Ereg - epiregulin Gene

Mus musculus

Also known as EPR

Gene ID: 13874 | Gene type: protein coding

About Ereg

Summary

Enables epidermal growth factor receptor binding activity. Involved in several processes, including epidermal growth factor receptor signaling pathway; positive regulation of macromolecule metabolic process; and positive regulation of mitotic nuclear division. Located in extracellular space. Is expressed in several structures, including brain; extraembryonic component; lung; ovary; and skin. Human ortholog(s) of this gene implicated in extrapulmonary tuberculosis; pulmonary tuberculosis; and tuberculosis. Orthologous to human EREG (Epiregulin). [provided by Alliance of Genome Resources, Apr 2022]

Ereg Products(1)

mRNA	Protein	Name
NM_007950.2	NP_031976.1	proepiregulin preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables epidermal growth factor receptor binding	IDA IDA: Inferred from direct assay	7706296	MGI
enables receptor ligand activity	IDA IDA: Inferred from direct assay	7706296	MGI
enables receptor ligand activity	IGI IGI: Inferred from genetic interaction	28783046	MGI
enables transmembrane receptor protein tyrosine kinase activator activity	IDA IDA: Inferred from direct assay	7706296	MGI
enables transmembrane receptor protein tyrosine kinase activator activity	IGI IGI: Inferred from genetic interaction	28783046	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in epidermal growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	7706296	MGI
involved in epidermal growth factor receptor signaling pathway	IGI IGI: Inferred from genetic interaction	28783046	MGI
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	7706296	MGI
involved in positive regulation of DNA replication	IDA IDA: Inferred from direct assay	7706296	MGI
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	7706296	MGI
involved in positive regulation of cytokine production	IMP IMP: Inferred from mutant phenotype	16182244	MGI
involved in positive regulation of innate immune response	IMP IMP: Inferred from mutant phenotype	16182244	MGI
involved in positive regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	16182244	MGI
involved in positive regulation of mitotic nuclear division	IDA IDA: Inferred from direct assay	7706296	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	9337852	MGI
is active in extracellular space	IGI IGI: Inferred from genetic interaction	28783046	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

proepiregulin

Recombinant Ereg Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75226	Epiregulin Protein, Mouse (HEK293, hFc)	Q61521 (V56-L101)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04487	EREG Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ereg	NCBI	NCBI:2069

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