2. Gene
  3. Bmpr2 - bone morphogenetic protein receptor type 2 Gene

Bmpr2 - bone morphogenetic protein receptor type 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Bmpr-II

Gene ID: 140590 | Gene type: protein coding

About Bmpr2

Primary_assembly 9: 61,190,566-61,301,809 forward strand.mRatBN7.2:CM026982.1

This gene has 2 transcripts (splice variants), 265 orthologues, 11 paralogues and is associated with 24 phenotypes. Biased expression in Lung (RPKM 976.5), Heart (RPKM 288.5) and 8 other tissues.

Summary

Enables growth factor binding activity. Involved in brain development and retina development in camera-type eye. Located in several cellular components, including apical plasma membrane; basal plasma membrane; and caveola. Used to study pulmonary hypertension. Biomarker of pulmonary hypertension. Human ortholog(s) of this gene implicated in heart septal defect; primary pulmonary hypertension; pulmonary hypertension; and pulmonary venoocclusive disease. Orthologous to human BMPR2 (bone morphogenetic protein receptor type 2). [provided by Alliance of Genome Resources, Apr 2022]

Bmpr2 Products(1)

mRNA Protein Name
NM_080407.1 NP_536332.1 bone morphogenetic protein receptor type-2 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables growth factor binding IDA
IDA: Inferred from direct assay
11044210 RGD
Biological Process GO Annotation Evidence Reference Source
involved in retina development in camera-type eye IEP
IEP: Inferred from expression pattern
10482474 RGD
Cellular Component GO Annotation Evidence Reference Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
16271518 RGD
located in basal plasma membrane IDA
IDA: Inferred from direct assay
16271518 RGD
located in caveola IDA
IDA: Inferred from direct assay
16271518 RGD
located in dendrite IDA
IDA: Inferred from direct assay
21185359 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
21185359 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Bmpr2 Protein Structure

Activin_recp

Activin_recp: pfam01064 (59 - 140)

STKc_BMPR2_AMHR2

STKc_BMPR2_AMHR2: cd14054 (220 - 517)

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  • 1052 a.a.
Protein Preferred Names Protein Names

bone morphogenetic protein receptor type-2

bone morphogenetic protein receptor type II

bone morphogenetic protein receptor, type II (serine/threonine kinase)

bone morphogenic protein receptor, type II (serine/threonine kinase)

Related Agents

Pre-clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-15897 LDN-212854 Inhibitor 99.70% Unkown
HY-154970A BMPR2-IN-1 TFA Inhibitor 99.40% Unkown
HY-154970 BMPR2-IN-1 Inhibitor / Unkown
HY-164145 CDD-1653 / Unkown
HY-RS01552 BMPR2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS01553 Bmpr2 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS01554 Bmpr2 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bmpr2 NCBI NCBI:659