2. Immunology/Inflammation NF-κB
  3. Toll-like Receptor (TLR) NF-κB Interleukin Related
  4. AN-3485

AN-3485 is a benzoxaborole analogue and an orally active antagonist of the Toll-like pathway. AN-3485 can inhibit TLR-mediated inflammatory cytokine secretion and has significant anti-inflammatory activity. In addition, AN-3485 also has certain anti-tumor activity.

For research use only. We do not sell to patients.

AN-3485 Chemical Structure

AN-3485 Chemical Structure

CAS No. : 1213827-99-6

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 272 In-stock
Solution
10 mM * 1 mL in DMSO USD 286 In-stock
Solid
5 mg USD 260 In-stock
10 mg USD 380 In-stock
25 mg USD 800 In-stock
50 mg USD 1280 In-stock
100 mg USD 2100 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of AN-3485:

AN-3485 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE AN-3485

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TLR3 TLR8 TLR9 TLR2 TLR4 TLR7 TLR1 TLR6

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

AN-3485 is a benzoxaborole analogue and an orally active antagonist of the Toll-like pathway. AN-3485 can inhibit TLR-mediated inflammatory cytokine secretion and has significant anti-inflammatory activity. In addition, AN-3485 also has certain anti-tumor activity[1][2].

IC50 & Target[2]

TLR2

 

TLR3

 

TLR4

 

TLR5

 

IL-1β

 

IL-6

 

In Vitro

AN-3485 (0-72 h) can inhibit the enhanced cell proliferation, migration, and invasion abilities and suppress the NF-κB signaling pathway in H1975 cells treated with PN1-overexpressing exosomes, indicating that it can weaken the promoting effect of PN1 on the malignant phenotypes of lung cancer cells[1].
AN-3485 (0-100 μM; 0-24 h) can inhibit the expression and release of TNF-α, IL-1β, and IL-6 mediated by TLR2, TLR3, TLR4, and TLR5 in PBMCs and isolated monocytes (IC50: 18-580 nM)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AN-3485 Related Antibodies
In Vivo

N-3485 (35 mg/kg; oral administration; twice daily; 20 days) has an ameliorating effect in a Collagen (HY-NP003)-induced murine arthritis model[2].
AN-3485 (0.1-1 mg; topically applied to the ears; twice) can significantly inhibit PMA (HY-18739)-induced contact dermatitis and Oxazolone (HY-126360)-induced delayed-type hypersensitivity in mice, as well as the production of cytokines such as IL-1β and IL-6[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: DBA/1J male mice aged 6-7 weeks old treated collagen (HY-NP003)[2]
Dosage: 35 mg/kg
Administration: Oral administration (p.o.); twice daily for 20 days
Result: Inhibited the rate of disease progression, and the cumulative disease score increased less compared with the vehicle-treated group.
Alleviated joint inflammation and damage, including synovial inflammation, pannus formation, cartilage damage, and bone resorption.
Molecular Weight

289.52

Formula

C14H13BClNO3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

NCC1=CC(Cl)=C(OC2=CC=C(COB3O)C3=C2)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (17.27 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4540 mL 17.2700 mL 34.5399 mL
5 mM 0.6908 mL 3.4540 mL 6.9080 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.4540 mL 17.2700 mL 34.5399 mL 86.3498 mL
5 mM 0.6908 mL 3.4540 mL 6.9080 mL 17.2700 mL
10 mM 0.3454 mL 1.7270 mL 3.4540 mL 8.6350 mL
15 mM 0.2303 mL 1.1513 mL 2.3027 mL 5.7567 mL
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AN-3485 Related Classifications

Keywords:

AN-34851213827-99-6AN3485AN 3485Toll-like Receptor (TLR)NF-κBInterleukin RelatedNuclear factor-κBNuclear factor-kappaBILarthritis model H1975 cellsPBMCsmonocytesInhibitorinhibitorinhibit

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