HSP90AB1 - heat shock protein 90 alpha family class B member 1 Gene

Homo sapiens

Also known as HSP84; HSPC2; HSPCB; D6S182; HSP90B

Gene ID: 3326 | Gene type: protein coding

About HSP90AB1

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:44,246,194-44,253,883 (from NCBI)

This gene has 4 transcripts (splice variants), 229 orthologues, 3 paralogues and is associated with 64 phenotypes. Ubiquitous expression in ovary (RPKM 514.6), brain (RPKM 324.0) and 25 other tissues.

Summary

This gene encodes a member of the heat shock protein 90 family; these proteins are involved in signal transduction, protein folding and degradation and morphological evolution. This gene encodes the constitutive form of the cytosolic 90 kDa heat-shock protein and is thought to play a role in gastric Apoptosis and inflammation. Alternative splicing results in multiple transcript variants. Pseudogenes have been identified on multiple chromosomes. [provided by RefSeq, Dec 2012]

HSP90AB1 Products(6)

mRNA	Protein	Name
NM_001271969.2	NP_001258898.1	heat shock protein HSP 90-beta isoform a
NM_001271970.2	NP_001258899.1	heat shock protein HSP 90-beta isoform a
NM_001271971.2	NP_001258900.1	heat shock protein HSP 90-beta isoform b
NM_001271972.2	NP_001258901.1	heat shock protein HSP 90-beta isoform c
NM_001371238.1	NP_001358167.1	heat shock protein HSP 90-beta isoform a
NM_007355.4	NP_031381.2	heat shock protein HSP 90-beta isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP binding	IDA IDA: Inferred from direct assay	10811660	GOA
enables ATP binding	IMP IMP: Inferred from mutant phenotype	10543959	GOA
enables ATP-dependent protein binding	IPI IPI: Inferred from physical interaction	10543959	GOA
enables DNA polymerase binding	IPI IPI: Inferred from physical interaction	10197982	GOA
enables disordered domain specific binding	IPI IPI: Inferred from physical interaction	11785981	GOA
enables double-stranded RNA binding	IDA IDA: Inferred from direct assay	21266579	GOA
enables heat shock protein binding	IPI IPI: Inferred from physical interaction	20353823	GOA
enables histone deacetylase binding	IPI IPI: Inferred from physical interaction	16809764	GOA
enables histone methyltransferase binding	IPI IPI: Inferred from physical interaction	24880080	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	21183720	GOA
enables kinase binding	IPI IPI: Inferred from physical interaction	20353823	GOA
enables peptide binding	IPI IPI: Inferred from physical interaction	20599762	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11036079	GOA
enables protein dimerization activity	IDA IDA: Inferred from direct assay	7588731	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	10811660	GOA
enables receptor ligand inhibitor activity	IDA IDA: Inferred from direct assay	20599762	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	16207813	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in chaperone-mediated protein complex assembly	IDA IDA: Inferred from direct assay	10811660	GOA
involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	24613385	GOA
involved in positive regulation of cell differentiation	IMP IMP: Inferred from mutant phenotype	18239673	GOA
involved in positive regulation of protein localization to cell surface	IDA IDA: Inferred from direct assay	23431407	GOA
involved in positive regulation of transforming growth factor beta receptor signaling pathway	IDA IDA: Inferred from direct assay	24613385	GOA
involved in regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	22843495	GOA
involved in regulation of protein ubiquitination	IDA IDA: Inferred from direct assay	16809764	GOA
involved in supramolecular fiber organization	IMP IMP: Inferred from mutant phenotype	24466266	GOA
involved in telomerase holoenzyme complex assembly	IDA IDA: Inferred from direct assay	10197982	GOA
acts upstream of positive effect telomere maintenance via telomerase	IDA IDA: Inferred from direct assay	10197982	GOA
involved in virion attachment to host cell	IMP IMP: Inferred from mutant phenotype	24098578	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of COP9 signalosome	IDA IDA: Inferred from direct assay	18850735	GOA
part of HSP90-CDC37 chaperone complex	IDA IDA: Inferred from direct assay	21855797	GOA
part of aryl hydrocarbon receptor complex	IDA IDA: Inferred from direct assay	15581363	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	10791971	GOA
located in extracellular region	IDA IDA: Inferred from direct assay	20599762	GOA
located in nucleus	IDA IDA: Inferred from direct assay	18239673	GOA
part of protein folding chaperone complex	IMP IMP: Inferred from mutant phenotype	17517623	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	10811660	GOA
part of protein-containing complex	IMP IMP: Inferred from mutant phenotype	10543959	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HSP90AB1 Protein Structure

HATPase_c

HSP90

0
200
400
600
724 a.a.

