LIN7C - lin-7 homolog C, crumbs cell polarity complex component Gene

Homo sapiens

Also known as MALS3; VELI3; LIN-7C; MALS-3; LIN-7-C

Gene ID: 55327 | Gene type: protein coding

About LIN7C

Cytogenetic location: 11p14.1 Genomic coordinates (GRCh38): 11:27,494,418-27,506,769 (from NCBI)

This gene has 2 transcripts (splice variants), 213 orthologues and 3 paralogues. Ubiquitous expression in thyroid (RPKM 9.8), liver (RPKM 7.0) and 25 other tissues.

Summary

Enables L27 domain binding activity and cytoskeletal protein binding activity. Involved in morphogenesis of an epithelial sheet. Located in cell-cell junction; cytoplasm; and plasma membrane. Part of MPP7-DLG1-LIN7 complex. [provided by Alliance of Genome Resources, Apr 2022]

LIN7C Products(1)

mRNA	Protein	Name
NM_018362.4	NP_060832.1	protein lin-7 homolog C

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables L27 domain binding	IDA IDA: Inferred from direct assay	20702775	GOA
enables cytoskeletal protein binding	IPI IPI: Inferred from physical interaction	17987659	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21849460	GOA
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	17237226	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in morphogenesis of an epithelial sheet	IMP IMP: Inferred from mutant phenotype	23201090	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of MPP7-DLG1-LIN7 complex	IDA IDA: Inferred from direct assay	20702775	GOA
located in cell-cell junction	IDA IDA: Inferred from direct assay	23201090	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	23201090	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	21849460	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LIN7C Protein Structure

L27

PDZ

0
100
197 a.a.

Protein Preferred Names

Protein Names

protein lin-7 homolog C

LIN-7 protein 3

Related Diseases

Diseases

Alias

Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder	ADHD
Attention Deficit Disorder	Attention Deficit-Hyperactivity Disorder, Susceptibility To
Attention Deficit Disorder With Hyperactivity	Hyperkinetic Disorder
Hyperactivity Of Childhood	Attention-Deficit/Hyperactivity Disorder
Add	Addh
Attention Deficit	Attention Deficit Disorder Of Childhood With Hyperactivity
Attention Deficit Disorder With Hyperactivity Syndrome	Hyperkinetic Syndrome
Attention-Deficit Hyperactivity Disorder	Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type
Disturbance Of Activity And Attention	Disorder Of Activity And Attention
Adhd - [Attention Deficit Hyperactivity Disorder]	Hyperkinetic Disorders
Disorder Of Activity And Attention With Hyperkinesia	Attention Deficit Syndrome With Hyperactivity

Wilms Tumor, Aniridia, Genitourinary Anomalies, And Mental Retardation Syndrome

Wagr Syndrome	11p Partial Monosomy Syndrome
Chromosome 11p13 Deletion Syndrome	Wilms Tumor, Aniridia, Genitourinary Anomalies And Mental Retardation Syndrome
11p Deletion Syndrome	Chromosome 11p Deletion Syndrome
Wagr Complex	Wilms Tumor-Aniridia-Genitourinary Anomalies-Intellectual Disability Syndrome
Deletion 11p13	WAGR
Wilms Tumor-Aniridia-Genitourinary Anomalies-Mental Retardation Syndrome	Chromosome 11p Deletion
11p Deletion	11p Monosomy
Deletion 11p	Monosomy 11p
Partial Monosomy 11p	Agr Triad
Wilms Tumor-Aniridia-Gonadoblastoma-Mental Retardation Syndrome	Wilms Tumor, Aniridia, Genitourinary Anomalies, Mental Retardation Syndrome
Wagr Contiguous Gene Syndrome	Wilms Tumor-Aniridia-Genital Anomalies-Retardation Syndrome
Wilms Tumor-Aniridia-Genitourinary Anomalies-Mr Syndrome	Del(11)(P13)
Monosomy 11p13	Chromosome 11, Deletion 11p

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07678	LIN7C Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	LIN7C	VGNC	VGNC:82034
Macaca mulatta	LIN7C	VGNC	VGNC:74070
Mus musculus	LIN7C	MGD	MGI:1330839
Rattus norvegicus	LIN7C	RGD	RGD:621164
Bos taurus	LIN7C	VGNC	VGNC:30897

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