1. Gene
  2. TLR3 - toll like receptor 3 Gene

TLR3 - toll like receptor 3 Gene

Homo sapiens

Also known as CD283; IIAE2; IMD83

Gene ID: 7098 | Gene type: protein coding

About TLR3

Cytogenetic location: 4q35.1 Genomic coordinates (GRCh38): 4:186,069,156-186,088,073 (from NCBI)

This gene has 9 transcripts (splice variants), 156 orthologues, 22 paralogues and is associated with 3 phenotypes. Ubiquitous expression in duodenum (RPKM 5.4), small intestine (RPKM 5.0) and 24 other tissues.

Summary

The protein encoded by this gene is a member of the Toll-like Receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral Infection, and induces the activation of NF-kappaB and the production of type I interferons. It thus plays a role in host defense against multiple viruses. [provided by RefSeq, Jul 2021]

TLR3 Products(1)

mRNA Protein Name
NM_003265.3 NP_003256.1 toll-like receptor 3 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables double-stranded RNA binding IDA
IDA: Inferred from direct assay
16111635 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
18172197 GOA
enables pattern recognition receptor activity IDA
IDA: Inferred from direct assay
16720699 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16858407 GOA
Biological Process GO Annotation Evidence Reference Source
involved in I-kappaB phosphorylation IDA
IDA: Inferred from direct assay
19740627 GOA
involved in cellular response to mechanical stimulus IEP
IEP: Inferred from expression pattern
19593445 GOA
involved in defense response to virus IEP
IEP: Inferred from expression pattern
32634389 GOA
involved in extrinsic apoptotic signaling pathway IDA
IDA: Inferred from direct assay
21737330 GOA
involved in inflammatory response to wounding IDA
IDA: Inferred from direct assay
27830702 GOA
involved in necroptotic signaling pathway IDA
IDA: Inferred from direct assay
21737330 GOA
involved in positive regulation of JNK cascade IDA
IDA: Inferred from direct assay
27830702 GOA
involved in positive regulation of chemokine production IDA
IDA: Inferred from direct assay
19740627 GOA
involved in positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
23817958 GOA
involved in positive regulation of interferon-alpha production IDA
IDA: Inferred from direct assay
16286015 GOA
involved in positive regulation of interferon-beta production IDA
IDA: Inferred from direct assay
16286015 GOA
involved in positive regulation of interferon-beta production IMP
IMP: Inferred from mutant phenotype
12054664 GOA
involved in positive regulation of interleukin-6 production IDA
IDA: Inferred from direct assay
19740627 GOA
acts upstream of positive regulation of interleukin-8 production IDA
IDA: Inferred from direct assay
17128265 GOA
involved in positive regulation of non-canonical NF-kappaB signal transduction IDA
IDA: Inferred from direct assay
19740627 GOA
involved in positive regulation of type II interferon production IDA
IDA: Inferred from direct assay
16286015 GOA
acts upstream of or within response to exogenous dsRNA IDA
IDA: Inferred from direct assay
21266579 GOA
involved in toll-like receptor 3 signaling pathway IDA
IDA: Inferred from direct assay
17128265 GOA
involved in toll-like receptor signaling pathway IDA
IDA: Inferred from direct assay
18172197 GOA
Cellular Component GO Annotation Evidence Reference Source
NOT located in cell surface IDA
IDA: Inferred from direct assay
19740627 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
19740627 GOA
is active in early endosome IDA
IDA: Inferred from direct assay
17982077 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TLR3 Protein Structure

LRR_8

LRR_8: Leucine rich repeat (51 - 111)

LRR_8

LRR_8: Leucine rich repeat (123 - 183)

LRR_8

LRR_8: Leucine rich repeat (274 - 330)

LRR_8

LRR_8: Leucine rich repeat (408 - 467)

LRR_8

LRR_8: Leucine rich repeat (480 - 542)

LRR_8

LRR_8: Leucine rich repeat (562 - 622)