Protein Preferred Names

Protein Names

heat shock protein HSP 90-beta

HSP90-beta

HSP90AB1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	HSP90AB1	P08238	FGFR1	Homo sapiens	P11362	Lumier	22939624
Intra	HSP90AB1	P08238	CDK14	Homo sapiens	O94921	Anti Tag CoIP	22939624
Intra	HSP90AB1	P08238	CDK14	Homo sapiens	O94921	Lumier	22939624
Intra	HSP90AB1	P08238	GSK3A	Homo sapiens	P49840	Lumier	22939624
Intra	HSP90AB1	P08238	GSK3A	Homo sapiens	P49840	Anti Tag CoIP	22939624
Intra	HSP90AB1	P08238	FKBP4	Homo sapiens	Q02790	Anti Tag CoIP	25036637
Intra	HSP90AB1	P08238	FKBP4	Homo sapiens	Q02790	Solution Sedimentation	21170051
Intra	HSP90AB1	P08238	PTGES3	Homo sapiens	Q15185	SLCA	21183720
Intra	HSP90AB1	P08238	PTGES3	Homo sapiens	Q15185	NMR	21183720
Intra	HSP90AB1	P08238	PTGES3	Homo sapiens	Q15185	Anti Tag CoIP	25036637
Intra	HSP90AB1	P08238	PTGES3	Homo sapiens	Q15185	Y2H	21988832
Intra	HSP90AB1	P08238	TTC4	Homo sapiens	O95801	Anti Tag CoIP	25036637
Intra	HSP90AB1	P08238	STIP1	Homo sapiens	P31948	SPR	21170051
Intra	HSP90AB1	P08238	STIP1	Homo sapiens	P31948	Anti Tag CoIP	35271311
Intra	HSP90AB1	P08238	STIP1	Homo sapiens	P31948	Anti Tag CoIP	25036637
Intra	HSP90AB1	P08238	PRKD1	Homo sapiens	Q15139	Lumier	22939624
Intra	HSP90AB1	P08238	PRKAA1	Homo sapiens	Q13131	Lumier	22939624
Intra	HSP90AB1	P08238	AMPD3	Homo sapiens	Q01432	Anti Tag CoIP	25910212
Intra	HSP90AB1	P08238	HASPIN	Homo sapiens	Q8TF76	Anti Tag CoIP	22939624
Intra	HSP90AB1	P08238	CDK3	Homo sapiens	Q00526	Lumier	22939624
Intra	HSP90AB1	P08238	CDK7	Homo sapiens	P50613	Lumier	22939624
Intra	HSP90AB1	P08238	FER	Homo sapiens	P16591	Lumier	22939624
Intra	HSP90AB1	P08238	CDK9	Homo sapiens	P50750	Lumier	22939624
Intra	HSP90AB1	P08238	CDK9	Homo sapiens	P50750	Anti Tag CoIP	33961781
Intra	HSP90AB1	P08238	TYK2	Homo sapiens	P29597	Anti Tag CoIP	22939624
Intra	HSP90AB1	P08238	PTK6	Homo sapiens	Q13882	Lumier	22939624
Intra	HSP90AB1	P08238	FGR	Homo sapiens	P09769	Lumier	22939624
Intra	HSP90AB1	P08238	MAPK15	Homo sapiens	Q8TD08	Lumier	22939624
Intra	HSP90AB1	P08238	TESK2	Homo sapiens	Q96S53	Lumier	22939624
Intra	HSP90AB1	P08238	LIMK2	Homo sapiens	P53671	Lumier	22939624
Intra	HSP90AB1	P08238	LIMK2	Homo sapiens	P53671	Anti Tag CoIP	22939624
Intra	HSP90AB1	P08238	CDK10	Homo sapiens	Q15131	Anti Tag CoIP	22939624
Intra	HSP90AB1	P08238	NEK8	Homo sapiens	Q86SG6	Lumier	22939624
Intra	HSP90AB1	P08238	BLK	Homo sapiens	P51451	Lumier	22939624
Intra	HSP90AB1	P08238	CHORDC1	Homo sapiens	Q9UHD1	Validated Y2H	32296183
Intra	HSP90AB1	P08238	CHORDC1	Homo sapiens	Q9UHD1	Y2H Array	32296183
Intra	HSP90AB1	P08238	CHORDC1	Homo sapiens	Q9UHD1	Y2H Prey Pooling	32296183
Intra	HSP90AB1	P08238	CDC37L1	Homo sapiens	Q7L3B6	Y2H Prey Pooling	25416956
