Tlr3 - toll-like receptor 3 Gene

Mus musculus

Gene ID: 142980 | Gene type: protein coding

About Tlr3

Chromosome 8: 45,848,702-45,864,117 reverse strand.GRCm39:CM001001.3

This gene has 9 transcripts (splice variants), 156 orthologues, 23 paralogues and is associated with 50 phenotypes. Broad expression in bladder adult (RPKM 3.5), large intestine adult (RPKM 1.7) and 25 other tissues.

Summary

Predicted to enable double-stranded RNA binding activity; identical protein binding activity; and signaling receptor activity. Involved in several processes, including JNK cascade; positive regulation of angiogenesis; and positive regulation of cytokine production. Acts upstream of or within several processes, including positive regulation of NF-kappaB transcription factor activity; positive regulation of intracellular signal transduction; and regulation of cytokine production. Predicted to be located in cell surface and cytoplasm. Predicted to be integral component of plasma membrane. Is expressed in brain; cerebral cortex; cerebral cortex ventricular layer; forebrain; and submandibular gland primordium. Human ortholog(s) of this gene implicated in several diseases, including hepatitis B; hepatitis C; human immunodeficiency virus infectious disease; liver cirrhosis; and type 1 diabetes mellitus. Orthologous to human TLR3 (toll like receptor 3). [provided by Alliance of Genome Resources, Apr 2022]

Tlr3 Products(3)

mRNA	Protein	Name
NM_126166.5	NP_569054.2	toll-like receptor 3 precursor
NM_001357317.1	NP_001344246.1	toll-like receptor 3 precursor
NM_001357316.1	NP_001344245.1	toll-like receptor 3 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables pattern recognition receptor activity	IDA IDA: Inferred from direct assay	16260493	MGI
enables pattern recognition receptor activity	IGI IGI: Inferred from genetic interaction	16260493	MGI
enables pattern recognition receptor activity	IMP IMP: Inferred from mutant phenotype	12855817	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	17452530	MGI
enables transmembrane signaling receptor activity	IDA IDA: Inferred from direct assay	27830702	MGI
enables ubiquitin-like protein ligase binding	IPI IPI: Inferred from physical interaction	31076723	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of JNK cascade	IDA IDA: Inferred from direct assay	16260493	MGI
involved in JNK cascade	IMP IMP: Inferred from mutant phenotype	18802055	MGI
involved in MAPK cascade	IMP IMP: Inferred from mutant phenotype	18802055	MGI
acts upstream of or within cellular response to exogenous dsRNA	IDA IDA: Inferred from direct assay	28970238	MGI
involved in cellular response to virus	IMP IMP: Inferred from mutant phenotype	18802055	MGI
acts upstream of chemokine production	IMP IMP: Inferred from mutant phenotype	12855817	MGI
acts upstream of or within defense response	IMP IMP: Inferred from mutant phenotype	11607032	MGI
acts upstream of or within defense response to virus	IGI IGI: Inferred from genetic interaction	18250457	MGI
involved in inflammatory response to wounding	IDA IDA: Inferred from direct assay	27830702	MGI
acts upstream of interleukin-6 production	IDA IDA: Inferred from direct assay	18261938	MGI
acts upstream of macrophage cytokine production	IDA IDA: Inferred from direct assay	18261938	MGI
acts upstream of macrophage cytokine production	IMP IMP: Inferred from mutant phenotype	12855817	MGI
acts upstream of or within positive regulation of JNK cascade	IDA IDA: Inferred from direct assay	16260493	MGI
involved in positive regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	12855817	MGI
involved in positive regulation of angiogenesis	IGI IGI: Inferred from genetic interaction	26934179	MGI
acts upstream of or within positive regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	19734906	MGI
involved in positive regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	16260493	MGI
involved in positive regulation of canonical NF-kappaB signal transduction	IGI IGI: Inferred from genetic interaction	16260493	MGI
involved in positive regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	12855817	MGI
acts upstream of or within positive regulation of chemokine production	IMP IMP: Inferred from mutant phenotype	12855817	MGI
involved in positive regulation of cytokine production involved in inflammatory response	IDA IDA: Inferred from direct assay	27830702	MGI
involved in positive regulation of interferon-beta production	IDA IDA: Inferred from direct assay	15356140	MGI
involved in positive regulation of interleukin-12 production	IDA IDA: Inferred from direct assay	15356140	MGI
acts upstream of or within positive regulation of interleukin-6 production	IDA IDA: Inferred from direct assay	18261938	MGI
involved in positive regulation of interleukin-6 production	IDA IDA: Inferred from direct assay	15356140	MGI
acts upstream of or within positive regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	17008311	MGI
acts upstream of or within positive regulation of macrophage cytokine production	IDA IDA: Inferred from direct assay	18261938	MGI
acts upstream of or within positive regulation of macrophage cytokine production	IMP IMP: Inferred from mutant phenotype	12855817	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15356140	MGI
involved in positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	18802055	MGI
involved in positive regulation of tumor necrosis factor production	IDA IDA: Inferred from direct assay	15356140	MGI
acts upstream of or within positive regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	17008311	MGI
acts upstream of or within positive regulation of type I interferon production	IDA IDA: Inferred from direct assay	18207576	MGI
acts upstream of or within positive regulation of type III interferon production	IDA IDA: Inferred from direct assay	18207576	MGI
acts upstream of or within regulation of dendritic cell cytokine production	IDA IDA: Inferred from direct assay	19047410	MGI
acts upstream of or within response to exogenous dsRNA	IMP IMP: Inferred from mutant phenotype	12855817	MGI
acts upstream of or within response to virus	IMP IMP: Inferred from mutant phenotype	14993594	MGI
acts upstream of type I interferon production	IDA IDA: Inferred from direct assay	18207576	MGI
acts upstream of type III interferon production	IDA IDA: Inferred from direct assay	18207576	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in plasma membrane	IDA IDA: Inferred from direct assay	27830702	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Tlr3 Protein Structure

LRR_RI

PLN00113

LRR_RI

PPP1R42

LRR_RI

LRR_1

LRR_RI

LRRCT

Tlr3_TMD

TIR

0
200
400
600
800
905 a.a.

Protein Preferred Names

Protein Names

toll-like receptor 3

Recombinant Tlr3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73587	TLR3 Protein, Mouse (sf9, His)	Q99MB1 (C29-L705)	≥95%
HY-P73588	TLR3 Protein, Mouse (705a.a, HEK293, His)	Q99MB1 (T26-L705)	≥95%
HY-P78362	TLR3 Protein, Mouse (681a.a, HEK293, His)	Q99MB1 (T25-L705)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-108473	CU-CPT 4a	Inhibitor	99.34%	Unkown
HY-135748	Polyinosinic-polycytidylic acid sodium	Agonist	99.40%	Unkown
HY-101929	CU-CPT17e	Agonist	99.00%	Unkown
HY-18325	AN-3485	Inhibitor	95.63%	Unkown
HY-114592	M199	Inhibitor	/	Unkown
HY-134958	Polyinosinic-polycytidylic acid potassium	Agonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tlr3	NCBI	NCBI:7098
Macaca fascicularis	Tlr3	NCBI	NCBI:102138517

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