2. Gene
  3. MPP7 - MAGUK p55 scaffold protein 7 Gene

MPP7 - MAGUK p55 scaffold protein 7 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 143098 | Gene type: protein coding

About MPP7

Cytogenetic location: 10p12.1 Genomic coordinates (GRCh38): 10:28,050,993-28,335,203 (from NCBI)

This gene has 9 transcripts (splice variants), 225 orthologues and 7 paralogues. Ubiquitous expression in esophagus (RPKM 17.1), skin (RPKM 11.1) and 24 other tissues.

Summary

The protein encoded by this gene is a member of the p55 Stardust family of membrane-associated guanylate kinase (MAGUK) proteins, which function in the establishment of epithelial cell polarity. This family member forms a complex with the polarity protein DLG1 (discs, large homolog 1) and facilitates epithelial cell polarity and tight junction formation. Polymorphisms in this gene are associated with variations in site-specific bone mineral density (BMD). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

MPP7 Products(2)

mRNA Protein Name
NM_001318170.2 NP_001305099.1 MAGUK p55 subfamily member 7
NM_173496.5 NP_775767.2 MAGUK p55 subfamily member 7
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables molecular adaptor activity IDA
IDA: Inferred from direct assay
17237226 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17237226 GOA
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
17332497 GOA
Biological Process GO Annotation Evidence Reference Source
involved in bicellular tight junction assembly IDA
IDA: Inferred from direct assay
17332497 GOA
involved in positive regulation of protein-containing complex assembly IDA
IDA: Inferred from direct assay
17237226 GOA
involved in protein localization to adherens junction IMP
IMP: Inferred from mutant phenotype
17237226 GOA
Cellular Component GO Annotation Evidence Reference Source
part of MPP7-DLG1-LIN7 complex IDA
IDA: Inferred from direct assay
17237226 GOA
located in adherens junction IDA
IDA: Inferred from direct assay
17237226 GOA
located in bicellular tight junction IDA
IDA: Inferred from direct assay
17332497 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MPP7 Protein Structure

L27

L27: L27 domain (13 - 67)

L27

L27: L27 domain (78 - 125)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (141 - 216)

SH3_2

SH3_2: Variant SH3 domain (232 - 295)

Guanylate_kin

Guanylate_kin: Guanylate kinase (368 - 560)

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  • 576 a.a.
Protein Preferred Names Protein Names

MAGUK p55 subfamily member 7

membrane palmitoylated protein 7

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08626 MPP7 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus MPP7 MGD MGI:1922989
Macaca mulatta MPP7 VGNC VGNC:74835
Bos taurus MPP7 VGNC VGNC:31586
Rattus norvegicus MPP7 RGD RGD:1305675
Canis familiaris MPP7 VGNC VGNC:49833
Felis catus MPP7 VGNC VGNC:97517