2. Gene
  3. Erf - Ets2 repressor factor Gene

Erf - Ets2 repressor factor Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus
Gene ID: 13875 | Gene type: protein coding

About Erf

Summary

Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Acts upstream of or within chorio-allantoic fusion; ectodermal cell differentiation; and trophoblast giant cell differentiation. Located in nucleus. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; hemolymphoid system gland; and nervous system. Human ortholog(s) of this gene implicated in craniosynostosis. Orthologous to human ERF (ETS2 repressor factor). [provided by Alliance of Genome Resources, Apr 2022]

Erf Products(4)

mRNA Protein Name
NM_001412415.1 NP_001399344.1 ETS domain-containing transcription factor ERF isoform a
NM_001412417.1 NP_001399346.1 ETS domain-containing transcription factor ERF isoform c
NM_001412418.1 NP_001399347.1 ETS domain-containing transcription factor ERF isoform c
NM_010155.4 NP_034285.3 ETS domain-containing transcription factor ERF isoform b
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within chorio-allantoic fusion IMP
IMP: Inferred from mutant phenotype
17502352 MGI
acts upstream of or within ectodermal cell differentiation IMP
IMP: Inferred from mutant phenotype
17502352 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
17502352 MGI
acts upstream of or within trophoblast giant cell differentiation IMP
IMP: Inferred from mutant phenotype
17502352 MGI
Cellular Component GO Annotation Evidence Reference Source
located in nucleus IDA
IDA: Inferred from direct assay
17502352 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ETS domain-containing transcription factor ERF

Est2 repressor factor

Related Agents

Pre-clinical Phase
Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-150090 SRI-41315 Activator 99.68% Unkown
HY-120743 Triplin / Unkown
HY-153176 PAT-IN-1 Inhibitor / Unkown
HY-153177 PAT-IN-2 Inhibitor / Unkown
HY-163938 PROTAC erf3a Degrader-1 / Unkown
HY-163938A PROTAC erf3a Degrader-2 / Unkown
HY-163960 NH2-Ph-NH-cyclohexane-NH-Boc / Unkown
HY-163961A Thalidomide-NH-cyclohexane-NH-Ph-NH2 / Unkown
HY-RS04488 ERF Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Erf NCBI NCBI:2077
Canis familiaris Erf NCBI NCBI:100687937
Macaca fascicularis Erf NCBI NCBI:102115865
Canis lupus familiaris Erf NCBI
Susscrofa domestica Erf NCBI
Leporidae Erf NCBI
Rattus norvegicus Erf NCBI NCBI:292721
Macaca mulatta Erf NCBI NCBI:709170