2. Gene
  3. CRMP1 - collapsin response mediator protein 1 Gene

CRMP1 - collapsin response mediator protein 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as DRP1; DRP-1; CRMP-1; DPYSL1; ULIP-3

Gene ID: 1400 | Gene type: protein coding

About CRMP1

Cytogenetic location: 4p16.2 Genomic coordinates (GRCh38): 4:5,820,764-5,893,086 (from NCBI)

This gene has 6 transcripts (splice variants), 195 orthologues and 5 paralogues. Biased expression in brain (RPKM 34.7), endometrium (RPKM 8.3) and 8 other tissues.

Summary

This gene encodes a member of a family of cytosolic phosphoproteins expressed exclusively in the nervous system. The encoded protein is thought to be a part of the semaphorin signal transduction pathway implicated in semaphorin-induced growth cone collapse during neural development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

CRMP1 Products(4)

mRNA Protein Name
NM_001014809.3 NP_001014809.1 dihydropyrimidinase-related protein 1 isoform 1
NM_001288661.2 NP_001275590.1 dihydropyrimidinase-related protein 1 isoform 3
NM_001288662.1 NP_001275591.1 dihydropyrimidinase-related protein 1 isoform 4
NM_001313.5 NP_001304.1 dihydropyrimidinase-related protein 1 isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables filamin binding IPI
IPI: Inferred from physical interaction
25358863 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
24722188 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15383276 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of neuron projection development IGI
IGI: Inferred from genetic interaction
25358863 GOA
Cellular Component GO Annotation Evidence Reference Source
located in midbody IDA
IDA: Inferred from direct assay
19799413 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CRMP1 Protein Structure

Amidohydro_1

Amidohydro_1: Amidohydrolase family (64 - 413)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 572 a.a.
Protein Preferred Names Protein Names

dihydropyrimidinase-related protein 1

dihydropyrimidinase-like 1

CRMP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
CRMP1 Q14194 DPYSL3 Homo sapiens Q14195-2
Validated Y2H
25416956
Intra
CRMP1 Q14194 DPYSL3 Homo sapiens Q14195-2
Validated Y2H
32296183
Intra
CRMP1 Q14194 DPYSL3 Homo sapiens Q14195-2
Y2H Array
25416956
Intra
CRMP1 Q14194 DPYSL3 Homo sapiens Q14195-2
Y2H Prey Pooling
25416956
Intra
CRMP1 Q14194 DPYSL2 Homo sapiens Q16555
Validated Y2H
32296183
Intra
CRMP1 Q14194 DPYSL2 Homo sapiens Q16555
Y2H
21900206
Intra
CRMP1 Q14194 DPYSL2 Homo sapiens Q16555
Y2H Array
24722188
Intra
CRMP1 Q14194 BDNF Homo sapiens P23560-2
Validated Y2H
32814053
Intra
CRMP1 Q14194 BDNF Homo sapiens P23560-2
Y2H Pooling
32814053
Intra
CRMP1 Q14194 BDNF Homo sapiens P23560-2
Y2H Array
32814053
Intra
CRMP1 Q14194 AP3M1 Homo sapiens Q9Y2T2
Validated Y2H
32296183
Intra
CRMP1 Q14194 AP3M1 Homo sapiens Q9Y2T2
Y2H Array
25416956
Intra
CRMP1 Q14194 HSP90AA1 Homo sapiens P07900
Validated Y2H
32814053
Intra
CRMP1 Q14194 HSP90AA1 Homo sapiens P07900
Y2H Array
32814053
Intra
CRMP1 Q14194 HSP90AA1 Homo sapiens P07900
Y2H Pooling
32814053
Intra
CRMP1 Q14194 VIM Homo sapiens P08670
Y2H
15383276
Intra
CRMP1 Q14194 VIM Homo sapiens P08670
Pull Down
15383276
Intra
CRMP1 Q14194 VIM Homo sapiens P08670
Y2H
21900206
Intra
CRMP1 Q14194 HTT Homo sapiens P42858
Y2H
15383276
Intra
CRMP1 Q14194 HTT Homo sapiens P42858
Pull Down
15383276
Intra
CRMP1 Q14194 CRYAB Homo sapiens P02511
Validated Y2H
32814053
Intra
CRMP1 Q14194 CRYAB Homo sapiens P02511
Y2H Pooling
32814053
Intra
CRMP1 Q14194 CRYAB Homo sapiens P02511
Y2H Array
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CRMP1 Proteins

Cat. No. Product Name Accession Purity
HY-P71547 CRMP1 Protein, Human Q14194 (M1-G572) ≥95%

CRMP1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82196 CRMP1 Antibody (YA1941) WB, IHC-P, ICC/IF, IP, FC Human, Mouse, Rat

Related Diseases

Diseases Alias
Sialuria

Sialuria, French Type

French Type Sialuria

Sialuria French Type

Sialic Acid Storage Disease

Sialic Acid Storage Disease, Finnish Type

Infantile Sialic Acid Storage Disease
Weyers Acrofacial Dysostosis

Curry-Hall Syndrome

Weyers Acrodental Dysostosis

WAD

Acrodental Dysostosis Of Weyers

Acrofacial Dysostosis, Weyers Type

Acrofacial Dysostosis Of Weyers

Curry Hall Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03190 CRMP1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta CRMP1 VGNC VGNC:71494
Mus musculus CRMP1 MGD MGI:107793
Canis familiaris CRMP1 VGNC VGNC:39624
Bos taurus CRMP1 VGNC VGNC:27720
Rattus norvegicus CRMP1 RGD RGD:2407
Felis catus CRMP1 VGNC VGNC:61186
Others CRMP1 NCBI