Ezh1 - enhancer of zeste 1 polycomb repressive complex 2 subunit Gene

Mus musculus

Also known as ENX-2

Gene ID: 14055 | Gene type: protein coding

About Ezh1

Chromosome 11: 101,081,941-101,117,289 reverse strand.GRCm39:CM001004.3

This gene has 9 transcripts (splice variants), 234 orthologues, 20 paralogues and is associated with 13 phenotypes. Ubiquitous expression in lung adult (RPKM 16.7), kidney adult (RPKM 16.3) and 28 other tissues.

Summary

This gene encodes a member of the Polycomb-group (PcG) family. The encoded protein is interchangeable with the related Enhancer of zeste 2 (EZH2) protein as a core component of the polycomb repressive complex 2 (PRC2), which methylates histone H3 at lysine 27 and results in the transcriptional repression of affected target genes. This complex is involved in carrying out cell-fate decisions during embryonic stem cell differentiation. [provided by RefSeq, Sep 2014]

Ezh1 Products(13)

mRNA	Protein	Name
NM_001403815.1	NP_001390744.1	histone-lysine N-methyltransferase EZH1 isoform 9
NM_001403812.1	NP_001390741.1	histone-lysine N-methyltransferase EZH1 isoform 6
NM_001403811.1	NP_001390740.1	histone-lysine N-methyltransferase EZH1 isoform 5
NM_001403809.1	NP_001390738.1	histone-lysine N-methyltransferase EZH1 isoform 3
NM_001403822.1	NP_001390751.1	histone-lysine N-methyltransferase EZH1 isoform 4
NM_001403807.1	NP_001390736.1	histone-lysine N-methyltransferase EZH1 isoform 2
NM_001403821.1	NP_001390750.1	histone-lysine N-methyltransferase EZH1 isoform 1
NM_001403814.1	NP_001390743.1	histone-lysine N-methyltransferase EZH1 isoform 8
NM_001403816.1	NP_001390745.1	histone-lysine N-methyltransferase EZH1 isoform 10
NM_001403810.1	NP_001390739.1	histone-lysine N-methyltransferase EZH1 isoform 4
NM_001403818.1	NP_001390747.1	histone-lysine N-methyltransferase EZH1 isoform 11
NM_001403813.1	NP_001390742.1	histone-lysine N-methyltransferase EZH1 isoform 7
NM_007970.4	NP_031996.1	histone-lysine N-methyltransferase EZH1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
NOT enables DNA binding	IDA IDA: Inferred from direct assay	19026781	MGI
enables histone H3K27 methyltransferase activity	IDA IDA: Inferred from direct assay	19303854	MGI
contributes to histone binding	IDA IDA: Inferred from direct assay	19026781	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9584197	MGI
enables transcription corepressor activity	IDA IDA: Inferred from direct assay	19026781	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in chromatin remodeling	IDA IDA: Inferred from direct assay	19026781	MGI
involved in facultative heterochromatin formation	IDA IDA: Inferred from direct assay	20064376	MGI
acts upstream of or within hepatocyte homeostasis	IGI IGI: Inferred from genetic interaction	25477280	MGI
involved in heterochromatin formation	IDA IDA: Inferred from direct assay	19026781	MGI
acts upstream of or within liver regeneration	IGI IGI: Inferred from genetic interaction	25477280	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19026781	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	19303854	MGI
acts upstream of or within response to tetrachloromethane	IGI IGI: Inferred from genetic interaction	25477280	MGI
involved in subtelomeric heterochromatin formation	IGI IGI: Inferred from genetic interaction	9214638	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of ESC/E(Z) complex	IDA IDA: Inferred from direct assay	19026781	MGI
located in chromosome, telomeric region	IGI IGI: Inferred from genetic interaction	9214638	MGI
located in heterochromatin	IDA IDA: Inferred from direct assay	19026781	MGI
located in nucleus	IDA IDA: Inferred from direct assay	9584197	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ezh1 Protein Structure

EZH2_WD-Binding

PRC2_HTH_1

SANT

SET

SET_EZH1

0
200
400
600
750 a.a.

Protein Preferred Names

Protein Names

histone-lysine N-methyltransferase EZH1

enhancer of zeste homolog 1

Ezh1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Ezh1	P70351	Mtf2	Mus musculus	Q02395	Anti Tag CoIP	20064376
Intra	Ezh1	P70351	Jarid2	Mus musculus	Q62315	Anti Tag CoIP	20064376

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-109108	Valemetostat	Inhibitor	99.84%	Unkown
HY-109108A	Valemetostat tosylate	Inhibitor	98.14%	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-145602	Tulmimetostat	Inhibitor	99.79%	Phase 2

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15646	UNC1999	Inhibitor	99.83%	Unkown
HY-144881	(S)-HH2853	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ezh1	NCBI	NCBI:2145

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