]

AKAP8L Products(2)

mRNA Protein Name
NM_001291478.2 NP_001278407.1 A-kinase anchor protein 8-like isoform 2
NM_014371.4 NP_055186.3 A-kinase anchor protein 8-like isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables histone deacetylase binding IDA
IDA: Inferred from direct assay
16980585 GOA
enables lamin binding IDA
IDA: Inferred from direct assay
11034899 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11402034 GOA
Biological Process GO Annotation Evidence Reference Source
involved in cell cycle G2/M phase transition IMP
IMP: Inferred from mutant phenotype
16980585 GOA
involved in mRNA processing IDA
IDA: Inferred from direct assay
17594903 GOA
involved in mitotic chromosome condensation IMP
IMP: Inferred from mutant phenotype
11034899 GOA
involved in nuclear membrane disassembly IMP
IMP: Inferred from mutant phenotype
11034899 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
11884601 GOA
involved in regulation of mRNA export from nucleus IDA
IDA: Inferred from direct assay
11402034 GOA
Cellular Component GO Annotation Evidence Reference Source
located in chromatin IDA
IDA: Inferred from direct assay
11034899 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
11402034 GOA
located in nuclear matrix IDA
IDA: Inferred from direct assay
11034899 GOA
located in nuclear speck IDA
IDA: Inferred from direct assay
17594903 GOA
located in nucleus IDA
IDA: Inferred from direct assay
11402034 GOA
part of ribonucleoprotein complex IDA
IDA: Inferred from direct assay
11402034 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AKAP8L Protein Structure

AKAP95

AKAP95: A-kinase anchoring protein 95 (AKAP95) (389 - 554)

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  • 646 a.a.
Protein Preferred Names Protein Names

A-kinase anchor protein 8-like

A kinase (PRKA) anchor protein 8-like

AKAP8L Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
AKAP8L Q9ULX6 PCDHB14 Homo sapiens Q9Y5E9
Validated Y2H
32296183
Intra
AKAP8L Q9ULX6 HEMK1 Homo sapiens Q9Y5R4
Validated Y2H
32296183
Intra
AKAP8L Q9ULX6 SAMD4A Homo sapiens Q9UPU9-3
Validated Y2H
32296183
Intra
AKAP8L Q9ULX6 HDAC3 Homo sapiens O15379
Anti Bait CoIP
16980585
Cross
AKAP8L Q9ULX6 Prpf40a Mus musculus Q9R1C7
Far-WB
16391387
Cross
AKAP8L Q9ULX6 Prpf40a Mus musculus Q9R1C7
Y2H
16391387
Intra
AKAP8L Q9ULX6 PTEN Homo sapiens P60484
Anti Bait CoIP
36950384
Intra
AKAP8L Q9ULX6 CARHSP1 Homo sapiens Q9Y2V2
Validated Y2H
32296183
Cross
AKAP8L Q9ULX6 P29991-PRO_0000308465 Dengue virus type 2 P29991-PRO_0000308465
Y2H
21911577
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Pelger-Huet Anomaly

PHA

Pelger-Huët Anomaly

Ovoid Neutrophil Nuclei, Developmental Delay, Epilepsy And Skeletal Abnormalities

Pelger Huet Anomaly

Pelger-Huet Nuclear Anomaly
Greenberg Dysplasia

Hem Dysplasia

Greenberg Skeletal Dysplasia

Hem Skeletal Dysplasia

GRBGD

Hydrops-Ectopic Calcification-Moth-Eaten Skeletal Dysplasia

Moth-Eaten Skeletal Dysplasia

Chondrodystrophy, Hydropic And Prenatally Lethal Type

Hydrops-Ectopic Calcification-Motheaten Syndrome

Skeletal Dysplasia, Greenberg Type

Autosomal Recessive Lethal Chondrodystrophy With Congenital Hydrops

Hydrops, Ectopic Calcification, Moth-Eaten Skeletal Dysplasia

Hem

Hem/Greenberg Dysplasia

Hydrops - Ectopic Calcification - Moth-Eaten Skeletal Dysplasia
Cardiomyopathy, Dilated, 1a

Dilated Cardiomyopathy 1a

Cdcd1

CMD1A

Cardiomyopathy, Familial Idiopathic

Familial Dilated Cardiomyopathy With Conduction Defect Due To Lmna Mutation

Cardiomyopathy, Dilated, With Conduction Defect 1

Cardiomyopathy, Idiopathic Dilated

Cardiomyopathy, Congestive

Dilated Cardiomyopathy With Conduction Defect 1

Cardiomyopathy Dilated With Conduction Defect Type 1

Cardiomyopathy, Dilated 1a

Cardiomyopathy Dilated With Conduction Defect 1

Cardiomyopathy, Dilated, Type 1a
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00524 AKAP8L Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus AKAP8L MGD MGI:1860606
Macaca mulatta AKAP8L VGNC VGNC:108460
Bos taurus AKAP8L VGNC VGNC:25790
Rattus norvegicus AKAP8L RGD RGD:1359200
Felis catus AKAP8L VGNC VGNC:69344
Canis familiaris AKAP8L VGNC VGNC:37762