2. Gene
  3. LHX2 - LIM homeobox 2 Gene

LHX2 - LIM homeobox 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as LH2; hLhx2

Gene ID: 9355 | Gene type: protein coding

About LHX2

Cytogenetic location: 9q33.3 Genomic coordinates (GRCh38): 9:124,011,768-124,033,301 (from NCBI)

This gene has 4 transcripts (splice variants), 222 orthologues and 20 paralogues. Biased expression in brain (RPKM 8.5), placenta (RPKM 1.0) and 2 other tissues.

Summary

This gene encodes a protein belonging to a large protein family, members of which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator. The protein can recapitulate or rescue phenotypes in Drosophila caused by a related protein, suggesting conservation of function during evolution. [provided by RefSeq, Jul 2008]

LHX2 Products(1)

mRNA Protein Name
NM_004789.4 NP_004780.3 LIM/homeobox protein Lhx2
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
20211142 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LHX2 Protein Structure

LIM

LIM: LIM domain (53 - 110)

LIM

LIM: LIM domain (115 - 170)

Homeobox

Homeobox: Homeobox domain (267 - 323)

  • 0
  • 100
  • 200
  • 300
  • 406 a.a.
Protein Preferred Names Protein Names

LIM/homeobox protein Lhx2

LIM HOX gene 2

LHX2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra LHX2 P50458 LGALSL Homo sapiens Q3ZCW2
Validated Y2H
32296183
Intra LHX2 P50458 ZNF511 Homo sapiens Q8NB15
Validated Y2H
32296183
Intra LHX2 P50458 MORF4L1 Homo sapiens Q9UBU8-2
Validated Y2H
32296183
Intra LHX2 P50458 TRAPPC2L Homo sapiens Q9UL33-2
Validated Y2H
32296183
Intra LHX2 P50458 TRAPPC2L Homo sapiens Q9UL33-2
Y2H Array
32296183
Intra LHX2 P50458 ANKS1A Homo sapiens Q49AR9
Validated Y2H
32296183
Intra LHX2 P50458 TCEANC Homo sapiens Q8N8B7-2
Validated Y2H
32296183
Intra LHX2 P50458 LDB1 Homo sapiens Q86U70-2
Validated Y2H
32296183
Intra LHX2 P50458 ZFP42 Homo sapiens Q96MM3
Validated Y2H
32296183
Intra LHX2 P50458 POU4F2 Homo sapiens Q12837
Validated Y2H
32296183
Intra LHX2 P50458 LONRF1 Homo sapiens Q17RB8
Validated Y2H
32296183
Intra LHX2 P50458 TCP11L1 Homo sapiens Q9NUJ3
Validated Y2H
32296183
Intra LHX2 P50458 PPIL1 Homo sapiens Q9Y3C6
Validated Y2H
32296183
Intra LHX2 P50458 OSMR Homo sapiens Q99650
Validated Y2H
32296183
Intra LHX2 P50458 LDB1 Homo sapiens Q86U70
Affinity Chrom
35140242
Intra LHX2 P50458 LDB1 Homo sapiens Q86U70
BioID
35140242
Intra LHX2 P50458 FLYWCH1 Homo sapiens Q4VC44
Validated Y2H
32296183
Intra LHX2 P50458 LNX1 Homo sapiens Q8TBB1
Y2H Prey Pooling
32296183
Intra LHX2 P50458 LNX1 Homo sapiens Q8TBB1
Validated Y2H
32296183
Intra LHX2 P50458 TLK1 Homo sapiens Q9UKI8
Validated Y2H
32296183
Intra LHX2 P50458 HOMER3 Homo sapiens Q9NSC5
Validated Y2H
32296183
Intra LHX2 P50458 BEND2 Homo sapiens Q8NDZ0
Validated Y2H
32296183
Intra LHX2 P50458 MORN3 Homo sapiens Q6PF18
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Aniridia 1

Aniridia

Congenital Aniridia

AN1

An

Cataract With Late-Onset Corneal Dystrophy

Aplasia Of Iris

Absent Iris

Irideremia

Aniridia Ii, Formerly

An2, Formerly

An2

Aniridia Type Ii

Aniridia, Type 1

An-1

Absence Of Iris

Agenesis Of Iris

Congenital Absence Of Iris

Hereditary Aniridia

Sporadic Aniridia
Coloboma Of Macula

Coloboma

Congenital Ocular Coloboma

Microphthalmia, Isolated, With Coloboma

Agenesis Of Macula

Hereditary Macular Coloboma

Ocular Coloboma

Coloboma Of Eye

Macular Coloboma

Uveoretinal Coloboma
Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder
Leber Plus Disease

Leber Congenital Amaurosis

Lca

Leber'S Amaurosis

Leber'S Disease

Amaurosis Congenita Of Leber

Amaurosis Congenita Of Leber, Type 1

Lhon Plus Disease

Congenital Absence Of The Rods And Cones

Congenital Retinal Blindness

Crb

Congenital Amaurosis Of Retinal Origin

Leber'S Congenital Amaurosis

Leber Congenital Amaurosis 1

Leber'S Congenital Tapetoretinal Degeneration

Leber'S Congenital Tapetoretinal Dysplasia

Lca1

Leber Congenital Amaurosis Type 1

Retinal Blindness, Congenital

Amaurosis, Leber Congenital

Dysgenesis Neuroepithelialis Retinae

Hereditary Epithelial Dysplasia Of Retina

Hereditary Retinal Aplasia

Heredoretinopathia Congenitalis

Leber Abiotrophy

Leber Congenital Tapetoretinal Degeneration

Lebers Congenital Amaurosis

Optic Atrophy, Hereditary, Leber
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
Fundus Dystrophy

Retinal Dystrophy

Retinal Dystrophies

Dystrophy, Retinal
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07632 LHX2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus LHX2 RGD RGD:71076
Felis catus LHX2 VGNC VGNC:102947
Macaca mulatta LHX2 VGNC VGNC:74262
Mus musculus LHX2 MGD MGI:96785
Canis familiaris LHX2 VGNC VGNC:42663
Bos taurus LHX2 VGNC VGNC:30872