SUN5 - Sad1 and UNC84 domain containing 5 Gene

Homo sapiens

Also known as SPAG4L; SPGF16; TSARG4; dJ726C3.1

Gene ID: 140732 | Gene type: protein coding

About SUN5

Cytogenetic location: 20q11.21 Genomic coordinates (GRCh38): 20:32,983,775-33,004,433 (from NCBI)

This gene has 4 transcripts (splice variants), 137 orthologues, 4 paralogues and is associated with 2 phenotypes. Restricted expression toward testis (RPKM 7.9).

Summary

The protein encoded by this gene appears to play a role in the meiotic stage of spermatogenesis. The encoded protein localizes to the junction between the sperm head and body and may be involved in nuclear envelope reconstitution and nuclear migration. Mutations in this gene have been implicated in acephalic spermatozoa syndrome. [provided by RefSeq, May 2017]

SUN5 Products(1)

mRNA	Protein	Name
NM_080675.4	NP_542406.2	SUN domain-containing protein 5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in spermatogenesis	IEP IEP: Inferred from expression pattern	12621555	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nuclear inner membrane	IDA IDA: Inferred from direct assay	27640305	GOA
located in sperm head-tail coupling apparatus	IDA IDA: Inferred from direct assay	27640305	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SUN5 Protein Structure

Sad1_UNC

0
100
200
300
379 a.a.

Protein Preferred Names

Protein Names

SUN domain-containing protein 5

epididymis secretory sperm binding protein

SUN5 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SUN5	Q8TC36	SPAG4	Homo sapiens	Q9NPE6	Y2H Array	32296183
Intra	SUN5	Q8TC36	SPAG4	Homo sapiens	Q9NPE6	Y2H Prey Pooling	32296183
Intra	SUN5	Q8TC36	SPAG4	Homo sapiens	Q9NPE6	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Spermatogenic Failure 16

SPGF16	Acephalic Spermatozoa Syndrome
Spermatozoa, Acephalic

Male Infertility Due To Acephalic Spermatozoa

Acephalic Spermatozoa Syndrome

Spermatogenic Failure 9

Male Infertility Due To Globozoospermia	SPGF9
Male Infertility Due To Round-Headed Spermatozoa	Globozoospermia, Complete
Globozoospermia, Total	Globozoospermia
Globozoospermia Syndrome	Round-Headed Sperm Syndrome
Globozoospermia Complete	Globozoospermia Total

Spermatogenic Failure

Azoospermia	Spgf
Spermatogenic Failure, Susceptibility To	Absent Sperm
Aspermatogenesis	Infertility Due To Azoospermia
Hypospermatogenesis	Azoospermatism

Infertility

Spermatogenic Failure 14

SPGF14

Spermatogenic Failure 15

SPGF15

Spermatogenic Failure, 15

Oligoasthenoteratozoospermia

Oat	Oligoasthenoteratospermia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14032	SUN5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SUN5	RGD	RGD:1306357
Canis familiaris	SUN5	VGNC	VGNC:46987
Bos taurus	SUN5	VGNC	VGNC:35476
Felis catus	SUN5	VGNC	VGNC:65844
Mus musculus	SUN5	MGD	MGI:1923657
Macaca mulatta	SUN5	VGNC	VGNC:78133

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