MYO3B - myosin IIIB Gene

Homo sapiens

Gene ID: 140469 | Gene type: protein coding

About MYO3B

Cytogenetic location: 2q31.1 Genomic coordinates (GRCh38): 2:170,178,147-170,655,167 (from NCBI)

This gene has 9 transcripts (splice variants), 187 orthologues and 43 paralogues. Biased expression in kidney (RPKM 2.4), urinary bladder (RPKM 2.3) and 4 other tissues.

Summary

This gene encodes one of the class III myosins. Myosins are ATPases, activated by actin, that move along actin filaments in the cell. This class of myosins are characterized by an amino-terminal kinase domain and shown to be present in photoreceptors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014]

MYO3B Products(2)

mRNA	Protein	Name
NM_001083615.4	NP_001077084.2	myosin-IIIb isoform 1
NM_138995.5	NP_620482.3	myosin-IIIb isoform 2

MYO3B Protein Structure

Pkinase

Myosin_head

0
300
600
900
1200
1341 a.a.

Protein Preferred Names

Protein Names

myosin-IIIb

Related Diseases

Diseases

Alias

Deafness, Autosomal Recessive 30

DFNB30	Autosomal Recessive Nonsyndromic Deafness 30
Autosomal Recessive Deafness 30	Deafness, Autosomal Recessive, 30
Deafness, Autosomal Recessive, Type 30

Entropion

Autosomal Recessive Nonsyndromic Deafness

Deafness, Autosomal Recessive, Nonsyndromic

Bardet-Biedl Syndrome

Bbs	Biedl-Bardet Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08945	MYO3B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	MYO3B	VGNC	VGNC:74961
Mus musculus	MYO3B	MGD	MGI:2448580
Rattus norvegicus	MYO3B	RGD	RGD:1560313
Canis familiaris	MYO3B	VGNC	VGNC:49692
Felis catus	MYO3B	VGNC	VGNC:63689
Bos taurus	MYO3B	VGNC	VGNC:31825

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