Ccn2 - cellular communication network factor 2 Gene

Mus musculus

Also known as Ctgf; Hcs24; Fisp12; fisp-12

Gene ID: 14219 | Gene type: protein coding

About Ccn2

Summary

Enables heparin binding activity and Integrin binding activity. Acts upstream of or within several processes, including cartilage condensation; cell surface receptor signaling pathway; and chondrocyte proliferation. Located in extracellular matrix and extracellular region. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; sensory organ; and skeleton. Orthologous to human CCN2 (cellular communication network factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Ccn2 Products(1)

mRNA	Protein	Name
NM_010217.2	NP_034347.2	CCN family member 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables heparin binding	IDA IDA: Inferred from direct assay	9184077	MGI
enables integrin binding	IDA IDA: Inferred from direct assay	10446209	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within angiogenesis	IDA IDA: Inferred from direct assay	10082563	MGI
acts upstream of or within angiogenesis	IMP IMP: Inferred from mutant phenotype	12736220	MGI
acts upstream of or within cartilage condensation	IDA IDA: Inferred from direct assay	15305294	MGI
acts upstream of or within cell migration	IDA IDA: Inferred from direct assay	10082563	MGI
acts upstream of or within cell-matrix adhesion	IDA IDA: Inferred from direct assay	9184077	MGI
acts upstream of or within chondrocyte differentiation	IDA IDA: Inferred from direct assay	15305294	MGI
acts upstream of or within chondrocyte proliferation	IMP IMP: Inferred from mutant phenotype	18597638	MGI
acts upstream of or within connective tissue development	IMP IMP: Inferred from mutant phenotype	23839921	MGI
acts upstream of or within fibroblast growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	9184077	MGI
acts upstream of or within integrin-mediated signaling pathway	IDA IDA: Inferred from direct assay	10082563	MGI
acts upstream of or within lung development	IMP IMP: Inferred from mutant phenotype	18213577	MGI
acts upstream of or within negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	18597638	MGI
acts upstream of or within ossification	IMP IMP: Inferred from mutant phenotype	11237711	MGI
acts upstream of or within reactive oxygen species metabolic process	IDA IDA: Inferred from direct assay	19364818	MGI
acts upstream of or within regulation of chondrocyte differentiation	IMP IMP: Inferred from mutant phenotype	18597638	MGI
acts upstream of or within tissue homeostasis	IMP IMP: Inferred from mutant phenotype	23839921	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular matrix	IDA IDA: Inferred from direct assay	9184077	MGI
located in extracellular region	IDA IDA: Inferred from direct assay	1888698	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

CCN family member 2

Connective tissue growth factor precursor (CTGF) (FISP-12 protein) (Hypertrophic chondrocyte-specific protein 24)	cellular communication network factor 1
fibroblast inducible secreated protein	fibroblast inducible secreted protein
hypertrophic chondro

Recombinant Ccn2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72154	CCN2/CTGF Protein, Mouse (GST)	P29268 (Q26-Y344)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P5314	OK2	Inhibitor	95.95%	Unkown
HY-RS02111	CCN2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ccn2	NCBI	NCBI:1490
Rattus norvegicus	Ccn2	NCBI	NCBI:64032
Macaca mulatta	Ccn2	NCBI	NCBI:714520

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