TIR

TIR: TIR domain (758 - 895)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 904 a.a.
Protein Preferred Names Protein Names

toll-like receptor 3

TLR3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
TLR3 O15455 TLR3 Homo sapiens O15455
Solution Sedimentation
18172197
Intra
TLR3 O15455 TLR3 Homo sapiens O15455
ToxCat
23155421
Intra
TLR3 O15455 MBL2 Homo sapiens P11226
Anti Bait CoIP
24530528
Intra
TLR3 O15455 BLK Homo sapiens P51451
Anti Tag CoIP
33961781
Intra
TLR3 O15455 SRC Homo sapiens P12931
Anti Tag CoIP
16858407
Intra
TLR3 O15455 CHEK2 Homo sapiens O96017
Y2H Array
25640309
Intra
TLR3 O15455 CISD2 Homo sapiens Q8N5K1
Anti Tag CoIP
33961781
Intra
TLR3 O15455 ATP2A3 Homo sapiens Q93084
Anti Tag CoIP
33961781
Intra
TLR3 O15455 TLR3 Homo sapiens O15455
NMR
25217833
Intra
TLR3 O15455 TRIL Homo sapiens Q7L0X0
Anti Bait CoIP
21911501
Intra
TLR3 O15455 TLR3 Homo sapiens O15455
GMS
18172197
Intra
TLR3 O15455 UNC93B1 Homo sapiens Q9H1C4
Anti Tag CoIP
22164301
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Bronchiolitis
Common Cold

Acute Coryza

Acute Nasopharyngitis

Acute Rhinitis

Acute Viral Rhinopharyngitis

Nasopharyngitis - Acute

Nasopharyngitis, Acute

Rhino-Sinusitis

Rhinosinusitis

Common Colds

Acute Infective Rhinitis

Cold

Coryza

Head Cold

Infective Nasopharyngitis

Rhinopharyngitis

Acute Nasal Catarrh

Infective Rhinitis

Acute Nasopharyngeal Catarrh

Infective Nasopharyngitis Nos

Nasopharyngitis Nos

Epipharyngitis

Mucositis Nos

Inflammatory Disease Of Mucous Membrane

Mucosal Inflammation

Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

Genital Herpes

Herpes Genitalis

Genital Herpes Simplex

Venereal Herpes

Virus-Genital Herpes

Paralytic Poliomyelitis

Poliomyelitis, Paralytic

Zika Fever

Zika Virus Infection

Zika Virus Disease

Zika Virus

Zika Virus Fever

Mosquito-Borne Viral Fever, Zika

Ebola Hemorrhagic Fever

Ebola Virus Disease

Viral Hemorrhagic Fever

Hemorrhagic Fever, Ebola

Ehf

Ebola Fever

Ebola

Hemorrhagic Fevers, Viral

Ebola Haemorrhagic Fever

Ebod - [Ebola Disease]

Evd - [Ebola Virus Disease]

Ebola Virus Haemorrhagic Fever

Vhf - [Viral Haemorrhagic Fever] Nos

Viral Haemorrhagic Fever, Not Otherwise Specified

Multiple Sclerosis

MS

Multiple Sclerosis, Susceptibility To

Disseminated Sclerosis

Multiple Sclerosis, Disease Progression, Modifier Of

Insular Sclerosis

Multiple Sclerosis Modifier Of Disease Progression

Multiple Sclerosis, Susceptibility To 1

Multiple Sclerosis, Susceptibility To, 1

Multiple Sclerosis 1

Generalized Multiple Sclerosis

Multiple Sclerosis Variant

Multiple Sclerosis Susceptibility To

Cerebrospinal Sclerosis

Generalised Multiple Sclerosis

Ms - [Multiple Sclerosis]

