PTRH1 - peptidyl-tRNA hydrolase 1 homolog Gene

Homo sapiens

Also known as PTH1; C9orf115

Gene ID: 138428 | Gene type: protein coding

About PTRH1

This gene has 9 transcripts (splice variants) and 182 orthologues. Broad expression in kidney (RPKM 2.9), testis (RPKM 2.7) and 25 other tissues.

Summary

Enables RNA binding activity. [provided by Alliance of Genome Resources, Apr 2022]

PTRH1 Products(5)

mRNA	Protein	Name
NM_001002913.3	NP_001002913.1	probable peptidyl-tRNA hydrolase isoform 1
NM_001345977.1	NP_001332906.1	probable peptidyl-tRNA hydrolase isoform 2
NM_001345978.1	NP_001332907.1	probable peptidyl-tRNA hydrolase isoform 3
NM_001345979.1	NP_001332908.1	probable peptidyl-tRNA hydrolase isoform 4
NM_001345980.1	NP_001332909.1	probable peptidyl-tRNA hydrolase isoform 5

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables aminoacyl-tRNA hydrolase activity	IDA IDA: Inferred from direct assay	30244831	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in rescue of stalled ribosome	IDA IDA: Inferred from direct assay	30244831	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTRH1 Protein Structure

Pept_tRNA_hydro

0
100
200
214 a.a.

Protein Preferred Names

Protein Names

probable peptidyl-tRNA hydrolase

PTH

PTRH1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PTRH1	Q86Y79	FAM9B	Homo sapiens	Q8IZU0	Y2H Array	25416956
Intra	PTRH1	Q86Y79	LCN2	Homo sapiens	P80188	Y2H Prey Pooling	32296183
Intra	PTRH1	Q86Y79	LCN2	Homo sapiens	P80188	Y2H Array	32296183
Intra	PTRH1	Q86Y79	ANKRD28	Homo sapiens	O15084	Y2H Array	32296183
Intra	PTRH1	Q86Y79	ANKRD28	Homo sapiens	O15084	Y2H Prey Pooling	32296183
Intra	PTRH1	Q86Y79	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
Intra	PTRH1	Q86Y79	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183
Intra	PTRH1	Q86Y79	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Vascular Skin Disease

Skin Diseases, Vascular

Skin Vascular Disease

Pancreatic Adenosquamous Carcinoma

Adenosquamous Carcinoma Of Pancreas

Adenosquamous Carcinoma Of The Pancreas

Non-Syndromic X-Linked Intellectual Disability

X-Linked Non-Syndromic Intellectual Disability	Non-Specific X-Linked Mental Retardation
X-Linked Non-Specific Intellectual Disability

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11453	PTRH1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PTRH1	VGNC	VGNC:64432
Mus musculus	PTRH1	MGD	MGI:1913779
Bos taurus	PTRH1	VGNC	VGNC:33561
Canis familiaris	PTRH1	VGNC	VGNC:45201
Macaca mulatta	PTRH1	VGNC	VGNC:76549
Rattus norvegicus	PTRH1	RGD	RGD:1310165

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