MPP7 - MAGUK p55 scaffold protein 7 Gene

Homo sapiens

Gene ID: 143098 | Gene type: protein coding

About MPP7

Cytogenetic location: 10p12.1 Genomic coordinates (GRCh38): 10:28,050,993-28,335,203 (from NCBI)

This gene has 9 transcripts (splice variants), 225 orthologues and 7 paralogues. Ubiquitous expression in esophagus (RPKM 17.1), skin (RPKM 11.1) and 24 other tissues.

Summary

The protein encoded by this gene is a member of the p55 Stardust family of membrane-associated guanylate kinase (MAGUK) proteins, which function in the establishment of epithelial cell polarity. This family member forms a complex with the polarity protein DLG1 (discs, large homolog 1) and facilitates epithelial cell polarity and tight junction formation. Polymorphisms in this gene are associated with variations in site-specific bone mineral density (BMD). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

MPP7 Products(2)

mRNA	Protein	Name
NM_001318170.2	NP_001305099.1	MAGUK p55 subfamily member 7
NM_173496.5	NP_775767.2	MAGUK p55 subfamily member 7

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables molecular adaptor activity	IDA IDA: Inferred from direct assay	17237226	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17237226	GOA
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	17332497	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in bicellular tight junction assembly	IDA IDA: Inferred from direct assay	17332497	GOA
involved in positive regulation of protein-containing complex assembly	IDA IDA: Inferred from direct assay	17237226	GOA
involved in protein localization to adherens junction	IMP IMP: Inferred from mutant phenotype	17237226	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of MPP7-DLG1-LIN7 complex	IDA IDA: Inferred from direct assay	17237226	GOA
located in adherens junction	IDA IDA: Inferred from direct assay	17237226	GOA
located in bicellular tight junction	IDA IDA: Inferred from direct assay	17332497	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MPP7 Protein Structure

L27

PDZ

SH3_2

Guanylate_kin

0
100
200
300
400
500
576 a.a.

Protein Preferred Names

Protein Names

MAGUK p55 subfamily member 7

membrane palmitoylated protein 7

MPP7 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MPP7	Q5T2T1	LIN7C	Homo sapiens	Q9NUP9	Validated Y2H	32296183
Intra	MPP7	Q5T2T1	DLGAP4	Homo sapiens	Q9Y2H0-1	Validated Y2H	32296183
Intra	MPP7	Q5T2T1	DLGAP4	Homo sapiens	Q9Y2H0-1	Y2H Prey Pooling	32296183
Intra	MPP7	Q5T2T1	DLGAP4	Homo sapiens	Q9Y2H0-1	Y2H Array	32296183
Intra	MPP7	Q5T2T1	MYSM1	Homo sapiens	Q5VVJ2	Y2H Prey Pooling	32296183
Intra	MPP7	Q5T2T1	MYSM1	Homo sapiens	Q5VVJ2	Validated Y2H	32296183
Intra	MPP7	Q5T2T1	MYSM1	Homo sapiens	Q5VVJ2	Y2H Array	32296183
Intra	MPP7	Q5T2T1	TRIM5	Homo sapiens	Q9C035-3	Validated Y2H	32296183
Intra	MPP7	Q5T2T1	TRIM5	Homo sapiens	Q9C035-3	Y2H Prey Pooling	32296183
Intra	MPP7	Q5T2T1	LIN7A	Homo sapiens	O14910	Y2H Prey Pooling	32296183
Intra	MPP7	Q5T2T1	LIN7A	Homo sapiens	O14910	Y2H Array	32296183
Intra	MPP7	Q5T2T1	LIN7B	Homo sapiens	Q9HAP6	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08626	MPP7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MPP7	MGD	MGI:1922989
Macaca mulatta	MPP7	VGNC	VGNC:74835
Bos taurus	MPP7	VGNC	VGNC:31586
Rattus norvegicus	MPP7	RGD	RGD:1305675
Canis familiaris	MPP7	VGNC	VGNC:49833
Felis catus	MPP7	VGNC	VGNC:97517

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