CRY1 - cryptochrome circadian regulator 1 Gene

Homo sapiens

Also known as DSPD; PHLL1

Gene ID: 1407 | Gene type: protein coding

About CRY1

Cytogenetic location: 12q23.3 Genomic coordinates (GRCh38): 12:106,991,364-107,093,549 (from NCBI)

This gene has 5 transcripts (splice variants), 262 orthologues, 1 paralogue and is associated with 1 phenotype. Broad expression in testis (RPKM 23.5), thyroid (RPKM 10.6) and 25 other tissues.

Summary

This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across Plants and Animals. Loss of the related gene in mouse results in a shortened circadian cycle in complete darkness. [provided by RefSeq, Jan 2014]

CRY1 Products(14)

mRNA	Protein	Name
NM_001413458.1	NP_001400387.1	cryptochrome-1 isoform a
NM_001413459.1	NP_001400388.1	cryptochrome-1 isoform b
NM_001413460.1	NP_001400389.1	cryptochrome-1 isoform c
NM_001413461.1	NP_001400390.1	cryptochrome-1 isoform d
NM_001413462.1	NP_001400391.1	cryptochrome-1 isoform d
NM_001413463.1	NP_001400392.1	cryptochrome-1 isoform e
NM_001413464.1	NP_001400393.1	cryptochrome-1 isoform f
NM_001413465.1	NP_001400394.1	cryptochrome-1 isoform f
NM_001413466.1	NP_001400395.1	cryptochrome-1 isoform g
NM_001413467.1	NP_001400396.1	cryptochrome-1 isoform h
NM_001413468.1	NP_001400397.1	cryptochrome-1 isoform h
NM_001413469.1	NP_001400398.1	cryptochrome-1 isoform h
NM_001413470.1	NP_001400399.1	cryptochrome-1 isoform h
NM_004075.5	NP_004066.1	cryptochrome-1 isoform d

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
NOT enables DNA (6-4) photolyase activity	IDA IDA: Inferred from direct assay	8909283	GOA
NOT enables deoxyribodipyrimidine photo-lyase activity	IDA IDA: Inferred from direct assay	8909283	GOA
enables double-stranded DNA binding	IDA IDA: Inferred from direct assay	9801304	GOA
enables nuclear receptor binding	IPI IPI: Inferred from physical interaction	22170608	GOA
enables phosphatase binding	IPI IPI: Inferred from physical interaction	9383998	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9383998	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12397359	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12397359	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	26431207	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CRY1 Protein Structure

DNA_photolyase

FAD_binding_7

0
100
200
300
400
500
586 a.a.

Protein Preferred Names

Protein Names

cryptochrome-1

cryptochrome 1 (photolyase-like)

Related Diseases

Diseases

Alias

Delayed Sleep Phase Disorder

Delayed Sleep Phase Syndrome	Delayed Sleep Phase Syndrome, Susceptibility To
DSPD	Delayed Sleep Phase Disorder, Susceptibility To
DSPS	Sleep Phase, Delayed, Disorder
Sleep Phase Syndrome, Delayed, Susceptibility To

Sleep Disorder

Sleep Disorders

Non-Organic Sleep Disorder

Advanced Sleep Phase Syndrome

Fasps	Familial Advanced Sleep-Phase Syndrome
Advanced Sleep Phase Syndrome, Familial	Familial Advanced Sleep Phase Syndrome
Sleep Phase Syndrome, Advanced, Familial	Advanced Sleep-Phase Syndrome, Familial

Sleep Apnea

Sleep Apnea Syndromes

Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder	ADHD
Attention Deficit Disorder	Attention Deficit-Hyperactivity Disorder, Susceptibility To
Attention Deficit Disorder With Hyperactivity	Hyperkinetic Disorder
Hyperactivity Of Childhood	Attention-Deficit/Hyperactivity Disorder
Add	Addh
Attention Deficit	Attention Deficit Disorder Of Childhood With Hyperactivity
Attention Deficit Disorder With Hyperactivity Syndrome	Hyperkinetic Syndrome
Attention-Deficit Hyperactivity Disorder	Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type
Disturbance Of Activity And Attention	Disorder Of Activity And Attention
Adhd - [Attention Deficit Hyperactivity Disorder]	Hyperkinetic Disorders
Disorder Of Activity And Attention With Hyperkinesia	Attention Deficit Syndrome With Hyperactivity

Major Depressive Disorder

Seasonal Affective Disorder	Unipolar Depression
Depression	MDD
Depressive Disorder	Unipolar Depression, Susceptibility To
Major Depressive Disorder 1	Major Depressive Disorder, Response To Citalopram Therapy In
Major Depressive Disorder 2	Winter Depression
Single Major Depressive Episode	Sad
Clinical Depression	Major Depression
Depressive Syndrome	Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment
Seasonal Affective Disorder, Susceptibility To	Recurrent Major Depression
Affective Disorder, Seasonal	Depression In A Seasonal Pattern
Depression	Seasonal
Major Depressive Disorder With A Seasonal Pattern	Seasonal Depression
Seasonal Mood Disorder	Mental Depression
Recurrent Major Depressive Episodes

Bipolar Disorder

Bipolar Depression	Manic Disorder
Depression, Bipolar	Bipolar Disorder Manic Phase
Depressive-Manic Psych.	Manic Bipolar Affective Disorder
Manic Bipolar I Disorder	Manic Depression
Manic Depressive Disorder	Mixed Bipolar Disorder
Bipolar Affective Disorder	Bipolar Affective Psychosis
Bipolar Spectrum Disorder	Manic Depressive Illness
Depression Bipolar	Bipolar Disorder, Mixed
Major Affective Disorder	Major Affective Disorder 1
Major Affective Disorder 2

Apnea, Obstructive Sleep

Obstructive Sleep Apnea Syndrome	Obstructive Sleep Apnea
Sleep Apnea, Obstructive	Osa
Osas	Sleep Apnea/Hypopnea Syndrome
Sahs	Upper Airway Resistance Sleep Apnea Syndrome
Apnea, Obstructive	Obstructive Apnea
Osahs	Sleep Apnea Hypopnea Syndrome
Sleep Apnea Syndrome, Obstructive	Sleep Apnea Obstructive
Sleep Apnea Syndromes	Obstructive Sleep Apnoea Syndrome
Obstructive Sleep Apnoea, Adult	Osa - [Obstructive Sleep Apnoea]
Obstructive Sleep Apnoea, Paediatric	Obstructive Sleep Apnoea Hypopnoea Syndrome
Osa Syndrome	Sleep Apnoea Nos
[Sas] - Sleep Apnoea Syndrome	Sleep Apnoea Syndrome
[Osahs] - Obstructive Sleep Apnoea-Hypopnea Syndrome	[Sahs] - Sleep Apnoea-Hypopnea Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-108468	KL001		99.68%	Phase 1

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-115672	KS15		99.40%	Unkown
HY-134194	KL201		98.15%	Unkown
HY-148764	M47	Inducer	99.90%	Unkown
HY-RS03204	CRY1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CRY1	VGNC	VGNC:71499
Bos taurus	CRY1	VGNC	VGNC:27730
Felis catus	CRY1	VGNC	VGNC:61195
Canis familiaris	CRY1	VGNC	VGNC:39633
Mus musculus	CRY1	MGD	MGI:1270841
Rattus norvegicus	CRY1	RGD	RGD:735083

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