BPIFA2 - BPI fold containing family A member 2 Gene

Homo sapiens

Also known as PSP; SPLUNC2; C20orf70; bA49G10.1

Gene ID: 140683 | Gene type: protein coding

About BPIFA2

This gene has 2 transcripts (splice variants), 89 orthologues and 12 paralogues. Restricted expression toward salivary gland (RPKM 1129.7).

Summary

This gene encodes a member of the palate, lung and nasal epithelium clone (Plunc) family of proteins. Members of this family have been proposed to play a role in the local Antibacterial response in nose, mouth and upper respiratory pathways. The encoded soluble salivary protein binds Bacterial lipopolysaccharide (LPS) and inhibits Bacterial growth. This gene is present in a gene cluster on chromosome 20. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

BPIFA2 Products(2)

mRNA	Protein	Name
NM_001319164.2	NP_001306093.1	BPI fold-containing family A member 2 precursor
NM_080574.4	NP_542141.1	BPI fold-containing family A member 2 precursor

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables lipopolysaccharide binding	IDA IDA: Inferred from direct assay	21833535	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular region	IDA IDA: Inferred from direct assay	19499239	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	28775000	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BPIFA2 Protein Structure

LBP_BPI_CETP

0
100
200
249 a.a.

Protein Preferred Names

Protein Names

BPI fold-containing family A member 2

parotid secretory protein

BPIFA2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	BPIFA2	Q96DR5	CMTM6	Homo sapiens	Q9NX76	Y2H Array	32296183
Intra	BPIFA2	Q96DR5	CMTM6	Homo sapiens	Q9NX76	Y2H Prey Pooling	32296183
Intra	BPIFA2	Q96DR5	CMTM6	Homo sapiens	Q9NX76	Validated Y2H	32296183
Intra	BPIFA2	Q96DR5	AGTRAP	Homo sapiens	Q6RW13-2	Y2H Prey Pooling	32296183
Intra	BPIFA2	Q96DR5	AGTRAP	Homo sapiens	Q6RW13-2	Y2H Array	32296183
Intra	BPIFA2	Q96DR5	AGTRAP	Homo sapiens	Q6RW13	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant BPIFA2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76749	BPIFA2 Protein, Human (HEK293, Fc)	Q96DR5 (E19-I249)	≥95%
HY-P76750	BPIFA2 Protein, Human (HEK293, His)	Q96DR5 (E19-I249)	≥95%

Related Diseases

Diseases

Alias

Papillary Cystadenocarcinoma

Cystadenocarcinoma, Papillary

Xerophthalmia

Conjunctival Xerosis

Parotid Disease

Parotid Diseases

Lacrimal Apparatus Disease

Lacrimal Apparatus Diseases

Filamentary Keratitis

Sialadenitis

Sialoadenitis	Adenitis, Salivary Gland
Salivary Gland Inflammation	Salivary Gland Adenitis
Sialitis	Inflammation Of Salivary Gland
Inflammation Of Salivary Duct Or Gland	Salivary Glandular Adenitis
Sialoangiitis	Sialoangitis
Sialodochitis

Parotitis

Dry Eye Syndrome

Dry Eye Syndromes	Dry Eye Disease
Tear Film Insufficiency	Xerophthalmia

Lagophthalmos

Defective Lid Closure

Poor Closure Eyelids

Keratoconjunctivitis Sicca

Kcs	Dry Eye Syndromes
Keratitis Sicca	Xerophthalmia

Dacryoadenitis

Dacryocystitis

Autoimmune Disease Of Exocrine System

Potocki-Shaffer Syndrome

Proximal 11p Deletion Syndrome	Chromosome 11p11.2 Deletion Syndrome
Pss	11p11.2 Deletion
P11pds	Defect11 Syndrome
Deletion Of Chromosome 11p11.2	POSHS

Salivary Gland Disease

Salivary Gland Disorders	Salivary Gland Diseases
Non-Neoplastic Salivary Gland Disease	Non-Neoplastic Salivary Gland Disorder
Disorder Of Salivary Gland	Lesion Of Salivary Gland Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01582	BPIFA2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	BPIFA2	VGNC	VGNC:107773
Rattus norvegicus	BPIFA2	RGD	RGD:3431
Mus musculus	BPIFA2	MGD	MGI:97787
Canis familiaris	BPIFA2	VGNC	VGNC:38505
Others	BPIFA2	NCBI

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