Disseminated Cerebrospinal Sclerosis

Disseminated Multiple Sclerosis

Disseminated Nervous System Myelosclerosis

Multiple Cerebrospinal Sclerosis

Multiple Combined Sclerosis

Multiple Sclerosis Generalised

Disseminated Brain Sclerosis

Disseminated Spinal Sclerosis

Insular Brain Sclerosis

Miliary Brain Sclerosis

Multiple Combined Sclerosis Of Spinal Cord

Multiple Ascending Sclerosis

Multiple Brain Sclerosis

Multiple Sclerosis Of Brain Stem

Multiple Sclerosis Of The Brain Stem

Multiple Sclerosis Of Cord

Sclérose En Plaques

Plaque Sclerosis

Multiple Sclerosis Of The Spinal Cord

Parasitic Protozoa Infectious Disease

Protozoan Infections

Mastigophora Infectious Disease

Sarcomastigophora Infectious Disease

Bell'S Palsy

Bell Palsy

Facial Nerve Palsy

Facial Palsy

Facial Paralysis

Bell'S Palsy

Antoni'S Palsy

Facial Cranial Nerve Paralysis

Idiopathic Facial Palsy

Refrigeration Palsy

Facial Nerve Paralysis

Seventh Cranial Nerve Paralysis

Face Paralysis Nos

Superficial Basal Cell Carcinoma

Multifocal Superficial Basal Cell Carcinoma

Multicentric Basal Cell Carcinoma

Superficial Multicentric Basal-Cell Carcinoma

Tick-Borne Encephalitis

Siberian Tick-Borne Encephalitis

Encephalitis, Tick-Borne

Central European Encephalitis

Far Eastern Tbe

Russian Spring-Summer Encephalitis

Taiga Encephalitis

West-Siberian Encephalitis

Western European Tick-Borne Encephalitis

Tbe

Encephalitis Tick-Borne

Encephalitis, Central European

Encephalitis, Far Eastern Russian

Herpes Simplex

Herpes Simplex Infections

Herpesvirus Hominis Disease

Herpes Simplex Disease

Herpesviral Infection Due To Herpes Simplex

Infections Due To Simplex Virus

Herpes Nos

Human Immunodeficiency Virus Type 1

Aids

Hiv/Aids

Aids, Delayed/Rapid Progression To

Hiv-1, Susceptibility To

Hiv-1 Viremia, Susceptibility To

Human Immunodeficiency Virus Type 1, Susceptibility To

Hiv-1

Aids, Slow Progression To

Rapid Progression To Aids From Hiv1 Infection

Hiv1 Infection, Resistance To

Hiv1 Infection

Hiv-1 Viremia

Aids, Resistance To

Aids, Rapid Progression To

Hiv/Aids, Susceptibility To

Hiv-1, Resistance To

Hiv1, Resistance To

Hiv1

Hiv-1 Disease, Delayed Progression Of

Hiv-1 Disease, Rapid Progression Of

Hiv Infection, Resistance To

Hiv Type 1, Susceptibility To

Hiv Type 1

Hiv-1 Infection

Human Immunodeficiency Virus I Infection

Acquired Immunodeficiency Syndrome

Hiv-Infection/Aids

Aicardi-Goutieres Syndrome

Aicardi Goutieres Syndrome

Cree Encephalitis

Encephalopathy With Basal Ganglia Calcification

Aicardi-Goutières Syndrome

Ags

Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid

Pseudotoxoplasmosis Syndrome

Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis

Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis

Aicardi-Goutieres Syndrome 1

Conjunctivitis

Madras Eye

Adenoviral Conjunctivitis

Acute Adenoviral Follicular Conjunctivitis

Inclusion Conjunctivitis Of The Adult

Swimming-Pool Conjunctivitis

Inflammation Of Conjunctiva

Ophthalmia

Acute Conjunctivitis

Eye Catarrh

Catarrhal Ophthalmia

Koch-Weeks Conjunctivitis

Mumps

Parotitis Due To Mumps Virus

Mumps Nos

Epidemic Parotitis

Infectious Parotitis

Avian Influenza

Bird Flu

Influenza In Birds

Avian Flu

Rosacea

Erythematotelangiectatic Rosacea

Papulopustular Rosacea

Phymatous Rosacea

Acne Roscea

Acne, Erythematosa

Granulomatous Rosacea

Ocular Rosacea

Acne Rosacea

Hypertrophic Rosacea

Hand, Foot And Mouth Disease

Vesicular Stomatitis And Exanthem

Aspergillosis

Aspergillosis, Susceptibility To

Infection Due To Aspergillus

Aspergilloma

Aspergillus Nodule

Simple Aspergilloma

Aspergillus

Aspergillus Flavus Infection

Aspergillus Fumigatus Infection

Aspergillus Infection

Infection By Aspergillus Fumigatus

Intracavitary Aspergillus Fungus Ball

Aspergillus Terreus

Subacute Sclerosing Panencephalitis

SSPE

Dawson Encephalitis

Immunosuppressive Measles Encephalitis

Subacute Sclerosing Leukoencephalitis

Panencephalitis, Subacute Sclerosing

Subacute Sclerosing Leukoencephalopathy

Van Bogaert'S Sclerosing Leukoencephalitis

Dawson Disease

Subacute Inclusion Body Encephalitis

Van Bogaert Disease

Van Bogaert Encephalitis

Measles Inclusion Body Encephalitis

Mibe - [Measles Inclusion Body Encephalitis]