Intra	HSP90AB1	P08238	CDC37L1	Homo sapiens	Q7L3B6	Anti Tag CoIP	33961781
Intra	HSP90AB1	P08238	CDC37L1	Homo sapiens	Q7L3B6	Validated Y2H	25416956
Intra	HSP90AB1	P08238	CDC37L1	Homo sapiens	Q7L3B6	Y2H	21988832
Intra	HSP90AB1	P08238	CDC37	Homo sapiens	Q16543	Lumier	22939624
Intra	HSP90AB1	P08238	CDC37	Homo sapiens	Q16543	Anti Tag CoIP	33961781
Intra	HSP90AB1	P08238	CDC37	Homo sapiens	Q16543	Anti Tag CoIP	25036637
Intra	HSP90AB1	P08238	CDK4	Homo sapiens	P11802	Anti Tag CoIP	22939624
Intra	HSP90AB1	P08238	CDK4	Homo sapiens	P11802	Anti Tag CoIP	33961781
Intra	HSP90AB1	P08238	CDK4	Homo sapiens	P11802	Lumier	22939624
Intra	HSP90AB1	P08238	CDK6	Homo sapiens	Q00534	Anti Tag CoIP	22939624
Intra	HSP90AB1	P08238	CDK6	Homo sapiens	Q00534	Lumier	22939624
Intra	HSP90AB1	P08238	AKT2	Homo sapiens	P31751	Anti Tag CoIP	22939624
Intra	HSP90AB1	P08238	AKT1	Homo sapiens	P31749	Anti Bait CoIP	20650008
Intra	HSP90AB1	P08238	EGFR	Homo sapiens	P00533	Ub Reconstruction	20029029
Intra	HSP90AB1	P08238	EGFR	Homo sapiens	P00533	Lumier	24658140
Intra	HSP90AB1	P08238	EGFR	Homo sapiens	P00533	Ub Reconstruction	24658140
Intra	HSP90AB1	P08238	STK11	Homo sapiens	Q15831	Lumier	22939624
Intra	HSP90AB1	P08238	FKBP5	Homo sapiens	Q13451	Fluorescence	30382094
Intra	HSP90AB1	P08238	FKBP5	Homo sapiens	Q13451	ATPase Assay	30382094
Intra	HSP90AB1	P08238	FKBP5	Homo sapiens	Q13451	Crosslink	30382094
Intra	HSP90AB1	P08238	FKBP5	Homo sapiens	Q13451	Solution Sedimentation	21170051
Intra	HSP90AB1	P08238	FKBP5	Homo sapiens	Q13451	ITC	30382094
Intra	HSP90AB1	P08238	FKBP5	Homo sapiens	Q13451	Anti Tag CoIP	25036637
Intra	HSP90AB1	P08238	FKBP5	Homo sapiens	Q13451	SAXS	30382094
Intra	HSP90AB1	P08238	FKBP5	Homo sapiens	Q13451	NMR	30382094
Intra	HSP90AB1	P08238	MAP2K5	Homo sapiens	Q13163	Lumier	22939624
Intra	HSP90AB1	P08238	IKBKE	Homo sapiens	Q14164	TAP	14743216
Intra	HSP90AB1	P08238	MYO3B	Homo sapiens	Q8WXR4	Lumier	22939624
Intra	HSP90AB1	P08238	PPP5C	Homo sapiens	P53041	Anti Tag CoIP	25036637
Intra	HSP90AB1	P08238	PPP5C	Homo sapiens	P53041	Anti Tag CoIP	35271311
Intra	HSP90AB1	P08238	RPL11	Homo sapiens	P62913	Anti Tag CoIP	25910212
Intra	HSP90AB1	P08238	MAP3K8	Homo sapiens	P41279	TAP	14743216
Intra	HSP90AB1	P08238	MAP3K8	Homo sapiens	P41279	Lumier	22939624
Intra	HSP90AB1	P08238	TBK1	Homo sapiens	Q9UHD2	TAP	14743216
Intra	HSP90AB1	P08238	TBK1	Homo sapiens	Q9UHD2	Lumier	22939624
Intra	HSP90AB1	P08238	RPAP3	Homo sapiens	Q9H6T3	Anti Tag CoIP	35271311
Intra	HSP90AB1	P08238	STUB1	Homo sapiens	Q9UNE7	GMS	20618441
Intra	HSP90AB1	P08238	STUB1	Homo sapiens	Q9UNE7	Anti Tag CoIP	25036637
Intra	HSP90AB1	P08238	ALK	Homo sapiens	Q9UM73	Lumier	22939624
Intra	HSP90AB1	P08238	MAP3K14	Homo sapiens	Q99558	TAP	14743216
