LIN7B - lin-7 homolog B, crumbs cell polarity complex component Gene

Homo sapiens

Also known as MALS2; VELI2; LIN-7B; MALS-2

Gene ID: 64130 | Gene type: protein coding

About LIN7B

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:49,114,370-49,118,460 (from NCBI)

This gene has 7 transcripts (splice variants), 181 orthologues and 3 paralogues. Ubiquitous expression in brain (RPKM 4.4), testis (RPKM 3.8) and 25 other tissues.

Summary

Enables protein domain specific binding activity. Predicted to be involved in maintenance of epithelial cell apical/basal polarity; neurotransmitter secretion; and protein localization to basolateral plasma membrane. Predicted to be located in plasma membrane. Predicted to be part of MPP7-DLG1-LIN7 complex. Predicted to be active in basolateral plasma membrane; cell-cell junction; and synapse. [provided by Alliance of Genome Resources, Apr 2022]

LIN7B Products(2)

mRNA	Protein	Name
NM_001308419.2	NP_001295348.1	protein lin-7 homolog B isoform 2
NM_022165.3	NP_071448.1	protein lin-7 homolog B isoform 1

LIN7B Protein Structure

L27

PDZ

0
100
207 a.a.

Protein Preferred Names

Protein Names

protein lin-7 homolog B

hLin7B

LIN7B Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	LIN7B	Q9HAP6	CASK	Homo sapiens	O14936-4	Y2H Prey Pooling	32296183
Intra	LIN7B	Q9HAP6	CASK	Homo sapiens	O14936-4	Y2H Array	32296183
Intra	LIN7B	Q9HAP6	MPP2	Homo sapiens	Q14168-4	Y2H Prey Pooling	32296183
Intra	LIN7B	Q9HAP6	MPP2	Homo sapiens	Q14168-4	Y2H Array	32296183
Intra	LIN7B	Q9HAP6	PALS1	Homo sapiens	Q8N3R9	Anti Tag CoIP	33961781
Intra	LIN7B	Q9HAP6	MPP7	Homo sapiens	Q5T2T1	Anti Tag CoIP	33961781
Intra	LIN7B	Q9HAP6	MPP7	Homo sapiens	Q5T2T1	Y2H Prey Pooling	32296183
Intra	LIN7B	Q9HAP6	MPP7	Homo sapiens	Q5T2T1	Y2H Array	32296183
Intra	LIN7B	Q9HAP6	PALS2	Homo sapiens	Q9NZW5	Y2H Prey Pooling	32296183
Intra	LIN7B	Q9HAP6	PALS2	Homo sapiens	Q9NZW5	Validated Y2H	32296183
Intra	LIN7B	Q9HAP6	PALS2	Homo sapiens	Q9NZW5	Y2H Array	32296183
Intra	LIN7B	Q9HAP6	PALS2	Homo sapiens	Q9NZW5	Anti Tag CoIP	33961781
Intra	LIN7B	Q9HAP6	MPP3	Homo sapiens	Q13368	Y2H Prey Pooling	32296183
Intra	LIN7B	Q9HAP6	MPP3	Homo sapiens	Q13368	Y2H Array	32296183
Intra	LIN7B	Q9HAP6	MPP3	Homo sapiens	Q13368	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder	ADHD
Attention Deficit Disorder	Attention Deficit-Hyperactivity Disorder, Susceptibility To
Attention Deficit Disorder With Hyperactivity	Hyperkinetic Disorder
Hyperactivity Of Childhood	Attention-Deficit/Hyperactivity Disorder
Add	Addh
Attention Deficit	Attention Deficit Disorder Of Childhood With Hyperactivity
Attention Deficit Disorder With Hyperactivity Syndrome	Hyperkinetic Syndrome
Attention-Deficit Hyperactivity Disorder	Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type
Disturbance Of Activity And Attention	Disorder Of Activity And Attention
Adhd - [Attention Deficit Hyperactivity Disorder]	Hyperkinetic Disorders
Disorder Of Activity And Attention With Hyperkinesia	Attention Deficit Syndrome With Hyperactivity

Huntington Disease

Huntington'S Disease	Huntington Chorea
Huntington'S Chorea	HD
Huntington Chronic Progressive Hereditary Chorea	Juvenile Huntington Disease
Chronic Progressive Chorea	Chronic Progressive Hereditary Chorea
Hc - [Huntington Chorea]	Hereditary Chorea
Progressive Hereditary Chorea

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07677	LIN7B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	LIN7B	VGNC	VGNC:53735
Macaca mulatta	LIN7B	VGNC	VGNC:74069
Mus musculus	LIN7B	MGD	MGI:1330858
Rattus norvegicus	LIN7B	RGD	RGD:620730
Bos taurus	LIN7B	VGNC	VGNC:30896
Felis catus	LIN7B	VGNC	VGNC:63234

Name
Email *

	Sorry, but the email address you supplied was invalid.