Sspe - [Subacute Sclerosing Panencephalitis]

Van Bogaert Leukoencephalitis

Van Bogaert Sclerosing Leukoencephalitis

Dawson Inclusion Body Encephalitis

Van Bogaert Sclerosing Leukoencephalopathy

Bodechtel Guttman Disease

Diffuse Sclerosing Encephalitis

West Nile Fever
Hepatitis C

Chronic Hepatitis C

Hepatitis C Infection

Hepatitis Nona Nonb

Nanbh

Viral Hepatitis C

Hepatitis C Chronic

Hepatitis C, Chronic

Chronic Type C Viral Hepatitis

Chronic Hcv - [Hepatitis C Virus] Infection

Hepatitis C Nos

Hepatitis C Infection Nos

Hepatitis C-Related Cirrhosis

Type C Viral Hepatitis

Hep C Nos

Multisystem Inflammatory Syndrome In Children

Mis-C

Multisystem Inflammatory Disorder In Children And Adolescents

Paediatric Inflammatory Multisystemic Syndrome

Mic

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Alzheimer Disease, Familial, 1

Alzheimer Disease

Alzheimer'S Disease

Presenile And Senile Dementia

AD1

Alzheimer Disease, Susceptibility To

Alzheimer Disease, Late-Onset, Susceptibility To

Alzheimer Disease 1, Familial

AD

Familial Alzheimer Disease

Alzheimer Disease, Late-Onset

Alzheimers Dementia

Alzheimer Dementia

Alzheimer Sclerosis

Alzheimer Syndrome

Alzheimer-Type Dementia

Dat

Primary Senile Degenerative Dementia

Sdat

Alzheimer Disease 1

Autosomal Dominant Alzheimer Disease

Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

Late Onset Alzheimer Disease

Alzheimers Disease

Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

Late-Onset Alzheimers Disease

Alzheimer'S Disease Pathway Kegg

Dementia Due To Alzheimer'S Disease

Alzheimer Disease Type 1

Alzheimers

Herpes Simplex Encephalitis

Hse

Hsv Encephalitis

Hsve

Herpes Simplex Meningo-Encephalitis

Herpes Simplex Neuroinvasion

Herpes Simplex Virus Encephalitis

Herpetic Encephalitis

Herpes Encephalitis

Herpes Simplex Virus 1 Encephalitis

Pulmonary Hypertension

Primary Pulmonary Hypertension

Hypertension Pulmonary

Hypertension, Pulmonary

Idiopathic Pulmonary Hypertension

Idiopathic Pulmonary Arterial Hypertension

Pulmonary Htn - [Hypertension]