Intra	HSP90AB1	P08238	CUL1	Homo sapiens	Q13616	Lumier	22939624
Intra	HSP90AB1	P08238	ARAF	Homo sapiens	P10398	Anti Tag CoIP	22939624
Intra	HSP90AB1	P08238	ARAF	Homo sapiens	P10398	Lumier	22939624
Intra	HSP90AB1	P08238	BRAF	Homo sapiens	P15056	Lumier	22939624
Intra	HSP90AB1	P08238	MAPT	Homo sapiens	P10636-8	Crosslink	30382094
Intra	HSP90AB1	P08238	MAPT	Homo sapiens	P10636-8	NMR	24581495
Intra	HSP90AB1	P08238	MAPT	Homo sapiens	P10636-8	SAXS	30382094
Intra	HSP90AB1	P08238	MAPT	Homo sapiens	P10636-8	NMR	30382094
Intra	HSP90AB1	P08238	MAPT	Homo sapiens	P10636-8	Fluorescence	30382094
Intra	HSP90AB1	P08238	CDK11A	Homo sapiens	Q9UQ88	Lumier	22939624
Intra	HSP90AB1	P08238	NR1I2	Homo sapiens	O75469	Anti Tag CoIP	22939624
Intra	HSP90AB1	P08238	MAPK4	Homo sapiens	P31152	Anti Tag CoIP	22939624
Intra	HSP90AB1	P08238	DYRK4	Homo sapiens	Q9NR20	Lumier	22939624
Intra	HSP90AB1	P08238	PSKH1	Homo sapiens	P11801	Lumier	22939624
Intra	HSP90AB1	P08238	PSKH1	Homo sapiens	P11801	Anti Tag CoIP	22939624
Intra	HSP90AB1	P08238	MAP3K9	Homo sapiens	P80192	Anti Tag CoIP	22939624
Intra	HSP90AB1	P08238	MAP3K9	Homo sapiens	P80192	Lumier	22939624
Intra	HSP90AB1	P08238	PRKX	Homo sapiens	P51817	Lumier	22939624
Intra	HSP90AB1	P08238	AHSA1	Homo sapiens	O95433	GMS	20618441
Intra	HSP90AB1	P08238	AHSA1	Homo sapiens	O95433	Anti Tag CoIP	25036637
Intra	HSP90AB1	P08238	AHSA1	Homo sapiens	O95433	ATPase Assay	30382094
Intra	HSP90AB1	P08238	CUL3	Homo sapiens	Q13618	Anti Tag CoIP	22939624
Intra	HSP90AB1	P08238	CUL2	Homo sapiens	Q13617	Lumier	22939624
Intra	HSP90AB1	P08238	STK38	Homo sapiens	Q15208	Anti Tag CoIP	22939624
Intra	HSP90AB1	P08238	FYN	Homo sapiens	P06241	Lumier	22939624
Intra	HSP90AB1	P08238	YES1	Homo sapiens	P07947	Lumier	22939624
Intra	HSP90AB1	P08238	TNK2	Homo sapiens	Q07912	Lumier	22939624
Intra	HSP90AB1	P08238	FAM162A	Homo sapiens	Q96A26	Y2H	16698020
Intra	HSP90AB1	P08238	AURKB	Homo sapiens	Q96GD4	Anti Tag CoIP	22939624
Intra	HSP90AB1	P08238	AURKB	Homo sapiens	Q96GD4	Lumier	22939624
Intra	HSP90AB1	P08238	BTK	Homo sapiens	Q06187	Lumier	22939624
Intra	HSP90AB1	P08238	BTK	Homo sapiens	Q06187	Anti Tag CoIP	22939624
Intra	HSP90AB1	P08238	NEK11	Homo sapiens	Q8NG66	Lumier	22939624
Intra	HSP90AB1	P08238	DYRK1B	Homo sapiens	Q9Y463	Lumier	22939624
Intra	HSP90AB1	P08238	HIPK4	Homo sapiens	Q8NE63	Lumier	22939624
Intra	HSP90AB1	P08238	EIF2AK1	Homo sapiens	Q9BQI3	Lumier	22939624
Intra	HSP90AB1	P08238	ERBB2	Homo sapiens	P04626	Anti Tag CoIP	22939624
Intra	HSP90AB1	P08238	ERBB2	Homo sapiens	P04626	Anti Bait CoIP	20650008
Intra	HSP90AB1	P08238	ROR2	Homo sapiens	Q01974	Anti Tag CoIP	22939624
Intra	HSP90AB1	P08238	MUSK	Homo sapiens	O15146	Lumier	22939624
