BEND2 - BEN domain containing 2 Gene

Homo sapiens

Also known as CXorf20

Gene ID: 139105 | Gene type: protein coding

About BEND2

This gene has 2 transcripts (splice variants), 188 orthologues and 2 paralogues. Restricted expression toward testis (RPKM 2.6).

Summary

This gene encodes a protein which has two BEN domains in the C-terminus. These domains are found in proteins which participate in protein and DNA interactions which occur during chromatin restructuring or transcription. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

BEND2 Products(2)

mRNA	Protein	Name
NM_001184767.2	NP_001171696.1	BEN domain-containing protein 2 isoform 2
NM_153346.5	NP_699177.2	BEN domain-containing protein 2 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BEND2 Protein Structure

BEN

0
200
400
600
799 a.a.

Protein Preferred Names

Protein Names

BEN domain-containing protein 2

BEND2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	BEND2	Q8NDZ0	LHX2	Homo sapiens	P50458	Y2H Prey Pooling	32296183
Intra	BEND2	Q8NDZ0	LHX2	Homo sapiens	P50458	Y2H Array	32296183
Intra	BEND2	Q8NDZ0	ANAPC11	Homo sapiens	Q9NYG5-2	Validated Y2H	32296183
Intra	BEND2	Q8NDZ0	ANAPC11	Homo sapiens	Q9NYG5-2	Y2H Prey Pooling	32296183
Intra	BEND2	Q8NDZ0	PRR20D	Homo sapiens	P86480	Y2H Prey Pooling	32296183
Intra	BEND2	Q8NDZ0	PRR20D	Homo sapiens	P86480	Y2H Array	32296183
Intra	BEND2	Q8NDZ0	ZMYM6	Homo sapiens	O95789-4	Y2H Array	32296183
Intra	BEND2	Q8NDZ0	ZMYM6	Homo sapiens	O95789-4	Y2H Prey Pooling	32296183
Intra	BEND2	Q8NDZ0	SF3A2	Homo sapiens	Q15428	Y2H Prey Pooling	32296183
Intra	BEND2	Q8NDZ0	SF3A2	Homo sapiens	Q15428	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Astroblastoma, Mn1-Altered

Cns High-Grade Neuroepithelial Tumors With Mn1 Alteration

Astroblastoma

Cerebral Astroblastoma

Central Nervous System Neuroblastoma

Cns Neuroblastoma With Foxr2 Activation

Central Nervous System Neuroblastoma With Foxr2 Activation	Cns Nb-Foxr2
Cns Neuroblastoma, Foxr2-Activated

Central Nervous System Germ Cell Tumor

Central Nervous System Germ Cell Tumour	Germ Cell Tumor Of The Cns
Germ Cell Tumour Of The Cns

Rela Fusion-Positive Ependymoma

Supratentorial C11orf95-Rela Fused Ependymoma

C11orf95 Fusion-Positive Supratentorial Ependymoma

Tanycytic Ependymoma

Anaplastic Pleomorphic Xanthoastrocytoma

Supratentorial Ependymoma

High Grade Ependymoma

Ependymal Neoplasm	Ependymal Tumors
Malignant Ependymoma	Ependymal Tumor
Anaplastic Ependymoma	Experimental Organism Malignant Ependymoma
Ependymoma Of Brain

Cerebellar Astrocytoma

Astrocytoma Of Cerebellum

Anaplastic Ependymoma

Ependymoma, Anaplastic

Undifferentiated Ependymoma

Cerebral Ventricle Cancer

Cerebral Ventricle Neoplasms	Cerebral Ventricle Neoplasm
Intraventricular Tumor Of Brain

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01468	BEND2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	BEND2	VGNC	VGNC:56521
Mus musculus	BEND2	MGD	MGI:3705232
Macaca mulatta	BEND2	VGNC	VGNC:70141
Canis familiaris	BEND2	VGNC	VGNC:53707
Rattus norvegicus	BEND2	RGD	RGD:7741042

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