Hepatitis B

Chronic Hepatitis B

Hepatitis B Infection

Serum Hepatitis

HBV

Hepatitis B Chronic

Hbv, Susceptibility To

Hepatitis B, Chronic

Chronic Hepatitis B Without Delta Agent

Chronic Hbv - [Hepatitis B Virus] Infection

Hepatitis B Nos

Chronic Type B Viral Hepatitis

Hep B Nos

Poliomyelitis

Infantile Paralysis

Polio

Mouth Disease

Mouth Diseases

Mouth Disorders

Swine Influenza

Influenza Due To Influenza A Virus Subtype H1n1

Salivary Gland Disease

Salivary Gland Disorders

Salivary Gland Diseases

Non-Neoplastic Salivary Gland Disease

Non-Neoplastic Salivary Gland Disorder

Disorder Of Salivary Gland

Lesion Of Salivary Gland Nos

Molluscum Contagiosum

Water Warts

Molluscum Verrucosum

Asthma

Chronic Obstructive Asthma

Asthma, Diminished Response To Antileukotriene Treatment In

Bronchial Hyperreactivity

Asthma, Susceptibility To

Asthma, Bronchial

Asthma, Protection Against

Asthma, Nocturnal, Susceptibility To

Nocturnal Asthma

Asthma-Related Traits

Asthma-Related Traits, Susceptibility To

Asthma, Nocturnal

Chronic Obstructive Asthma With Acute Exacerbation

Chronic Obstructive Asthma With Status Asthmaticus

Exercise Induced Asthma

Exercise-Induced Asthma

Bronchial Asthma

Asthma, Exercise-Induced

Idiosyncratic Asthma

Unspecified Asthma With Acute Exacerbation

Asthma, Unspecified, With Stated Status Asthmaticus

Status Asthmaticus Nos

Acute Severe Asthma

Acute Severe Bronchial Asthma

Status Asthma

Status Post Asthmaticus

Myocarditis

Myocardial Inflammation

Inflammatory Cardiomyopathy

Chikungunya

Chikungunya Fever

Arbovirus A Chikungunya Type

Chik

Chikv Infection

Ck

Chikungunya Virus Infection

Chikungunya Haemorrhagic Fever

Chikungunya Viral Disease

Chikungunya Mosquito-Borne Viral Fever

Chickenpox

Varicella

Varicella Nos

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

Macular Degeneration, Age-Related, 1

Macular Degeneration

Age-Related Macular Degeneration

Macular Degeneration, Age-Related

Age Related Macular Degeneration

Age Related Macular Degeneration 1

ARMD1

Maculopathy, Age-Related, 1

Macular Degeneration, Age-Related, Reduced Risk Of

Age Related Maculopathy 1

Age Related Maculopathies

Age Related Maculopathy

Senile Macular Degeneration

Senile Macular Retinal Degeneration

Macular Degeneration Of Retina

Age-Related Maculopathy

Amd

Armd

Age-Related Maculopathy, Susceptibility To

Maculopathy Age-Related

Macular Degeneration, Age-Related, 1, Susceptibility To

Maculopathy, Age-Related

Macular Degeneration, Age-Related, Type 1

Macular Degeneration, Age-Related, 2

Primary Bacterial Infectious Disease
Rabies

Lyssa

Hydrophobia

St Hubert Disease

Bacterial Sepsis
Influenza

Flu

Influenza With Non-Respiratory Manifestation

Influenza With Other Manifestations

Influenza, Human

Influenza, Susceptibility To

Seasonal Influenza, Virus Identified

Herpes Zoster Ophthalmicus

Hzo

Viral Encephalitis

Epidemic Encephalitis

Encephalitis Viral

Encephalitis, Arbovirus

Arbovirus Encephalitis

Postviral Encephalitis Nos

Equine Encephalitis

Tick-Borne Encephalitis

Viral Encephalitis Transmitted By Tick

Mosquito-Borne Encephalitis

Acute Haemorrhagic Encephalitis

Acute Idiopathic Encephalitis

Chronic Viral Encephalitis

Endemic Encephalitis

Subacute Viral Encephalitis

Viral Haemorrhagic Encephalitis

Viral Nonepidemic Encephalitis

Nonepidemic Encephalitis

Retinal Vasculitis
Bacterial Infectious Disease

Bacterial Infections

Bacterial Infection Nos

Disease Caused By Bacteria

Bacterial Disease Or Disorder

Hepatitis A

Viral Hepatitis A

Viral Hepatitis, Type A

Thalamic Neoplasm

Malignant Neoplasm Of Thalamus

Malignant Tumor Of Thalamus

Tumor Of Thalamus

Hepatitis E
Immunodeficiency 83 Viral Infections

Herpes Simplex Encephalitis, Susceptibility To, 2

IMD83

Immunodeficiency 83, Susceptibility To Viral Infections

Encephalopathy, Acute, Infection-Induced, 2

Encephalopathy, Acute, Infection-Induced, 2, Herpes-Specific

Herpes Simplex Encephalitis 2

Hse2

Iiae2

Infection-Induced Acute Encephalopathy 2

Tlr3-Deficient Herpes Simplex Encephalitis

Encephalitis, Herpes Simplex, Susceptibility To, Type 2

Salmonellosis

Salmonella Infections

Salmonella Infection

Japanese Encephalitis

Japanese B Encephalitis

Je

Encephalitis Japanese

Encephalitis, Japanese

Russian Autumnal Encephalitis

Je - [Japanese Encephalitis]