Intra	HSP90AB1	P08238	MUSK	Homo sapiens	O15146	Anti Tag CoIP	22939624
Intra	HSP90AB1	P08238	TSSK1B	Homo sapiens	Q9BXA7	Lumier	22939624
Intra	HSP90AB1	P08238	AMHR2	Homo sapiens	Q16671	Lumier	22939624
Intra	HSP90AB1	P08238	INSRR	Homo sapiens	P14616	Lumier	22939624
Intra	HSP90AB1	P08238	MYLK4	Homo sapiens	Q86YV6	Lumier	22939624
Intra	HSP90AB1	P08238	STYK1	Homo sapiens	Q6J9G0	Lumier	22939624
Intra	HSP90AB1	P08238	FBXO24	Homo sapiens	O75426	Lumier	22939624
Intra	HSP90AB1	P08238	KLHL38	Homo sapiens	Q2WGJ6	Lumier	22939624
Intra	HSP90AB1	P08238	KLHL38	Homo sapiens	Q2WGJ6	Anti Tag CoIP	22939624
Intra	HSP90AB1	P08238	RGS6	Homo sapiens	P49758	Anti Tag CoIP	22939624
Intra	HSP90AB1	P08238	AIP	Homo sapiens	O00170	SPR	21170051
Intra	HSP90AB1	P08238	AIP	Homo sapiens	O00170	Solution Sedimentation	21170051
Intra	HSP90AB1	P08238	AIP	Homo sapiens	O00170	Anti Tag CoIP	25036637
Intra	HSP90AB1	P08238	EPHB6	Homo sapiens	O15197	Lumier	22939624
Intra	HSP90AB1	P08238	PRKN	Homo sapiens	O60260	Lumier	22939624
Intra	HSP90AB1	P08238	ERBB3	Homo sapiens	P21860	Lumier	22939624
Intra	HSP90AB1	P08238	GRK6	Homo sapiens	P43250	Lumier	22939624
Intra	HSP90AB1	P08238	FKBP8	Homo sapiens	Q14318	Anti Tag CoIP	25036637
Intra	HSP90AB1	P08238	CSNK1E	Homo sapiens	P49674	Anti Tag CoIP	22939624
Intra	HSP90AB1	P08238	MATK	Homo sapiens	P42679	Anti Tag CoIP	22939624
Intra	HSP90AB1	P08238	MATK	Homo sapiens	P42679	Lumier	22939624
Intra	HSP90AB1	P08238	ERBB4	Homo sapiens	Q15303	Anti Tag CoIP	22939624
Intra	HSP90AB1	P08238	ERBB4	Homo sapiens	Q15303	Lumier	22939624
Intra	HSP90AB1	P08238	CHUK	Homo sapiens	O15111	TAP	14743216
Intra	HSP90AB1	P08238	CHUK	Homo sapiens	O15111	Anti Tag CoIP	33961781
Intra	HSP90AB1	P08238	IKBKG	Homo sapiens	Q9Y6K9	TAP	14743216
Intra	HSP90AB1	P08238	MAP4K1	Homo sapiens	Q92918	Lumier	22939624
Intra	HSP90AB1	P08238	RPS6KA1	Homo sapiens	Q15418	Lumier	22939624
Intra	HSP90AB1	P08238	CHEK1	Homo sapiens	O14757	Anti Tag CoIP	22939624
Intra	HSP90AB1	P08238	CHEK1	Homo sapiens	O14757	Lumier	22939624

Cross: Cross-species interaction Intra: Intraspecies interaction

HSP90AB1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80714	Hsp90 alpha/beta Antibody	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat

Related Diseases

Diseases

Alias

Powassan Encephalitis

Powassan Encephalitis Virus Infection

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06418	HSP90AB1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-123035	Gamendazole	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	HSP90AB1	VGNC	VGNC:55918
Macaca mulatta	HSP90AB1	VGNC	VGNC:81078
Mus musculus	HSP90AB1	MGD	MGI:96247
Rattus norvegicus	HSP90AB1	RGD	RGD:1303075
Others	HSP90AB1	NCBI

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