HSP90AB1 - heat shock protein 90 alpha family class B member 1 Gene

Homo sapiens

Also known as HSP84; HSPC2; HSPCB; D6S182; HSP90B

Gene ID: 3326 | Gene type: protein coding

About HSP90AB1

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:44,246,194-44,253,883 (from NCBI)

This gene has 4 transcripts (splice variants), 229 orthologues, 3 paralogues and is associated with 64 phenotypes. Ubiquitous expression in ovary (RPKM 514.6), brain (RPKM 324.0) and 25 other tissues.

Summary

This gene encodes a member of the heat shock protein 90 family; these proteins are involved in signal transduction, protein folding and degradation and morphological evolution. This gene encodes the constitutive form of the cytosolic 90 kDa heat-shock protein and is thought to play a role in gastric Apoptosis and inflammation. Alternative splicing results in multiple transcript variants. Pseudogenes have been identified on multiple chromosomes. [provided by RefSeq, Dec 2012]

HSP90AB1 Products(6)

mRNA	Protein	Name
NM_001271969.2	NP_001258898.1	heat shock protein HSP 90-beta isoform a
NM_001271970.2	NP_001258899.1	heat shock protein HSP 90-beta isoform a
NM_001271971.2	NP_001258900.1	heat shock protein HSP 90-beta isoform b
NM_001271972.2	NP_001258901.1	heat shock protein HSP 90-beta isoform c
NM_001371238.1	NP_001358167.1	heat shock protein HSP 90-beta isoform a
NM_007355.4	NP_031381.2	heat shock protein HSP 90-beta isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP binding	IDA IDA: Inferred from direct assay	10811660	GOA
enables ATP binding	IMP IMP: Inferred from mutant phenotype	10543959	GOA
enables ATP-dependent protein binding	IPI IPI: Inferred from physical interaction	10543959	GOA
enables DNA polymerase binding	IPI IPI: Inferred from physical interaction	10197982	GOA
enables disordered domain specific binding	IPI IPI: Inferred from physical interaction	11785981	GOA
enables double-stranded RNA binding	IDA IDA: Inferred from direct assay	21266579	GOA
enables heat shock protein binding	IPI IPI: Inferred from physical interaction	20353823	GOA
enables histone deacetylase binding	IPI IPI: Inferred from physical interaction	16809764	GOA
enables histone methyltransferase binding	IPI IPI: Inferred from physical interaction	24880080	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	21183720	GOA
enables kinase binding	IPI IPI: Inferred from physical interaction	20353823	GOA
enables peptide binding	IPI IPI: Inferred from physical interaction	20599762	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11036079	GOA
enables protein dimerization activity	IDA IDA: Inferred from direct assay	7588731	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	10811660	GOA
enables receptor ligand inhibitor activity	IDA IDA: Inferred from direct assay	20599762	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	16207813	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in chaperone-mediated protein complex assembly	IDA IDA: Inferred from direct assay	10811660	GOA
involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	24613385	GOA
involved in positive regulation of cell differentiation	IMP IMP: Inferred from mutant phenotype	18239673	GOA
involved in positive regulation of protein localization to cell surface	IDA IDA: Inferred from direct assay	23431407	GOA
involved in positive regulation of transforming growth factor beta receptor signaling pathway	IDA IDA: Inferred from direct assay	24613385	GOA
involved in regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	22843495	GOA
involved in regulation of protein ubiquitination	IDA IDA: Inferred from direct assay	16809764	GOA
involved in supramolecular fiber organization	IMP IMP: Inferred from mutant phenotype	24466266	GOA
involved in telomerase holoenzyme complex assembly	IDA IDA: Inferred from direct assay	10197982	GOA
acts upstream of positive effect telomere maintenance via telomerase	IDA IDA: Inferred from direct assay	10197982	GOA
involved in virion attachment to host cell	IMP IMP: Inferred from mutant phenotype	24098578	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of COP9 signalosome	IDA IDA: Inferred from direct assay	18850735	GOA
part of HSP90-CDC37 chaperone complex	IDA IDA: Inferred from direct assay	21855797	GOA
part of aryl hydrocarbon receptor complex	IDA IDA: Inferred from direct assay	15581363	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	10791971	GOA
located in extracellular region	IDA IDA: Inferred from direct assay	20599762	GOA
located in nucleus	IDA IDA: Inferred from direct assay	18239673	GOA
part of protein folding chaperone complex	IMP IMP: Inferred from mutant phenotype	17517623	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	10811660	GOA
part of protein-containing complex	IMP IMP: Inferred from mutant phenotype	10543959	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HSP90AB1 Protein Structure

HATPase_c

HSP90

0
200
400
600
724 a.a.

Protein Preferred Names

Protein Names

heat shock protein HSP 90-beta

HSP90-beta

Related Diseases

Diseases

Alias

Powassan Encephalitis

Powassan Encephalitis Virus Infection

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-123035	Gamendazole	Inhibitor	/	Unkown
HY-RS06418	HSP90AB1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	HSP90AB1	VGNC	VGNC:55918
Macaca mulatta	HSP90AB1	VGNC	VGNC:81078
Mus musculus	HSP90AB1	MGD	MGI:96247
Rattus norvegicus	HSP90AB1	RGD	RGD:1303075
Others	HSP90AB1	NCBI

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