Ccn2 - cellular communication network factor 2 Gene

Rattus norvegicus

Also known as Ctgf; CTGRP

Gene ID: 64032 | Gene type: protein coding

About Ccn2

Summary

Enables fibronectin binding activity and growth factor activity. Involved in several processes, including positive regulation of G0 to G1 transition; positive regulation of collagen biosynthetic process; and positive regulation of macromolecule metabolic process. Located in several cellular components, including cell cortex; cis-Golgi network; and perinuclear region of cytoplasm. Used to study endomyocardial fibrosis. Biomarker of several diseases, including artery disease (multiple); lung disease (multiple); membranoproliferative glomerulonephritis; primary biliary cholangitis; and restrictive cardiomyopathy (multiple). Orthologous to human CCN2 (cellular communication network factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Ccn2 Products(1)

mRNA	Protein	Name
NM_022266.2	NP_071602.1	CCN family member 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables fibronectin binding	IDA IDA: Inferred from direct assay	18167060	RGD
enables growth factor activity	IDA IDA: Inferred from direct assay	10026205	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in calcium ion transmembrane import into cytosol	IMP IMP: Inferred from mutant phenotype	19707545	RGD
involved in cellular response to fatty acid	IEP IEP: Inferred from expression pattern	19625611	RGD
involved in cellular response to glucose stimulus	IEP IEP: Inferred from expression pattern	19625611	RGD
involved in cellular response to interleukin-13	IEP IEP: Inferred from expression pattern	21804025	RGD
involved in extracellular matrix constituent secretion	IMP IMP: Inferred from mutant phenotype	18613219	RGD
involved in intracellular signal transduction	IDA IDA: Inferred from direct assay	12193543	RGD
involved in lung development	IEP IEP: Inferred from expression pattern	19361631	RGD
involved in microtubule depolymerization	IMP IMP: Inferred from mutant phenotype	20858895	RGD
involved in positive regulation of G0 to G1 transition	IMP IMP: Inferred from mutant phenotype	18613219	RGD
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	19625611	RGD
involved in positive regulation of cardiac muscle contraction	IMP IMP: Inferred from mutant phenotype	19707545	RGD
involved in positive regulation of cell activation	IMP IMP: Inferred from mutant phenotype	18613219	RGD
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	19570811	RGD
involved in positive regulation of collagen biosynthetic process	IMP IMP: Inferred from mutant phenotype	19570811	RGD
involved in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	19625611	RGD
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	19570811	RGD
involved in positive regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	19707545	RGD
involved in response to amino acid	IEP IEP: Inferred from expression pattern	17250813	RGD
involved in response to anoxia	IEP IEP: Inferred from expression pattern	18929865	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	19509476	RGD
involved in response to fatty acid	IEP IEP: Inferred from expression pattern	19656915	RGD
involved in response to mineralocorticoid	IEP IEP: Inferred from expression pattern	19521108	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	19558898	RGD
involved in response to peptide hormone	IEP IEP: Inferred from expression pattern	19667256	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell cortex	IDA IDA: Inferred from direct assay	19359517	RGD
located in extracellular space	IDA IDA: Inferred from direct assay	19570811	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	19359517	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

CCN family member 2

connective tissue growth factor

connective tissue growth-related protein

Recombinant Ccn2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P79369	CCN2/CTGF Protein, Rat (HEK293)	Q9R1E9 (Q25-A347)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P5314	OK2	Inhibitor	95.95%	Unkown
HY-RS02111	CCN2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ccn2	NCBI	NCBI:1490
Mus musculus	Ccn2	NCBI	NCBI:14219
Macaca mulatta	Ccn2	NCBI	NCBI:714520

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