2. Gene
  3. Esr1 - estrogen receptor 1 (alpha) Gene

Esr1 - estrogen receptor 1 (alpha) Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as ER; ERa; ESR; Estr; Estra; Nr3a1; ERalpha; ER-alpha

Gene ID: 13982 | Gene type: protein coding

About Esr1

Chromosome 10: 4,561,593-4,955,614 forward strand.GRCm39:CM001003.3

This gene has 10 transcripts (splice variants), 212 orthologues, 8 paralogues and is associated with 197 phenotypes. Biased expression in ovary adult (RPKM 13.9), subcutaneous fat pad adult (RPKM 12.1) and 7 other tissues.

Summary

This gene encodes an Estrogen Receptor, a member of the nuclear hormone family of intracellular receptors. The encoded protein, activated by the sex hormone estrogen, is a transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in Other tissues such as bone. Similar genes in human have been implicated in pathological processes including breast Cancer, endometrial Cancer, and osteoporosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

Esr1 Products(4)

mRNA Protein Name
NM_007956.5 NP_031982.1 estrogen receptor isoform 1
NM_001302533.1 NP_001289462.1 estrogen receptor isoform 2
NM_001302532.1 NP_001289461.1 estrogen receptor isoform 1
NM_001302531.1 NP_001289460.1 estrogen receptor isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables chromatin binding IDA
IDA: Inferred from direct assay
18202148 MGI
enables nuclear receptor activity IDA
IDA: Inferred from direct assay
15322135 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
8978696 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
9448000 MGI
enables transcription factor binding IPI
IPI: Inferred from physical interaction
19797124 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within androgen metabolic process IMP
IMP: Inferred from mutant phenotype
18755802 MGI
acts upstream of or within antral ovarian follicle growth IMP
IMP: Inferred from mutant phenotype
10976058 MGI
involved in cellular response to estradiol stimulus IDA
IDA: Inferred from direct assay
9448000 MGI
acts upstream of or within cellular response to estrogen stimulus IMP
IMP: Inferred from mutant phenotype
17901126 MGI
acts upstream of or within epithelial cell development IMP
IMP: Inferred from mutant phenotype
18755802 MGI
acts upstream of or within epithelial cell proliferation involved in mammary gland duct elongation IMP
IMP: Inferred from mutant phenotype
12021201 MGI
acts upstream of fibroblast proliferation IMP
IMP: Inferred from mutant phenotype
18755802 MGI
acts upstream of or within male gonad development IMP
IMP: Inferred from mutant phenotype
18755802 MGI
acts upstream of or within mammary gland alveolus development IMP
IMP: Inferred from mutant phenotype
10919287 MGI
acts upstream of or within mammary gland branching involved in pregnancy IMP
IMP: Inferred from mutant phenotype
10919287 MGI
acts upstream of or within positive regulation of fibroblast proliferation IMP
IMP: Inferred from mutant phenotype
18755802 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
17901126 MGI
acts upstream of or within prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis IMP
IMP: Inferred from mutant phenotype
18535112 MGI
acts upstream of or within prostate epithelial cord elongation IMP
IMP: Inferred from mutant phenotype
18535112 MGI
acts upstream of or within regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
15322135 MGI
acts upstream of or within regulation of branching involved in prostate gland morphogenesis IMP
IMP: Inferred from mutant phenotype
15665095 MGI
acts upstream of or within regulation of epithelial cell apoptotic process IMP
IMP: Inferred from mutant phenotype
17901126 MGI
acts upstream of or within regulation of inflammatory response IMP
IMP: Inferred from mutant phenotype
22659029 MGI
acts upstream of or within regulation of toll-like receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
22659029 MGI
involved in stem cell differentiation IDA
IDA: Inferred from direct assay
25655704 MGI
acts upstream of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
17901126 MGI
acts upstream of or within uterus development IGI
IGI: Inferred from genetic interaction
10976058 MGI
acts upstream of or within vagina development IGI
IGI: Inferred from genetic interaction
10976058 MGI
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
12845704 MGI
located in nucleus IDA
IDA: Inferred from direct assay
8999954 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Esr1 Protein Structure

Oest_recep

Oest_recep: pfam02159 (41 - 184)

NR_DBD_ER

NR_DBD_ER: cd07171 (183 - 264)

NR_LBD_ER

NR_LBD_ER: cd06949 (313 - 550)

ESR1_C

ESR1_C: pfam12743 (555 - 598)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 599 a.a.
Protein Preferred Names Protein Names

estrogen receptor

C-terminally-truncated estrogen receptor alpha product-4

C-terminally-truncated estrogen receptor alpha product-5

C-terminally-truncated estrogen receptor alpha product-6

C-terminally-truncated estrogen receptor alpha product-7

estradiol receptor

nuclear receptor subfamily 3 group A member 1

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-136255 Camizestrant Inhibitor 98.04% Phase 3
Pre-clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-147165 VT02956 Inhibitor 99.58% Unkown
HY-101119 GLL398 Degrader / Unkown
HY-149480 ERD-3111 Degrader 98.72% Unkown
HY-RS04529 ESR1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS04530 Esr1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS04531 Esr1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-147165A VT02956 hydrochloride Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Esr1 NCBI NCBI:2099