EREG - epiregulin Gene

Homo sapiens

Also known as ER; Ep; EPR

Gene ID: 2069 | Gene type: protein coding

About EREG

Cytogenetic location: 4q13.3 Genomic coordinates (GRCh38): 4:74,365,145-74,388,749 (from NCBI)

This gene has 3 transcripts (splice variants), 138 orthologues and 5 paralogues. Biased expression in bone marrow (RPKM 51.6), esophagus (RPKM 7.6) and 3 other tissues.

Summary

This gene encodes a secreted peptide hormone and member of the epidermal growth factor (EGF) family of proteins. The encoded protein is a ligand of the epidermal growth factor receptor (EGFR) and the structurally related erb-b2 receptor tyrosine kinase 4 (ERBB4). The encoded protein may be involved in a wide range of biological processes including inflammation, wound healing, oocyte maturation, and cell proliferation. Additionally, the encoded protein may promote the progression of cancers of various human tissues. [provided by RefSeq, Jul 2015]

EREG Products(1)

mRNA	Protein	Name
NM_001432.3	NP_001423.1	proepiregulin preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	9419975	GOA
enables receptor ligand activity	IDA IDA: Inferred from direct assay	9556621	GOA
enables transmembrane receptor protein tyrosine kinase activator activity	IDA IDA: Inferred from direct assay	9556621	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in ERBB2-EGFR signaling pathway	IDA IDA: Inferred from direct assay	9556621	GOA
involved in ERBB2-ERBB4 signaling pathway	IDA IDA: Inferred from direct assay	9556621	GOA
involved in ERBB4-ERBB4 signaling pathway	IDA IDA: Inferred from direct assay	9556621	GOA
involved in cell-cell signaling	IDA IDA: Inferred from direct assay	14581411	GOA
involved in cytokine-mediated signaling pathway	IDA IDA: Inferred from direct assay	9419975	GOA
involved in epidermal growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	9556621	GOA
involved in keratinocyte proliferation	IDA IDA: Inferred from direct assay	10681561	GOA
involved in mRNA transcription	IDA IDA: Inferred from direct assay	10681561	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	14581411	GOA
involved in negative regulation of smooth muscle cell differentiation	IDA IDA: Inferred from direct assay	14581411	GOA
involved in positive regulation of DNA replication	IDA IDA: Inferred from direct assay	9337852	GOA
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	10681561	GOA
involved in positive regulation of cytokine production	IDA IDA: Inferred from direct assay	10681561	GOA
involved in positive regulation of fibroblast proliferation	IDA IDA: Inferred from direct assay	12702554	GOA
involved in positive regulation of phosphorylation	IDA IDA: Inferred from direct assay	9419975	GOA
involved in positive regulation of protein kinase activity	IDA IDA: Inferred from direct assay	14581411	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in extracellular space	IDA IDA: Inferred from direct assay	9556621	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	9337852	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

proepiregulin

EREG Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	EREG	O14944	NINJ2	Homo sapiens	Q9NZG7	Validated Y2H	32296183
Intra	EREG	O14944	MS4A13	Homo sapiens	Q5J8X5	Validated Y2H	32296183
Intra	EREG	O14944	OLFM4	Homo sapiens	Q6UX06	Validated Y2H	32296183
Intra	EREG	O14944	EGFR	Homo sapiens	P00533	SAXS	28988771
Intra	EREG	O14944	CXCL9	Homo sapiens	Q07325	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant EREG Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7011	Epiregulin Protein, Human	O14944 (V60-L108)	≥95%
HY-P73031	Epiregulin Protein, Human (HEK293, Fc)	O14944/NP_001423.1 (V63-L108)	≥95%

Related Diseases

Diseases

Alias

Malignant Fibrous Histiocytoma

Undifferentiated Pleomorphic Sarcoma	Ups
Histiocytoma, Malignant Fibrous	Fibroxanthosarcoma
Mfh	Malignant Fibrohistiocytic Tumors
Histiocytoma, Fibrous, Malignant

Squamous Blepharitis

Vallecula Cancer

Malignant Tumor Of Vallecula

Bronchiectasis 2

Bladder Cancer

Urinary Bladder Cancer	Bladder Carcinoma
Urinary Bladder Carcinoma	Bladder Neoplasm
Bladder Tumor	Cancer, Bladder
Malignant Neoplasm Of Urinary Bladder	Carcinoma Of Bladder
Bladder Cancer, Somatic	Tumor Of The Bladder
Carcinoma Of Urinary Bladder	Bladder Carcinoma Urinary
Cancer Of The Urinary Bladder	Cancer, Urinary Bladder
Malignant Bladder Neoplasm	Malignant Bladder Tumor
Neoplasm Of The Bladder	Neoplasm Of The Urinary Bladder
Tumor Of The Urinary Bladder	Urinary Bladder Neoplasm
BLC	Urothelial Carcinoma Of The Bladder
Bladder Tumors	Urinary Bladder Neoplasms
Bladder Cancer Nos	Vesical Cancer Nos
Malignant Neoplasm Of Bladder, Part Unspecified	Malignant Tumour Of Urinary Bladder
Primary Malignant Neoplasm Of Bladder

Mixed Cell Adenoma

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Pancreatic Cancer

Pancreatic Carcinoma	Carcinoma Of Pancreas
Familial Pancreatic Carcinoma	Pancreatic Neoplasm
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Cancer Of The Pancreas	Pancreatic Carcinoma, Somatic
Pancreatic Cancer, Somatic	Ca Body Of Pancreas
Ca Head Of Pancreas	Ca Tail Of Pancreas
Malignant Neoplasm Of Body Of Pancreas	Malignant Neoplasm Of Head Of Pancreas
Malignant Neoplasm Of Tail Of Pancreas	Pancreas Neoplasm
Exocrine Cancer	Exocrine Pancreas Carcinoma
Hereditary Pancreatic Cancer	Hereditary Pancreatic Carcinoma
PNCA	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04487	EREG Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	EREG	VGNC	VGNC:106572
Felis catus	EREG	VGNC	VGNC:61935
Rattus norvegicus	EREG	RGD	RGD:620299
Mus musculus	EREG	MGD	MGI:107508
Bos taurus	EREG	VGNC	VGNC:28575
Others	EREG	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.