Japanese Encephalitis Virus Disease

Jbe - [Japanese B Encephalitis}

B Type Encephalitis

Skin Disease

Skin Diseases

Abnormality Of The Skin

Skin Diseases, Genetic

Genodermatosis

Skin And Subcutaneous Tissue Disease

Dermatologic Disorders

Primary Biliary Cholangitis

Primary Biliary Cirrhosis

Biliary Liver Cirrhosis

Chronic Nonsuppurative Destructive Cholangitis

Familial Primary Biliary Cirrhosis

Pbc

Hanot Syndrome

Cholestatic Cirrhosis

Biliary Cirrhosis Primary

Liver Cirrhosis, Biliary

Hanot'S Cirrhosis

Biliary Cirrhosis

Pericholangiolic Biliary Cirrhosis

Tannhauser-Magendantz Syndrome

Hanot-Rossle Syndrome

Hypertrophic Cirrhosis

Todd Cirrhosis

Hanot Cirrhosis

Charcot Cirrhosis

Mahon-Tannhauser Syndrome

Toxic Cirrhosis

Hypertrophic Biliary Cirrhosis

Monolobular Cirrhosis

Unilobar Cirrhosis

Xanthomatous Biliary Cirrhosis

Herpes Zoster

Shingles

Zoster

Herpes Zona

Herpes Zoster Disease

Zona Zoster

Herpes Zoster Of Skin And Mucous Membranes

Zoster Nos

Zoster With Nervous System Involvement

Mucocutaneous Leishmaniasis

American Cutaneous Leishmaniasis

American Mucocutaneous Leishmaniasis

Cutaneous Leishmaniasis, American

Mucocutaneous Leishmaniasis, American

New World Cutaneous Leishmaniasis

Leishmaniasis, Mucocutaneous

Espundia

Leishmania Braziliensis Infection

Melanoma

Malignant Melanoma

Cutaneous Melanoma

Naevocarcinoma

Malignant Melanomas

Nervous System Disease

Abnormality Of The Nervous System

Nervous System Diseases

Nervous System Disorder

Interstitial Lung Disease 2

Idiopathic Pulmonary Fibrosis

Ipf

Fibrocystic Pulmonary Dysplasia

Pulmonary Fibrosis, Idiopathic

Pulmonary Fibrosis, Idiopathic, Susceptibility To

ILD2

Idiopathic Pulmonary Fibrosis, Familial

Fibrosing Alveolitis, Cryptogenic

Uip

Cryptogenic Fibrosing Alveolitis

Fibrosing Alveolitis

Interstitial Pneumonitis, Usual

Familial Idiopathic Pulmonary Fibrosis

Idiopathic Fibrosing Alveolitis, Chronic Form

Usual Interstitial Pneumonia

Fibrosing Alveolitis Cryptogenic

Hamman-Rich Disease

Idiopathic Pulmonary Fibrosis Familial

Interstitial Pneumonitis Usual

Fibrosis Idiopathic Pulmonary

Fibrosis, Pulmonary, Idiopathic

Hamman-Rich Syndrome

Chronic Idiopathic Pulmonary Fibrosis

Acute Interstitial Pneumonia

Interstitial Pulmonary Fibrosis

Ipf - [Idiopathic Pulmonary Fibrosis]

Idiopathic Lung Fibrosis

Fibrosing Lung Disease

Pulmonary Fibrosis Nos

Fibrosing Pneumonitis

Newcastle Disease

Newcastle'S Disease

Pseudo-Fowlpest

Coronavirus Infectious Disease
West Nile Encephalitis

West-Nile Encephalitis

West Nile Fever

West Nile Fever Encephalitis

West Nile Fever With Encephalitis

West-Nile Fever

Encephalitis, West Nile Fever

Diabetes Mellitus

Diabetes

Systemic Lupus Erythematosus

Lupus Nephritis

SLE

Disseminated Lupus Erythematosus

Systemic Lupus Erythematosus, Susceptibility To

Lupus Erythematosus, Systemic

Lupus Nephritis, Susceptibility To

Libman-Sacks Disease

Systemic Lupus Erythematosus Susceptibility To

Sle - Lupus Erythematosus, Systemic

Le Syndrome

Lupus

Lupus Erythematosus Systemic

Lupus Erythematosus, Systemic, Susceptibility To

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus

Systemic Lupus Erythematosus Nos

Sle - [Systemic Lupus Erythematosus]

