2. PROTAC Epigenetics
  3. PROTACs Histone Methyltransferase
  4. MS4322 (isomer)

MS4322 (isomer)  (Synonyms: YS43-22 (isomer))

Cat. No.: HY-141877B Purity: 99.22%
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Handling Instructions Technical Support

MS4322 (YS43-22) isomer is an isomer of MS4322. MS4322 is a specific PRMT5 PROTAC degrader. MS4322 reduces the PRMT5 protein level with a DC50 of 1.1 μM in MCF-7 cells. MS4322 inhibits the methyltransferase activity of PRMT5 with an IC50 of 18 nM. MS4322 promotes ubiquitination and degradation of PRMT5. MS4322 can be used for the research of breast cancer, lung cancer, and hepatocellular cancer. (Pink: PRMT5 ligand (HY-173092); Blue: E3 ligase ligand HY-112078); Black: linker (HY-124780); E3+linker (HY-173093 )).

For research use only. We do not sell to patients.

MS4322 (isomer) Chemical Structure

MS4322 (isomer) Chemical Structure

CAS No. : 2601727-80-2

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Based on 1 publication(s) in Google Scholar

Other Forms of MS4322 (isomer):

MS4322 (isomer) Related Antibodies

Top Publications Citing Use of Products

View All PROTACs Isoform Specific Products:

View All Isoforms
von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

View All Histone Methyltransferase Isoform Specific Products:

View All Isoforms
EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

MS4322 (YS43-22) isomer is an isomer of MS4322. MS4322 is a specific PRMT5 PROTAC degrader. MS4322 reduces the PRMT5 protein level with a DC50 of 1.1 μM in MCF-7 cells. MS4322 inhibits the methyltransferase activity of PRMT5 with an IC50 of 18 nM. MS4322 promotes ubiquitination and degradation of PRMT5. MS4322 can be used for the research of breast cancer, lung cancer, and hepatocellular cancer. (Pink: PRMT5 ligand (HY-173092); Blue: E3 ligase ligand HY-112078); Black: linker (HY-124780); E3+linker (HY-173093 ))[1].
IC50 & Target[1]

VHL

 

Cereblon

 

MDM2

 

SMYD2

 

SMYD3

 

EHMTI PEP

 

SETD7/KMT7

 

PRMT4

 

PRMT8

 

EZH1

 

SETDB1/KMT2G

 

SETD8/KMT5A

 

PRMT5

 

EZH2

 

SUV39H2/KMT1B

 

SETD2/KMT3A

 

PRMT1

 

PRMT6

 

DOT1L

 

EHMT2/G9a/KMT1C

 

NSD2

 

PRMT3

 

PRMT7

 

Molecular Weight

1101.32

Formula

C55H76N10O12S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N1CC(C1)NC2=NC=NC(C(NC[C@H](O)CN3CC4=CC=CC=C4CC3)=O)=C2)COCCOCCOCCOCCOCC(N[C@H](C(C)(C)C)C(N5[C@@H](C[C@H](C5)O)C(N[C@@H](C6=CC=C(C7=C(C)N=CS7)C=C6)C)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (45.40 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9080 mL 4.5400 mL 9.0800 mL
5 mM 0.1816 mL 0.9080 mL 1.8160 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.9080 mL 4.5400 mL 9.0800 mL 22.7000 mL
5 mM 0.1816 mL 0.9080 mL 1.8160 mL 4.5400 mL
10 mM 0.0908 mL 0.4540 mL 0.9080 mL 2.2700 mL
15 mM 0.0605 mL 0.3027 mL 0.6053 mL 1.5133 mL
20 mM 0.0454 mL 0.2270 mL 0.4540 mL 1.1350 mL
25 mM 0.0363 mL 0.1816 mL 0.3632 mL 0.9080 mL
30 mM 0.0303 mL 0.1513 mL 0.3027 mL 0.7567 mL
40 mM 0.0227 mL 0.1135 mL 0.2270 mL 0.5675 mL
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MS4322 (isomer) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MS4322 (isomer)2601727-80-2YS43-22 (isomer)PROTACsHistone Methyltransferaseinhibit growth of multiple cancer cellsInhibitorinhibitorinhibit

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