2. Gene
  3. Ezh1 - enhancer of zeste 1 polycomb repressive complex 2 subunit Gene

Ezh1 - enhancer of zeste 1 polycomb repressive complex 2 subunit Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as ENX-2

Gene ID: 14055 | Gene type: protein coding

About Ezh1

Chromosome 11: 101,081,941-101,117,289 reverse strand.GRCm39:CM001004.3

This gene has 9 transcripts (splice variants), 234 orthologues, 20 paralogues and is associated with 13 phenotypes. Ubiquitous expression in lung adult (RPKM 16.7), kidney adult (RPKM 16.3) and 28 other tissues.

Summary

This gene encodes a member of the Polycomb-group (PcG) family. The encoded protein is interchangeable with the related Enhancer of zeste 2 (EZH2) protein as a core component of the polycomb repressive complex 2 (PRC2), which methylates histone H3 at lysine 27 and results in the transcriptional repression of affected target genes. This complex is involved in carrying out cell-fate decisions during embryonic stem cell differentiation. [provided by RefSeq, Sep 2014]

Ezh1 Products(13)

mRNA Protein Name
NM_001403815.1 NP_001390744.1 histone-lysine N-methyltransferase EZH1 isoform 9
NM_001403812.1 NP_001390741.1 histone-lysine N-methyltransferase EZH1 isoform 6
NM_001403811.1 NP_001390740.1 histone-lysine N-methyltransferase EZH1 isoform 5
NM_001403809.1 NP_001390738.1 histone-lysine N-methyltransferase EZH1 isoform 3
NM_001403822.1 NP_001390751.1 histone-lysine N-methyltransferase EZH1 isoform 4
NM_001403807.1 NP_001390736.1 histone-lysine N-methyltransferase EZH1 isoform 2
NM_001403821.1 NP_001390750.1 histone-lysine N-methyltransferase EZH1 isoform 1
NM_001403814.1 NP_001390743.1 histone-lysine N-methyltransferase EZH1 isoform 8
NM_001403816.1 NP_001390745.1 histone-lysine N-methyltransferase EZH1 isoform 10
NM_001403810.1 NP_001390739.1 histone-lysine N-methyltransferase EZH1 isoform 4
NM_001403818.1 NP_001390747.1 histone-lysine N-methyltransferase EZH1 isoform 11
NM_001403813.1 NP_001390742.1 histone-lysine N-methyltransferase EZH1 isoform 7
NM_007970.4 NP_031996.1 histone-lysine N-methyltransferase EZH1 isoform 1

Ezh1 Protein Structure

EZH2_WD-Binding

EZH2_WD-Binding: pfam11616 (41 - 70)

PRC2_HTH_1

PRC2_HTH_1: pfam18118 (161 - 264)

SANT

SANT: cd00167 (435 - 476)

SET

SET: cl34524 (465 - 729)

SET_EZH1

SET_EZH1: cd19217 (610 - 745)

  • 0
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  • 600
  • 750 a.a.
Protein Preferred Names Protein Names

histone-lysine N-methyltransferase EZH1

enhancer of zeste homolog 1

Related Agents

Approval
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-109108 Valemetostat Inhibitor 99.84% Unkown
HY-109108A Valemetostat tosylate Inhibitor 98.14% Unkown
Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-145602 Tulmimetostat Inhibitor 99.79% Phase 2
Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-15646 UNC1999 Inhibitor 99.83% Unkown
HY-144881 (S)-HH2853 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ezh1 NCBI NCBI:2145