Tonsillitis

Chronic Tonsillitis

Throat Infection - Tonsillitis

Rubella

German Measles

Three Day Measles

Rubella Nos

X-Linked Immunodeficiency 74

Immunodeficiency 74, Covid-19-Related, X-Linked

Imd74

Respiratory Insufficiency Due To Sars-Cov-2 Viral Infection

Tlr7 Deficiency

X-Linked Immunodeficiency 74,Covid-19-Related

Measles

Rubeola

Morbilli

Measles Nos

Koplik Spots

Viral Infectious Disease

Arbovirus Infections

Viral Disease

Virus Infection

Virus Diseases

Viral Infection

Viral Infections

Virus Infections

Pneumonia

Acute Pneumonia

Pneumonias

Infectious Pneumonia

Pn - [Pneumonia]

Lobar Pneumonia Nos

Multifocal Pneumonia

Orthostatic Pneumonia

Pneumonia Nos

Chronic Pneumonia Nos

Atypical Pneumonia

Passive Pneumonia

Purulent Pneumonia

Interstitial Lobar Pneumonia

Pneumonia, Unspecified

Pneumonia Due To Chlamydia

Pneumonia Due To Chlamydia Pneumoniae

Pneumonia Due To E. Coli

Escherichia Coli Lobar Pneumonia

Pneumonia Due To H. Influenzae

Pneumonia Due To Hemophilus Influenzae

Bronchopneumonia Due To H. Influenzae

Haemophilus Influenzae Lobar Pneumonia

Bronchopneumonia Due To Hemophilus Influenzae

Pseudomonal Pneumonia

Pseudomonas Pneumonia

Pseudomonas Lobar Pneumonia

Staphylococcal Pneumonia

Staphylococcus Pneumonia

Acute Staphylococcal Pneumonia

Staphylococcal Double Pneumonia

Staphylococcal Lobar Pneumonia

Staphylococcal Purulent Pneumonia

Staphylococcal Bronchopneumonia

Pneumococcal Pneumonia

Pneumococcus Pneumonia

Bronchopneumonia Due To S. Pneumoniae

Pneumococcal Lobar Pneumonia

Streptococcal Pneumoniae Pneumonia

Streptococcus Pneumoniae Lobar Pneumonia

Pyemic Pneumococcal Embolism With Pneumonia

Bronchopneumonia Due To Streptococcus Pneumoniae

Pneumonia Due To Streptococcus, Group B

Group B Streptococcal Pneumonia

Adenovirus Pneumonia

Adenoviral Pneumonia

Adenovirus Viral Pneumonia

Pneumonia Respiratory Syncytial Viral

Parainfluenza Viral Pneumonia

Parainfluenzal Pneumonia

Parainfluenza Virus Pneumonia

Human Metapneumovirus Pneumonia

Human Metapneumovirus Infection Resulting In Pneumonia

Pneumocystis Pneumonia

Plasma Cells Pneumonia

Anogenital Venereal Wart

Genital Warts

Condylomata Acuminata

Anogenital Warts

Condyloma Acuminatum

Anogenital Human Papilloma Virus Infectious Disease

Genital Wart Virus Infectious Disease

Venereal Wart

Venereal Warts

Verrucae Anogenitales

Verrucae Genitales

Herpangina

Vesicular Pharyngitis

Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly

Encephalitis

Mumps Encephalitis

Mumps Meningoencephalitis

Herpes Simplex Neuroinvasion

Herpetic Encephalitis

Herpetic Encephalopathy

Herpes Simplex Encephalitis, Myelitis Or Encephalomyelitis

Encephalitis Due To Herpesviridae

Encephalitis Due To Herpesvirus

Herpes Encephalitis

Herpesviral Encephalitis

Herpes Simplex Encephalitis

Hsv - [Herpes Simplex Virus] Encephalitis

Herpes Virus Encephalitis

Simian B Disease

Simian B Disorder

Encephalitis Nec

Idiopathic Encephalitis

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Canis familiaris TLR3 VGNC VGNC:51831
Mus musculus TLR3 MGD MGI:2156367
Macaca mulatta TLR3 VGNC VGNC:78373
Bos taurus TLR3 VGNC VGNC:52833
Rattus norvegicus TLR3 RGD RGD:735171
Felis catus TLR3 VGNC VGNC:66219
Macaca fascicularis TLR3 NCBI NCBI:102138517
Others TLR3 NCBI